YNR066C_p

Putative membrane-localized protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR066C / YNR066C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.24|P-value:3.58E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.12|P-value:5.57E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.29|P-value:9.67E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.28|P-value:9.95E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.17|P-value:8.34E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:7.05|P-value:2.75E-11 ID:SGTC_738|Compound:1315-0003|FD-Score:4.59|P-value:8.70E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.75|P-value:4.37E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:5.39|P-value:2.40E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.82|P-value:1.69E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.01|P-value:8.38E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:5.88|P-value:2.06E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.92|P-value:1.17E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.70|P-value:4.33E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.76|P-value:2.03E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.37|P-value:2.11E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.58|P-value:3.83E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.59|P-value:3.74E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.31|P-value:9.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.27|P-value:5.76E-5 ID:SGTC_2005|Compound:4024620|FD-Score:4.58|P-value:9.10E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.81|P-value:3.45E-6 ID:SGTC_2028|Compound:5153890|FD-Score:4.95|P-value:1.85E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.58|P-value:3.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.74|P-value:1.75E-10 ID:SGTC_2293|Compound:7624732|FD-Score:3.89|P-value:1.32E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.47|P-value:8.99E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.35|P-value:8.11E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.34|P-value:8.30E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.80|P-value:3.07E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.44|P-value:5.96E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.74|P-value:4.19E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-6.89|P-value:1.81E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.48|P-value:1.34E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.61|P-value:3.71E-10 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.72|P-value:2.36E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.81|P-value:1.71E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.11|P-value:5.81E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_3036|Compound:9090181|FD-Score:4.99|P-value:1.58E-6 ID:SGTC_3049|Compound:9092223|FD-Score:-4.20|P-value:7.45E-5 ID:SGTC_3058|Compound:9093861|FD-Score:5.86|P-value:2.29E-8 ID:SGTC_3072|Compound:9116419|FD-Score:-3.56|P-value:6.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.52|P-value:4.66E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.77|P-value:4.11E-6 ID:SGTC_3205|Compound:9113483|FD-Score:3.45|P-value:5.90E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.72|P-value:5.10E-6 ID:SGTC_3255|Compound:9139072|FD-Score:4.16|P-value:4.88E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.31|P-value:9.13E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.24|P-value:3.58E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.12|P-value:5.57E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.29|P-value:9.67E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.28|P-value:9.95E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.17|P-value:8.34E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:7.05|P-value:2.75E-11 ID:SGTC_738|Compound:1315-0003|FD-Score:4.59|P-value:8.70E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.75|P-value:4.37E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:5.39|P-value:2.40E-7 ID:SGTC_877|Compound:0771-0151|FD-Score:3.82|P-value:1.69E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.01|P-value:8.38E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:5.88|P-value:2.06E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.92|P-value:1.17E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.70|P-value:4.33E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.76|P-value:2.03E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.48|P-value:5.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.37|P-value:2.11E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.58|P-value:3.83E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.59|P-value:3.74E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.31|P-value:9.18E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.27|P-value:5.76E-5 ID:SGTC_2005|Compound:4024620|FD-Score:4.58|P-value:9.10E-6 ID:SGTC_2024|Compound:5144227|FD-Score:4.81|P-value:3.45E-6 ID:SGTC_2028|Compound:5153890|FD-Score:4.95|P-value:1.85E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.58|P-value:3.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.74|P-value:1.75E-10 ID:SGTC_2293|Compound:7624732|FD-Score:3.89|P-value:1.32E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.47|P-value:8.99E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.35|P-value:8.11E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.34|P-value:8.30E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.80|P-value:3.07E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.44|P-value:5.96E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.74|P-value:4.19E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-6.89|P-value:1.81E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.48|P-value:1.34E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.61|P-value:3.71E-10 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.72|P-value:2.36E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.81|P-value:1.71E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.11|P-value:5.81E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_3036|Compound:9090181|FD-Score:4.99|P-value:1.58E-6 ID:SGTC_3049|Compound:9092223|FD-Score:-4.20|P-value:7.45E-5 ID:SGTC_3058|Compound:9093861|FD-Score:5.86|P-value:2.29E-8 ID:SGTC_3072|Compound:9116419|FD-Score:-3.56|P-value:6.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.52|P-value:4.66E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.77|P-value:4.11E-6 ID:SGTC_3205|Compound:9113483|FD-Score:3.45|P-value:5.90E-4 ID:SGTC_3236|Compound:9132701|FD-Score:4.72|P-value:5.10E-6 ID:SGTC_3255|Compound:9139072|FD-Score:4.16|P-value:4.88E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.31|P-value:9.13E-4

Top fitness defect scores for YNR066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_700 3453-2283 7.05 142.0 µM 2.75E-11 amide catabolism 3 9.20E-13
2 SGTC_2165 5727197 6.74 32.1 µM 1.75E-10 5 7.94E-12
3 SGTC_2628 lathosterol 6.61 100.0 µM 3.71E-10 4 1.89E-11
4 SGTC_969 1313-0238 5.88 134.0 µM 2.06E-8 mitochondrial processes 6 2.02E-9
5 SGTC_3058 9093861 5.86 49.5 µM 2.29E-8 6 2.28E-9
6 SGTC_2562 3',7'-dimethoxyflavone 5.74 64.9 µM 4.19E-8 5 4.60E-9
7 SGTC_789 1309-1135 5.39 70.6 µM 2.40E-7 ERG2 8 3.48E-8
8 SGTC_3036 9090181 4.99 49.5 µM 1.58E-6 3 3.09E-7
9 SGTC_2028 5153890 4.95 36.4 µM 1.85E-6 cell wall signaling 18 3.69E-7
10 SGTC_2024 5144227 4.81 134.0 µM 3.45E-6 18 7.61E-7
11 SGTC_3201 9113999 4.77 49.5 µM 4.11E-6 16 9.32E-7
12 SGTC_740 k014-0057 4.75 261.0 µM 4.37E-6 10 1.00E-6
13 SGTC_3236 9132701 4.72 49.5 µM 5.10E-6 TSC3-RPN4 11 1.20E-6
14 SGTC_738 1315-0003 4.59 72.4 µM 8.70E-6 13 2.21E-6
15 SGTC_2005 4024620 4.58 188.0 µM 9.10E-6 12 2.33E-6
16 SGTC_2627 acetyl isogambogic acid 4.48 100.0 µM 1.34E-5 TSC3-RPN4 31 3.66E-6
17 SGTC_1648 st011736 4.37 69.8 µM 2.11E-5 PDR1 7 6.16E-6
18 SGTC_58 0957-0393 4.24 9.0 µM 3.58E-5 cell wall 348 1.13E-5
19 SGTC_3255 9139072 4.16 49.5 µM 4.88E-5 14 1.62E-5
20 SGTC_167 3672-0051 4.12 66.2 µM 5.57E-5 39 1.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.73E-10 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.100 6.49E-9 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.092 8.90E-8 YLR194C YLR194C hom Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
0.090 1.59E-7 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
0.088 3.28E-7 YKL159C RCN1 hom Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
0.083 1.62E-6 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.081 2.34E-6 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.079 4.43E-6 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.076 9.44E-6 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.076 1.10E-5 YIL076W SEC28 hom Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress
0.075 1.51E-5 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.074 1.77E-5 YLR375W STP3 hom Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
0.072 3.13E-5 YDR538W PAD1 hom Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
0.072 3.23E-5 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.071 3.73E-5 YCR099C_p YCR099C_p hom Putative protein of unknown function