YNR068C_p

Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR068C / YNR068C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.36|P-value:3.32E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.03|P-value:1.94E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.77|P-value:5.96E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.03|P-value:9.77E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.08|P-value:8.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.14|P-value:6.64E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:4.48|P-value:2.37E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:3.17|P-value:6.07E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.01|P-value:2.13E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.55|P-value:1.56E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.10|P-value:8.36E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.33|P-value:3.34E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:6.33|P-value:5.48E-11 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.03|P-value:9.68E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.29|P-value:4.30E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.77|P-value:6.03E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.08|P-value:8.36E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.86|P-value:4.11E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.08|P-value:8.33E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.41|P-value:2.76E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.67|P-value:9.01E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.99|P-value:2.32E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.14|P-value:7.41E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.02|P-value:2.25E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.47|P-value:2.47E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.32|P-value:5.16E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.00|P-value:4.84E-13 ID:SGTC_3144|Compound:9087057|FD-Score:3.77|P-value:5.92E-5 ID:SGTC_3170|Compound:9103054|FD-Score:4.77|P-value:5.63E-7 ID:SGTC_3185|Compound:9108267|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.89|P-value:3.60E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.41|P-value:2.76E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.36|P-value:3.32E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.03|P-value:1.94E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.29|P-value:3.82E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.41|P-value:2.46E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.77|P-value:5.96E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.03|P-value:9.77E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.08|P-value:8.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.14|P-value:6.64E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:4.48|P-value:2.37E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:3.17|P-value:6.07E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.01|P-value:2.13E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.55|P-value:1.56E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.10|P-value:8.36E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.33|P-value:3.34E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:6.33|P-value:5.48E-11 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.03|P-value:9.68E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.29|P-value:4.30E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.77|P-value:6.03E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.08|P-value:8.36E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.86|P-value:4.11E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.08|P-value:8.33E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.41|P-value:2.76E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.67|P-value:9.01E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.99|P-value:2.32E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.14|P-value:7.41E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.23|P-value:4.75E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.22|P-value:4.93E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.02|P-value:2.25E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:4.47|P-value:2.47E-6 ID:SGTC_2944|Compound:9067346|FD-Score:4.32|P-value:5.16E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.19|P-value:5.58E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.00|P-value:4.84E-13 ID:SGTC_3144|Compound:9087057|FD-Score:3.77|P-value:5.92E-5 ID:SGTC_3170|Compound:9103054|FD-Score:4.77|P-value:5.63E-7 ID:SGTC_3185|Compound:9108267|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.89|P-value:3.60E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.41|P-value:2.76E-4

Top fitness defect scores for YNR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2993 9054257 7.00 71.4 µM 4.84E-13 fatty acid desaturase (OLE1) 14 1.30E-12
2 SGTC_1027 k015-0025 6.33 8.7 µM 5.48E-11 2 1.24E-10
3 SGTC_3170 9103054 4.77 49.5 µM 5.63E-7 60S ribosome export 5 9.18E-7
4 SGTC_810 3825-7150 4.48 143.0 µM 2.37E-6 60S ribosome export 4 3.68E-6
5 SGTC_2739 tacrine 4.47 100.9 µM 2.47E-6 heme requiring 11 3.82E-6
6 SGTC_2944 9067346 4.32 25.6 µM 5.16E-6 15 7.78E-6
7 SGTC_66 0109-0187 4.03 42.4 µM 1.94E-5 40 2.79E-5
8 SGTC_892 0929-0076 4.01 29.0 µM 2.13E-5 TRP & mitochondrial translation 36 3.05E-5
9 SGTC_1850 st056238 3.99 17.0 µM 2.32E-5 RPP1 & pyrimidine depletion 20 3.31E-5
10 SGTC_3194 9111903 3.89 49.5 µM 3.60E-5 24 5.07E-5
11 SGTC_1446 4239-0190 3.86 62.0 µM 4.11E-5 42 5.75E-5
12 SGTC_3144 9087057 3.77 49.5 µM 5.92E-5 16 8.17E-5
13 SGTC_288 1315-0019 3.77 35.1 µM 5.96E-5 RSC & ERG11 27 8.22E-5
14 SGTC_1269 0831-0796 3.77 3.0 µM 6.03E-5 60S ribosome export 16 8.32E-5
15 SGTC_1674 st016616 3.67 23.6 µM 9.01E-5 36 1.23E-4
16 SGTC_493 zm226600 3.56 134.0 µM 1.38E-4 mitochondrial processes 23 1.84E-4
17 SGTC_21 0849-0113 3.46 23.0 µM 2.01E-4 44 2.66E-4
18 SGTC_270 tamoxifen 3.41 5.5 µM 2.46E-4 NEO1 56 3.22E-4
19 SGTC_3185 9108267 3.40 49.5 µM 2.57E-4 60S ribosome export 37 3.36E-4
20 SGTC_1063 disulfiram 3.37 1.8 µM 2.83E-4 46 3.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 8.65E-12 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.107 5.72E-10 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.093 6.13E-8 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.093 7.74E-8 YBR297W MAL33 hom MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
0.091 1.44E-7 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.090 1.66E-7 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.085 8.76E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.084 9.53E-7 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function
0.084 1.25E-6 YDR070C FMP16 hom Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.083 1.51E-6 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.082 1.85E-6 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.082 1.96E-6 YHR191C CTF8 hom Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
0.081 2.39E-6 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.081 2.63E-6 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.076 1.14E-5 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex