YNR065C_p

Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR065C / YNR065C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.50|P-value:5.65E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:2.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:5.44|P-value:5.99E-8 ID:SGTC_101|Compound:0490-5701|FD-Score:3.81|P-value:9.45E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.41|P-value:7.21E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.25|P-value:1.68E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:4.00|P-value:4.61E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.51|P-value:2.92E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.18|P-value:8.94E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.00|P-value:5.74E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.59|P-value:3.85E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.67|P-value:2.60E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.23|P-value:7.45E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.62|P-value:3.33E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.49|P-value:5.45E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:9.86E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.46|P-value:3.47E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.25|P-value:1.69E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-4.17|P-value:4.48E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.99|P-value:4.83E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.85|P-value:1.15E-6 ID:SGTC_1967|Compound:st070177|FD-Score:-4.82|P-value:2.91E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.97|P-value:5.10E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.26|P-value:6.81E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.55|P-value:2.49E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.95|P-value:5.50E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.51|P-value:5.16E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.29|P-value:6.20E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.00|P-value:8.92E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.51|P-value:5.10E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.19|P-value:8.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.80|P-value:1.87E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.36|P-value:9.11E-8 ID:SGTC_2915|Compound:7971052|FD-Score:-4.52|P-value:1.05E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.28|P-value:1.44E-5 ID:SGTC_2979|Compound:9012552|FD-Score:3.91|P-value:6.56E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.86E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.64|P-value:3.25E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.41|P-value:4.11E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.44|P-value:7.21E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.24|P-value:7.24E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.50|P-value:5.65E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:2.92E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:5.44|P-value:5.99E-8 ID:SGTC_101|Compound:0490-5701|FD-Score:3.81|P-value:9.45E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.41|P-value:7.21E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.25|P-value:1.68E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:4.00|P-value:4.61E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.51|P-value:2.92E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.86|P-value:7.85E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.18|P-value:8.94E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.00|P-value:5.74E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.59|P-value:3.85E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.67|P-value:2.60E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.23|P-value:7.45E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.62|P-value:3.33E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.49|P-value:5.45E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:9.86E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.46|P-value:3.47E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.25|P-value:1.69E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-4.17|P-value:4.48E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.99|P-value:4.83E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.85|P-value:1.15E-6 ID:SGTC_1967|Compound:st070177|FD-Score:-4.82|P-value:2.91E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.97|P-value:5.10E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.26|P-value:6.81E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.55|P-value:2.49E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.95|P-value:5.50E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.51|P-value:5.16E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.29|P-value:6.20E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.00|P-value:8.92E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.51|P-value:5.10E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.19|P-value:8.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.80|P-value:1.87E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.36|P-value:9.11E-8 ID:SGTC_2915|Compound:7971052|FD-Score:-4.52|P-value:1.05E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.28|P-value:1.44E-5 ID:SGTC_2979|Compound:9012552|FD-Score:3.91|P-value:6.56E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.86E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.64|P-value:3.25E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.41|P-value:4.11E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.44|P-value:7.21E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.24|P-value:7.24E-4

Top fitness defect scores for YNR065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_93 0109-0045 5.44 59.2 µM 5.99E-8 DNA damage response 15 2.61E-8
2 SGTC_2912 7964298 5.36 10.9 µM 9.11E-8 cell wall 58 4.09E-8
3 SGTC_1003 4049-0218 5.00 100.0 µM 5.74E-7 7 2.94E-7
4 SGTC_1767 st044992 4.85 70.3 µM 1.15E-6 8 6.19E-7
5 SGTC_1370 2001-0092 4.67 44.6 µM 2.60E-6 15 1.48E-6
6 SGTC_1581 himbacine 4.62 57.9 µM 3.33E-6 Golgi 37 1.93E-6
7 SGTC_1255 0566-0045 4.59 221.0 µM 3.85E-6 excess fatty acid 18 2.25E-6
8 SGTC_35 0133-0054 4.50 64.1 µM 5.65E-6 18 3.39E-6
9 SGTC_3301 9125354 4.44 19.8 µM 7.21E-6 9 4.40E-6
10 SGTC_2974 9094440 4.28 9.7 µM 1.44E-5 ergosterol biosynthesis 38 9.23E-6
11 SGTC_470 aa-861 4.25 153.0 µM 1.68E-5 sphingolipid biosynthesis & PDR1 43 1.09E-5
12 SGTC_1724 st037281 4.25 8.3 µM 1.69E-5 35 1.09E-5
13 SGTC_723 4182-0001 4.00 115.0 µM 4.61E-5 26 3.18E-5
14 SGTC_1728 st035614 3.99 33.8 µM 4.83E-5 46 3.34E-5
15 SGTC_2012 4023501 3.97 200.0 µM 5.10E-5 30 3.54E-5
16 SGTC_2059 5238311 3.95 157.0 µM 5.50E-5 28 3.84E-5
17 SGTC_2979 9012552 3.91 45.5 µM 6.56E-5 9 4.63E-5
18 SGTC_778 3456-2434 3.86 196.0 µM 7.85E-5 mitochondrial response to ROS 80 5.61E-5
19 SGTC_2706 st078239 3.83 82.5 µM 9.07E-5 14 6.54E-5
20 SGTC_101 0490-5701 3.81 117.5 µM 9.45E-5 14 6.83E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.53E-9 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.097 1.57E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.096 2.83E-8 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.094 4.29E-8 YGL127C SOH1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
0.091 1.23E-7 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.090 1.61E-7 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.088 3.43E-7 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.085 9.49E-7 YLR296W_d YLR296W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.25E-6 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.082 2.01E-6 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.082 2.09E-6 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.081 2.93E-6 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.080 3.20E-6 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.077 8.64E-6 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.074 1.67E-5 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR