YNR069C / BSC5

Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR069C / BSC5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-3.68|P-value:2.57E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:7.35|P-value:1.52E-12 ID:SGTC_62|Compound:0180-0423|FD-Score:3.99|P-value:7.67E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.69|P-value:4.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.07|P-value:5.58E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.63|P-value:3.08E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.27|P-value:2.54E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.29|P-value:8.71E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.83|P-value:1.40E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.34|P-value:8.16E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.19|P-value:3.43E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.56|P-value:3.54E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.85|P-value:1.38E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.61|P-value:3.01E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.86|P-value:1.35E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.31|P-value:8.27E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.48|P-value:5.06E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.98|P-value:7.81E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.35|P-value:7.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.36|P-value:1.71E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.38|P-value:1.62E-7 ID:SGTC_2213|Compound:7173844|FD-Score:4.40|P-value:1.48E-5 ID:SGTC_2333|Compound:9017922|FD-Score:6.48|P-value:3.99E-10 ID:SGTC_2336|Compound:9001819|FD-Score:4.27|P-value:2.50E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.73|P-value:3.57E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.37|P-value:6.78E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.37|P-value:6.74E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.63|P-value:3.03E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.71|P-value:3.82E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.32|P-value:2.07E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.51|P-value:9.39E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-4.13|P-value:4.76E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.71|P-value:2.11E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.93|P-value:9.62E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.77|P-value:2.92E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.47|P-value:5.32E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.38|P-value:7.22E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.70|P-value:3.99E-6 ID:SGTC_2896|Compound:9052656|FD-Score:7.83|P-value:5.42E-14 ID:SGTC_2897|Compound:9048598|FD-Score:7.16|P-value:5.55E-12 ID:SGTC_2989|Compound:9073649|FD-Score:4.47|P-value:1.11E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.72|P-value:4.08E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.00|P-value:7.38E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-4.47|P-value:1.22E-5 ID:SGTC_3306|Compound:9127676|FD-Score:5.02|P-value:9.60E-7 ID:SGTC_3341|Compound:9147222|FD-Score:4.34|P-value:1.88E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.68|P-value:2.57E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:7.35|P-value:1.52E-12 ID:SGTC_62|Compound:0180-0423|FD-Score:3.99|P-value:7.67E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.69|P-value:4.18E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.07|P-value:5.58E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.63|P-value:3.08E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.27|P-value:2.54E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.29|P-value:8.71E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.83|P-value:1.40E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.34|P-value:8.16E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.19|P-value:3.43E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.56|P-value:3.54E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.85|P-value:1.38E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.61|P-value:3.01E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.86|P-value:1.35E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.31|P-value:8.27E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.48|P-value:5.06E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.98|P-value:7.81E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.35|P-value:7.33E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.36|P-value:1.71E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.38|P-value:1.62E-7 ID:SGTC_2213|Compound:7173844|FD-Score:4.40|P-value:1.48E-5 ID:SGTC_2333|Compound:9017922|FD-Score:6.48|P-value:3.99E-10 ID:SGTC_2336|Compound:9001819|FD-Score:4.27|P-value:2.50E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.73|P-value:3.57E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.37|P-value:6.78E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.37|P-value:6.74E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.63|P-value:3.03E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.71|P-value:3.82E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:4.32|P-value:2.07E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.51|P-value:9.39E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.71|P-value:2.13E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.29|P-value:9.47E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-4.13|P-value:4.76E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.71|P-value:2.11E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.93|P-value:9.62E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.77|P-value:2.92E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.47|P-value:5.32E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.38|P-value:7.22E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.70|P-value:3.99E-6 ID:SGTC_2896|Compound:9052656|FD-Score:7.83|P-value:5.42E-14 ID:SGTC_2897|Compound:9048598|FD-Score:7.16|P-value:5.55E-12 ID:SGTC_2989|Compound:9073649|FD-Score:4.47|P-value:1.11E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.72|P-value:4.08E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.00|P-value:7.38E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-4.47|P-value:1.22E-5 ID:SGTC_3306|Compound:9127676|FD-Score:5.02|P-value:9.60E-7 ID:SGTC_3341|Compound:9147222|FD-Score:4.34|P-value:1.88E-5

Top fitness defect scores for YNR069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2896 9052656 7.83 71.4 µM 5.42E-14 endomembrane recycling 21 2.37E-15
2 SGTC_61 0978-8327 7.35 98.6 µM 1.52E-12 ergosterol biosynthesis 2 9.66E-14
3 SGTC_2897 9048598 7.16 13.0 µM 5.55E-12 2 4.05E-13
4 SGTC_2333 9017922 6.48 200.0 µM 3.99E-10 4 4.68E-11
5 SGTC_2122 5258151 5.38 111.7 µM 1.62E-7 10 3.67E-8
6 SGTC_3306 9127676 5.02 59.8 µM 9.60E-7 9 2.64E-7
7 SGTC_2805 7950783 4.77 58.4 µM 2.92E-6 10 9.03E-7
8 SGTC_2358 9037157 4.73 4.0 µM 3.57E-6 12 1.13E-6
9 SGTC_2535 4',4'-dimethoxydalbergione 4.71 51.2 µM 3.82E-6 DNA damage response 7 1.22E-6
10 SGTC_2841 9004761 4.70 39.0 µM 3.99E-6 amide catabolism 11 1.28E-6
11 SGTC_63 0099-0242 4.69 26.7 µM 4.18E-6 mitochondrial stress 67 1.35E-6
12 SGTC_2610 ononetin 4.51 44.2 µM 9.39E-6 26 3.30E-6
13 SGTC_2989 9073649 4.47 71.4 µM 1.11E-5 22 3.98E-6
14 SGTC_2213 7173844 4.40 200.0 µM 1.48E-5 8 5.47E-6
15 SGTC_2083 5306046 4.36 65.9 µM 1.71E-5 16 6.39E-6
16 SGTC_3341 9147222 4.34 25.9 µM 1.88E-5 RNA processing & uracil transport 8 7.11E-6
17 SGTC_2607 solasodine 4.32 47.4 µM 2.07E-5 48 7.91E-6
18 SGTC_2336 9001819 4.27 198.7 µM 2.50E-5 heme biosynthesis & mitochondrial translocase 42 9.74E-6
19 SGTC_117 lucigenin 4.27 22.1 µM 2.54E-5 redox potentiating 72 9.93E-6
20 SGTC_411 enrofloxacin 4.19 100.0 µM 3.43E-5 DNA damage response 9 1.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.23E-8 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.094 4.66E-8 YOL070C NBA1 hom Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.094 4.80E-8 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.091 1.48E-7 YNL175C NOP13 hom Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
0.087 5.29E-7 YLR456W_p YLR456W_p hom Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication
0.086 5.67E-7 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.085 9.11E-7 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.084 1.26E-6 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.083 1.60E-6 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.080 3.47E-6 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.079 4.81E-6 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.078 5.48E-6 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
0.077 7.05E-6 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.077 7.48E-6 YJL186W MNN5 hom Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.077 7.73E-6 YMR197C VTI1 het Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways