YNR073C_p

Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR073C / YNR073C

Click on Significant Values for Screen Details ID:SGTC_346|Compound:4513-0042|FD-Score:3.88|P-value:1.21E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.65|P-value:2.78E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.02|P-value:7.02E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.29|P-value:5.30E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.40|P-value:3.55E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.27|P-value:5.57E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.47|P-value:2.77E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.25|P-value:5.95E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.44|P-value:5.92E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.48|P-value:2.65E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.06|P-value:5.84E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-4.32|P-value:9.54E-6 ID:SGTC_2298|Compound:7976326|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2343|Compound:7990716|FD-Score:5.56|P-value:5.74E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.31|P-value:4.95E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:7.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.78|P-value:1.77E-8 ID:SGTC_3353|Compound:9151644|FD-Score:6.36|P-value:5.93E-10 ID:SGTC_346|Compound:4513-0042|FD-Score:3.88|P-value:1.21E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.65|P-value:2.78E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.02|P-value:7.02E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.29|P-value:5.30E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.40|P-value:3.55E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.27|P-value:5.57E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.47|P-value:2.77E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.25|P-value:5.95E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.44|P-value:5.92E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.48|P-value:2.65E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.06|P-value:5.84E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-4.32|P-value:9.54E-6 ID:SGTC_2298|Compound:7976326|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2343|Compound:7990716|FD-Score:5.56|P-value:5.74E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.31|P-value:4.95E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:7.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.78|P-value:1.77E-8 ID:SGTC_3353|Compound:9151644|FD-Score:6.36|P-value:5.93E-10

Top fitness defect scores for YNR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3353 9151644 6.36 39.3 µM 5.93E-10 1 9.77E-11
2 SGTC_3141 9094609 5.78 49.5 µM 1.77E-8 iron homeostasis 6 3.81E-9
3 SGTC_2343 7990716 5.56 14.8 µM 5.74E-8 3 1.35E-8
4 SGTC_1873 rapamycin 4.06 2.0 nM 5.84E-5 66 2.40E-5
5 SGTC_585 0kpi-0023 4.02 191.0 µM 7.02E-5 18 2.93E-5
6 SGTC_346 4513-0042 3.88 7.2 µM 1.21E-4 azole & statin 45 5.28E-5
7 SGTC_2112 5488546 3.79 200.0 µM 1.66E-4 TSC3-RPN4 21 7.44E-5
8 SGTC_363 0455-0021 3.65 3.1 µM 2.78E-4 azole & statin 78 1.30E-4
9 SGTC_1082 camptothecin 3.44 424.9 nM 5.92E-4 DNA damage response 64 2.96E-4
10 SGTC_573 3702-0553 3.13 84.7 µM 0.00161 40 8.73E-4
11 SGTC_3258 9138477 3.11 49.5 µM 0.00173 28 9.50E-4
12 SGTC_566 0958-0068 3.10 16.5 µM 0.00176 RSC & ERG11 45 9.62E-4
13 SGTC_748 0136-0228 3.05 77.9 µM 0.00207 redox potentiating 130 0.00115
14 SGTC_2911 7942208 3.03 15.6 µM 0.00221 mitochondrial response to ROS 39 0.00124
15 SGTC_1120 ficusin 3.02 1.8 µM 0.00223 59 0.00125
16 SGTC_1164 k060-0068 3.01 93.7 µM 0.00230 75 0.00129
17 SGTC_1990 st072050 2.99 59.8 µM 0.00248 50 0.00140
18 SGTC_3074 9116018 2.98 49.5 µM 0.00256 RNA processing & uracil transport 52 0.00145
19 SGTC_1831 st055328 2.94 12.0 µM 0.00288 heme biosynthesis & mitochondrial translocase 70 0.00165
20 SGTC_1986 st071812 2.94 45.0 µM 0.00291 37 0.00167

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.63E-10 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.102 2.96E-9 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.095 3.24E-8 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.091 1.30E-7 YHR132C ECM14 hom Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
0.088 2.94E-7 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.085 7.14E-7 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.084 1.17E-6 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.084 1.22E-6 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.083 1.29E-6 YGL201C MCM6 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
0.083 1.61E-6 YER038W-A_d YER038W-A_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
0.083 1.60E-6 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.082 1.92E-6 YKL089W MIF2 het Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
0.081 2.33E-6 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.081 2.49E-6 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.081 2.81E-6 YNL066W SUN4 hom Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family