YNR074C / AIF1

Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR074C / AIF1

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.93|P-value:4.15E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.07|P-value:9.89E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.79|P-value:8.12E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.32|P-value:5.02E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.71|P-value:1.18E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:4.13|P-value:1.82E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.24|P-value:5.49E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.35|P-value:3.72E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.19|P-value:7.22E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.89|P-value:4.87E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.28|P-value:4.76E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.58|P-value:1.52E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.34|P-value:3.82E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.58|P-value:1.53E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.39|P-value:3.19E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.44|P-value:2.89E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.49|P-value:2.40E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.57|P-value:1.77E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.64|P-value:1.21E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.53|P-value:2.90E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-4.58|P-value:1.94E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.34|P-value:6.95E-6 ID:SGTC_1688|Compound:st021091|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.18|P-value:1.47E-5 ID:SGTC_1916|Compound:st067606|FD-Score:5.84|P-value:2.52E-9 ID:SGTC_1936|Compound:st074407|FD-Score:4.85|P-value:5.93E-7 ID:SGTC_1944|Compound:st076371|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.08|P-value:2.24E-5 ID:SGTC_2030|Compound:5175110|FD-Score:5.77|P-value:3.68E-9 ID:SGTC_2031|Compound:5180455|FD-Score:-4.08|P-value:1.99E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.66|P-value:1.13E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.25|P-value:5.16E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.26|P-value:5.10E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.52|P-value:3.00E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.51|P-value:2.00E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.51|P-value:2.76E-6 ID:SGTC_3212|Compound:9128307|FD-Score:3.64|P-value:1.34E-4 ID:SGTC_3239|Compound:9133757|FD-Score:-3.45|P-value:2.50E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.93|P-value:4.15E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.07|P-value:9.89E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.79|P-value:8.12E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.32|P-value:5.02E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.71|P-value:1.18E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:4.13|P-value:1.82E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.24|P-value:5.49E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.35|P-value:3.72E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.19|P-value:7.22E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.89|P-value:4.87E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.28|P-value:4.76E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.58|P-value:1.52E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.34|P-value:3.82E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.58|P-value:1.53E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.39|P-value:3.19E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.44|P-value:2.89E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.49|P-value:2.40E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.57|P-value:1.77E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.64|P-value:1.21E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.53|P-value:2.90E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-4.58|P-value:1.94E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.34|P-value:6.95E-6 ID:SGTC_1688|Compound:st021091|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.18|P-value:1.47E-5 ID:SGTC_1916|Compound:st067606|FD-Score:5.84|P-value:2.52E-9 ID:SGTC_1936|Compound:st074407|FD-Score:4.85|P-value:5.93E-7 ID:SGTC_1944|Compound:st076371|FD-Score:3.33|P-value:4.42E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.08|P-value:2.24E-5 ID:SGTC_2030|Compound:5175110|FD-Score:5.77|P-value:3.68E-9 ID:SGTC_2031|Compound:5180455|FD-Score:-4.08|P-value:1.99E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.66|P-value:1.13E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.65|P-value:1.33E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-3.25|P-value:5.16E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.26|P-value:5.10E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.52|P-value:3.00E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.30|P-value:4.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.51|P-value:2.00E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.51|P-value:2.76E-6 ID:SGTC_3212|Compound:9128307|FD-Score:3.64|P-value:1.34E-4 ID:SGTC_3239|Compound:9133757|FD-Score:-3.45|P-value:2.50E-4

Top fitness defect scores for YNR074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1916 st067606 5.84 49.2 µM 2.52E-9 8 2.66E-9
2 SGTC_2030 5175110 5.77 200.0 µM 3.68E-9 Golgi 6 3.88E-9
3 SGTC_142 0335-0849 5.32 62.7 µM 5.02E-8 ubiquinone biosynthesis & proteasome 79 5.22E-8
4 SGTC_541 4513-1321 4.89 94.0 µM 4.87E-7 10 5.00E-7
5 SGTC_1936 st074407 4.85 74.3 µM 5.93E-7 DNA damage response 15 6.08E-7
6 SGTC_137 0438-0332 4.79 85.4 µM 8.12E-7 ubiquinone biosynthesis & proteasome 81 8.32E-7
7 SGTC_158 k038-0087 4.71 26.4 µM 1.18E-6 ubiquinone biosynthesis & proteasome 98 1.21E-6
8 SGTC_1633 st005664 4.53 67.9 µM 2.90E-6 19 2.95E-6
9 SGTC_2693 st077581 4.52 40.7 µM 3.00E-6 18 3.06E-6
10 SGTC_1638 st008370 4.34 60.6 µM 6.95E-6 ergosterol biosynthesis 25 7.05E-6
11 SGTC_1908 st060353 4.18 56.5 µM 1.47E-5 RPP1 & pyrimidine depletion 30 1.48E-5
12 SGTC_259 usnic acid 4.13 108.9 µM 1.82E-5 14 1.83E-5
13 SGTC_2000 st075254 4.08 36.4 µM 2.24E-5 6 2.26E-5
14 SGTC_86 0417-1630 3.93 471.9 µM 4.15E-5 ubiquinone biosynthesis & proteasome 151 4.18E-5
15 SGTC_2367 9070478 3.65 135.4 µM 1.33E-4 cell wall 45 1.33E-4
16 SGTC_3212 9128307 3.64 49.5 µM 1.34E-4 60 1.34E-4
17 SGTC_1688 st021091 3.58 57.6 µM 1.69E-4 12 1.69E-4
18 SGTC_1324 1418-0026 3.57 34.4 µM 1.77E-4 21 1.76E-4
19 SGTC_1153 4055-0057 3.49 267.0 µM 2.40E-4 45 2.39E-4
20 SGTC_1148 3909-7663 3.44 27.7 µM 2.89E-4 27 2.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 1.90E-42 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.224 1.38E-39 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.220 3.39E-38 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.218 2.84E-37 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.202 4.40E-32 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.183 9.73E-27 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.176 1.03E-24 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.174 2.74E-24 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.174 4.23E-24 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.171 1.74E-23 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.169 8.52E-23 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.167 2.12E-22 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.166 3.23E-22 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.166 4.84E-22 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.164 1.26E-21 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding