YNR070W_p / PDR18

Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR070W / PDR18

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:-3.29|P-value:3.90E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.69|P-value:8.19E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.08|P-value:1.45E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.17|P-value:6.01E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.37|P-value:2.01E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.26|P-value:6.27E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:3.44|P-value:1.54E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.99|P-value:8.40E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.32|P-value:2.48E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.25|P-value:2.12E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.59|P-value:8.34E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.80|P-value:3.51E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:6.51|P-value:5.97E-12 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.18|P-value:4.22E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.27|P-value:4.19E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.46|P-value:1.42E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.44|P-value:1.56E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.62|P-value:7.02E-7 ID:SGTC_1755|Compound:st041960|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.40|P-value:2.07E-6 ID:SGTC_1837|Compound:st055472|FD-Score:4.63|P-value:6.59E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.69|P-value:5.57E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.29|P-value:2.83E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:1.88E-5 ID:SGTC_2198|Compound:6589944|FD-Score:4.72|P-value:4.14E-7 ID:SGTC_2262|Compound:9014885|FD-Score:3.66|P-value:6.28E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.49|P-value:1.29E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.08|P-value:6.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.32|P-value:3.49E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.88|P-value:2.47E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.16|P-value:6.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.07|P-value:8.58E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.66|P-value:8.93E-5 ID:SGTC_3151|Compound:9099821|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.09E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.44|P-value:2.22E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.29|P-value:3.90E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.69|P-value:8.19E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.08|P-value:1.45E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.17|P-value:6.01E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.37|P-value:2.01E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.26|P-value:6.27E-11 ID:SGTC_792|Compound:4534-1957|FD-Score:3.44|P-value:1.54E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.45|P-value:1.49E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.99|P-value:8.40E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.32|P-value:2.48E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.25|P-value:2.12E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.59|P-value:8.34E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.80|P-value:3.51E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:6.51|P-value:5.97E-12 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.18|P-value:4.22E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.27|P-value:4.19E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.46|P-value:1.42E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.44|P-value:1.56E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.62|P-value:7.02E-7 ID:SGTC_1755|Compound:st041960|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.40|P-value:2.07E-6 ID:SGTC_1837|Compound:st055472|FD-Score:4.63|P-value:6.59E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.69|P-value:5.57E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.29|P-value:2.83E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:1.88E-5 ID:SGTC_2198|Compound:6589944|FD-Score:4.72|P-value:4.14E-7 ID:SGTC_2262|Compound:9014885|FD-Score:3.66|P-value:6.28E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.49|P-value:1.29E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.08|P-value:6.12E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.32|P-value:3.49E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.88|P-value:2.47E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.16|P-value:6.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.07|P-value:8.58E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.66|P-value:8.93E-5 ID:SGTC_3151|Compound:9099821|FD-Score:2.95|P-value:9.57E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.09E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.44|P-value:2.22E-4

Top fitness defect scores for YNR070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1360 1598-0022 6.51 39.8 µM 5.97E-12 ERG2 6 3.86E-11
2 SGTC_1248 0469-0687 5.25 58.6 µM 2.12E-8 7 7.61E-8
3 SGTC_2198 6589944 4.72 200.0 µM 4.14E-7 11 1.20E-6
4 SGTC_1837 st055472 4.63 66.5 µM 6.59E-7 12 1.85E-6
5 SGTC_1500 4488-1866 4.62 171.0 µM 7.02E-7 RPP1 & pyrimidine depletion 7 1.96E-6
6 SGTC_1834 st055981 4.40 52.8 µM 2.07E-6 RPP1 & pyrimidine depletion 25 5.33E-6
7 SGTC_2055 5235184 3.94 200.0 µM 1.88E-5 ERG2 31 4.12E-5
8 SGTC_2638 epoxomicin 3.88 18.0 µM 2.47E-5 38 5.31E-5
9 SGTC_1355 1499-0035 3.80 1.7 µM 3.51E-5 20 7.36E-5
10 SGTC_1871 st057448 3.69 67.3 µM 5.57E-5 32 1.13E-4
11 SGTC_2382 9035899 3.67 200.0 µM 5.96E-5 60S ribosome export 22 1.20E-4
12 SGTC_2262 9014885 3.66 67.5 µM 6.28E-5 6 1.26E-4
13 SGTC_1305 1181-0477 3.59 144.0 µM 8.34E-5 21 1.64E-4
14 SGTC_2312 7706453 3.49 155.7 µM 1.29E-4 41 2.46E-4
15 SGTC_1403 3909-7815 3.46 62.9 µM 1.42E-4 28 2.69E-4
16 SGTC_808 0711-0032 3.45 135.0 µM 1.49E-4 29 2.81E-4
17 SGTC_792 4534-1957 3.44 155.0 µM 1.54E-4 59 2.90E-4
18 SGTC_1492 4158-0558 3.44 28.5 µM 1.56E-4 60S ribosome export 25 2.94E-4
19 SGTC_624 k048-0052 3.37 28.0 µM 2.01E-4 Golgi 30 3.71E-4
20 SGTC_1014 4130-3005 3.32 69.3 µM 2.48E-4 42 4.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 4.01E-28 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.158 3.55E-20 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.154 3.13E-19 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.145 3.00E-17 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.137 1.43E-15 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.134 8.18E-15 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.133 1.31E-14 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.132 2.02E-14 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.123 9.99E-13 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.118 7.49E-12 YDR242W AMD2 hom Putative amidase
0.118 8.45E-12 YIR035C_p YIR035C_p hom Putative cytoplasmic short-chain dehydrogenase/reductase
0.117 1.17E-11 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.109 2.10E-10 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.104 1.68E-9 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.103 2.23E-9 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily