YOL001W / PHO80

Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL001W / PHO80

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:9.48|P-value:4.80E-17 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.26|P-value:9.12E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.29|P-value:8.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.40|P-value:1.27E-23 ID:SGTC_232|Compound:clozapine|FD-Score:4.62|P-value:2.62E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.84|P-value:3.87E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.27|P-value:9.30E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.17|P-value:1.31E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:1.54E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.82|P-value:1.75E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:7.73|P-value:6.32E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.69|P-value:6.18E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.87|P-value:9.99E-6 ID:SGTC_470|Compound:aa-861|FD-Score:3.85|P-value:3.79E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.69|P-value:2.03E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:4.85|P-value:1.09E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.88|P-value:9.84E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:5.87|P-value:1.35E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:5.47|P-value:8.19E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:8.25|P-value:2.47E-13 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:4.42E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.50|P-value:4.12E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:4.08|P-value:1.78E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:8.99|P-value:1.73E-15 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.97|P-value:2.54E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.72|P-value:5.71E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.75|P-value:4.93E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:5.10|P-value:4.08E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.72|P-value:5.68E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.88|P-value:8.91E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:8.95|P-value:2.20E-15 ID:SGTC_1403|Compound:3909-7815|FD-Score:7.66|P-value:9.49E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.44|P-value:5.08E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.16|P-value:1.36E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.93|P-value:1.81E-12 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.88|P-value:3.38E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.65|P-value:6.58E-4 ID:SGTC_1667|Compound:st014849|FD-Score:5.17|P-value:3.01E-6 ID:SGTC_1687|Compound:st020778|FD-Score:6.66|P-value:2.66E-9 ID:SGTC_1721|Compound:st082152|FD-Score:13.90|P-value:2.45E-34 ID:SGTC_1750|Compound:st081859|FD-Score:11.20|P-value:3.32E-23 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.81|P-value:4.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.76|P-value:4.96E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.41|P-value:4.30E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.42|P-value:9.45E-9 ID:SGTC_1912|Compound:st060209|FD-Score:-4.79|P-value:1.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:1.52E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.11|P-value:3.85E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.70|P-value:1.92E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-3.97|P-value:2.43E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.54|P-value:3.55E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.95|P-value:7.38E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.64|P-value:6.84E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.96|P-value:2.62E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.21|P-value:2.49E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.79|P-value:4.55E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.95|P-value:2.74E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.23|P-value:1.06E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.36|P-value:6.89E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.92|P-value:2.81E-15 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.59|P-value:4.90E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.84|P-value:3.94E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.14|P-value:3.78E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.56|P-value:9.11E-4 ID:SGTC_2701|Compound:st077767|FD-Score:6.96|P-value:5.30E-10 ID:SGTC_2710|Compound:st078562|FD-Score:4.52|P-value:3.75E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.52|P-value:3.80E-5 ID:SGTC_2715|Compound:st079500|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.54|P-value:9.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.10|P-value:4.75E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.67|P-value:3.39E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.85|P-value:1.09E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.12|P-value:1.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:11.20|P-value:3.39E-23 ID:SGTC_2838|Compound:9002687|FD-Score:5.57|P-value:5.36E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.15|P-value:1.33E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.63|P-value:1.20E-11 ID:SGTC_2918|Compound:7977171|FD-Score:4.57|P-value:3.12E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.02|P-value:2.21E-4 ID:SGTC_3022|Compound:9087993|FD-Score:4.80|P-value:1.34E-5 ID:SGTC_3025|Compound:9087895|FD-Score:3.98|P-value:2.51E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.08|P-value:1.79E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.86|P-value:3.60E-4 ID:SGTC_3291|Compound:9121177|FD-Score:4.70|P-value:1.97E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.68|P-value:6.45E-4 ID:SGTC_3322|Compound:9139058|FD-Score:5.40|P-value:1.14E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:9.48|P-value:4.80E-17 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.26|P-value:9.12E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.29|P-value:8.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.40|P-value:1.27E-23 ID:SGTC_232|Compound:clozapine|FD-Score:4.62|P-value:2.62E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.84|P-value:3.87E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.27|P-value:9.30E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.17|P-value:1.31E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:1.54E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.82|P-value:1.75E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:7.73|P-value:6.32E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.69|P-value:6.18E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.87|P-value:9.99E-6 ID:SGTC_470|Compound:aa-861|FD-Score:3.85|P-value:3.79E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.69|P-value:2.03E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:4.85|P-value:1.09E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.88|P-value:9.84E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:5.87|P-value:1.35E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:5.47|P-value:8.19E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:8.25|P-value:2.47E-13 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:4.42E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.50|P-value:4.12E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:4.08|P-value:1.78E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:8.99|P-value:1.73E-15 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.97|P-value:2.54E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.72|P-value:5.71E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.75|P-value:4.93E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:5.10|P-value:4.08E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.72|P-value:5.68E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.88|P-value:8.91E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:8.95|P-value:2.20E-15 ID:SGTC_1403|Compound:3909-7815|FD-Score:7.66|P-value:9.49E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.44|P-value:5.08E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.16|P-value:1.36E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.93|P-value:1.81E-12 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.88|P-value:3.38E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.65|P-value:6.58E-4 ID:SGTC_1667|Compound:st014849|FD-Score:5.17|P-value:3.01E-6 ID:SGTC_1687|Compound:st020778|FD-Score:6.66|P-value:2.66E-9 ID:SGTC_1721|Compound:st082152|FD-Score:13.90|P-value:2.45E-34 ID:SGTC_1750|Compound:st081859|FD-Score:11.20|P-value:3.32E-23 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.81|P-value:4.30E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.76|P-value:4.96E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.41|P-value:4.30E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.42|P-value:9.45E-9 ID:SGTC_1912|Compound:st060209|FD-Score:-4.79|P-value:1.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:1.52E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.11|P-value:3.85E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.70|P-value:1.92E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-3.97|P-value:2.43E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.54|P-value:3.55E-5 ID:SGTC_2300|Compound:7976697|FD-Score:4.95|P-value:7.38E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.64|P-value:6.84E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.96|P-value:2.62E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.21|P-value:2.49E-6 ID:SGTC_2482|Compound:5981709|FD-Score:3.79|P-value:4.55E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.95|P-value:2.74E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.23|P-value:1.06E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.36|P-value:6.89E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.92|P-value:3.05E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:8.92|P-value:2.81E-15 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.59|P-value:4.90E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.84|P-value:3.94E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.14|P-value:3.78E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.56|P-value:9.11E-4 ID:SGTC_2701|Compound:st077767|FD-Score:6.96|P-value:5.30E-10 ID:SGTC_2710|Compound:st078562|FD-Score:4.52|P-value:3.75E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.52|P-value:3.80E-5 ID:SGTC_2715|Compound:st079500|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.54|P-value:9.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.10|P-value:4.75E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.67|P-value:3.39E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.85|P-value:1.09E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.12|P-value:1.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:11.20|P-value:3.39E-23 ID:SGTC_2838|Compound:9002687|FD-Score:5.57|P-value:5.36E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.15|P-value:1.33E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.63|P-value:1.20E-11 ID:SGTC_2918|Compound:7977171|FD-Score:4.57|P-value:3.12E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.02|P-value:2.21E-4 ID:SGTC_3022|Compound:9087993|FD-Score:4.80|P-value:1.34E-5 ID:SGTC_3025|Compound:9087895|FD-Score:3.98|P-value:2.51E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.08|P-value:1.79E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.86|P-value:3.60E-4 ID:SGTC_3291|Compound:9121177|FD-Score:4.70|P-value:1.97E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.68|P-value:6.45E-4 ID:SGTC_3322|Compound:9139058|FD-Score:5.40|P-value:1.14E-6

Top fitness defect scores for YOL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1721 st082152 13.90 9.3 µM 2.45E-34 60S ribosome export 1 4.35E-44
2 SGTC_221 trifluoperazine 11.40 10.3 µM 1.27E-23 NEO1-PIK1 44 3.58E-30
3 SGTC_1750 st081859 11.20 2.4 µM 3.32E-23 endomembrane recycling 32 1.24E-29
4 SGTC_2790 5423970 11.20 71.4 µM 3.39E-23 endomembrane recycling 8 1.28E-29
5 SGTC_2752 diclazuril 10.10 33.1 µM 4.75E-19 23 3.07E-24
6 SGTC_143 4032-1194 9.48 15.7 µM 4.80E-17 5 1.23E-21
7 SGTC_955 1216-0110 8.99 33.0 µM 1.73E-15 sphingolipid biosynthesis & PDR1 16 1.28E-19
8 SGTC_1375 2910-0797 8.95 186.0 µM 2.20E-15 1 1.76E-19
9 SGTC_2567 aureobasidin a 8.92 60.0 nM 2.81E-15 17 2.41E-19
10 SGTC_841 0251-0215 8.25 91.2 µM 2.47E-13 19 7.98E-17
11 SGTC_1573 oleylamine 7.93 1.1 µM 1.81E-12 4 1.05E-15
12 SGTC_350 k064-0020 7.73 19.8 µM 6.32E-12 heme requiring 4 5.32E-15
13 SGTC_1403 3909-7815 7.66 62.9 µM 9.49E-12 4 9.01E-15
14 SGTC_2858 9025781 7.63 9.0 µM 1.20E-11 sphingolipid biosynthesis & PDR1 31 1.22E-14
15 SGTC_1873 rapamycin 7.41 2.0 nM 4.30E-11 15 6.37E-14
16 SGTC_2701 st077767 6.96 14.7 µM 5.30E-10 8 1.65E-12
17 SGTC_1687 st020778 6.66 55.4 µM 2.66E-9 95 1.33E-11
18 SGTC_1877 wortmannin 6.42 25.0 µM 9.45E-9 42 6.86E-11
19 SGTC_2679 rapamycin 6.14 1.0 nM 3.78E-8 72 4.12E-10
20 SGTC_598 3937-0236 5.87 20.2 µM 1.35E-7 ERG2 8 2.13E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.27E-51 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.237 5.31E-44 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.234 5.37E-43 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.221 2.41E-38 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.215 2.47E-36 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.215 3.24E-36 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.209 1.56E-34 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.208 2.85E-34 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.197 1.05E-30 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.197 9.00E-31 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.196 1.65E-30 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.196 2.24E-30 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.196 2.57E-30 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.195 3.63E-30 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.190 1.33E-28 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments