YOL002C / IZH2

Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL002C / IZH2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:2.36E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:14.00|P-value:6.87E-47 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.12|P-value:6.65E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.51|P-value:1.94E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:10.00|P-value:5.89E-25 ID:SGTC_373|Compound:0844-0104|FD-Score:10.30|P-value:1.87E-26 ID:SGTC_384|Compound:k007-0144|FD-Score:13.00|P-value:1.32E-40 ID:SGTC_426|Compound:0988-0037|FD-Score:3.41|P-value:2.44E-4 ID:SGTC_444|Compound:curcumin|FD-Score:5.27|P-value:3.38E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:13.40|P-value:4.96E-43 ID:SGTC_570|Compound:0987-0065|FD-Score:3.11|P-value:7.46E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:5.54|P-value:6.98E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:6.18|P-value:1.22E-10 ID:SGTC_660|Compound:4031-1742|FD-Score:5.05|P-value:1.18E-7 ID:SGTC_675|Compound:1309-0189|FD-Score:4.26|P-value:6.49E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:4.27|P-value:6.25E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.24|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:18.50|P-value:6.82E-81 ID:SGTC_795|Compound:0685-0265|FD-Score:4.03|P-value:1.83E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:8.59|P-value:6.94E-19 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:8.75E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.74|P-value:6.40E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.77|P-value:5.27E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:19.50|P-value:1.93E-89 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.91|P-value:2.45E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.40|P-value:7.67E-27 ID:SGTC_1165|Compound:k072-0275|FD-Score:7.10|P-value:1.77E-13 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.02|P-value:1.93E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.97|P-value:4.79E-10 ID:SGTC_1660|Compound:st012960|FD-Score:3.99|P-value:2.24E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.67|P-value:8.58E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.95|P-value:2.63E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.20|P-value:8.53E-6 ID:SGTC_2012|Compound:4023501|FD-Score:-3.84|P-value:3.91E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.32|P-value:3.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.16|P-value:5.84E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.02|P-value:9.34E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.09|P-value:8.04E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.12|P-value:6.58E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.04|P-value:1.78E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_2322|Compound:7413319|FD-Score:12.70|P-value:6.78E-39 ID:SGTC_2328|Compound:6201408|FD-Score:-3.01|P-value:9.76E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.42|P-value:2.31E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.16|P-value:5.86E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.22|P-value:4.96E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.03|P-value:1.90E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-5.78|P-value:1.46E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.56|P-value:1.37E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:12.30|P-value:1.40E-36 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.12|P-value:7.01E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.28|P-value:4.04E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.50|P-value:2.08E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.40|P-value:3.36E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-4.80|P-value:4.07E-7 ID:SGTC_3155|Compound:9099265|FD-Score:-3.52|P-value:1.46E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.20|P-value:5.34E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.83|P-value:4.51E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.48|P-value:2.25E-6 ID:SGTC_3348|Compound:9149464|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-5.51|P-value:7.50E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:3.98|P-value:2.36E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:14.00|P-value:6.87E-47 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.12|P-value:6.65E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.51|P-value:1.94E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:10.00|P-value:5.89E-25 ID:SGTC_373|Compound:0844-0104|FD-Score:10.30|P-value:1.87E-26 ID:SGTC_384|Compound:k007-0144|FD-Score:13.00|P-value:1.32E-40 ID:SGTC_426|Compound:0988-0037|FD-Score:3.41|P-value:2.44E-4 ID:SGTC_444|Compound:curcumin|FD-Score:5.27|P-value:3.38E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:13.40|P-value:4.96E-43 ID:SGTC_570|Compound:0987-0065|FD-Score:3.11|P-value:7.46E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:5.54|P-value:6.98E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:6.18|P-value:1.22E-10 ID:SGTC_660|Compound:4031-1742|FD-Score:5.05|P-value:1.18E-7 ID:SGTC_675|Compound:1309-0189|FD-Score:4.26|P-value:6.49E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:4.27|P-value:6.25E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.24|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.39|P-value:2.66E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:18.50|P-value:6.82E-81 ID:SGTC_795|Compound:0685-0265|FD-Score:4.03|P-value:1.83E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:8.59|P-value:6.94E-19 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:8.75E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.74|P-value:6.40E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.67|P-value:8.61E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.77|P-value:5.27E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:19.50|P-value:1.93E-89 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.91|P-value:2.45E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.40|P-value:7.67E-27 ID:SGTC_1165|Compound:k072-0275|FD-Score:7.10|P-value:1.77E-13 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.02|P-value:1.93E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.25|P-value:4.41E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.97|P-value:4.79E-10 ID:SGTC_1660|Compound:st012960|FD-Score:3.99|P-value:2.24E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.67|P-value:8.58E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.95|P-value:2.63E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.20|P-value:8.53E-6 ID:SGTC_2012|Compound:4023501|FD-Score:-3.84|P-value:3.91E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.32|P-value:3.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.16|P-value:5.84E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.02|P-value:9.34E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.09|P-value:8.04E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.12|P-value:6.58E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.04|P-value:1.78E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_2322|Compound:7413319|FD-Score:12.70|P-value:6.78E-39 ID:SGTC_2328|Compound:6201408|FD-Score:-3.01|P-value:9.76E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.42|P-value:2.31E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.16|P-value:5.86E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.22|P-value:4.96E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.03|P-value:1.90E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-5.78|P-value:1.46E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.56|P-value:1.37E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:12.30|P-value:1.40E-36 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.12|P-value:7.01E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.28|P-value:4.04E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.50|P-value:2.08E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.40|P-value:3.36E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-4.80|P-value:4.07E-7 ID:SGTC_3155|Compound:9099265|FD-Score:-3.52|P-value:1.46E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.20|P-value:5.34E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.83|P-value:4.51E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.48|P-value:2.25E-6 ID:SGTC_3348|Compound:9149464|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-5.51|P-value:7.50E-9

Top fitness defect scores for YOL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1026 k007-1105 19.50 30.6 µM 1.93E-89 ERAD & cell cycle 2 3.13E-85
2 SGTC_733 4069-0007 18.50 56.1 µM 6.82E-81 ERAD & cell cycle 4 4.25E-77
3 SGTC_103 0844-0104 14.00 51.8 µM 6.87E-47 ERAD & cell cycle 11 9.64E-45
4 SGTC_568 1193-0097 13.40 7.5 µM 4.96E-43 ERAD & cell cycle 7 4.53E-41
5 SGTC_384 k007-0144 13.00 5.2 µM 1.32E-40 ERAD & cell cycle 5 9.22E-39
6 SGTC_2322 7413319 12.70 38.2 µM 6.78E-39 ERAD & cell cycle 8 3.91E-37
7 SGTC_2597 laccaic acid a 12.30 100.0 µM 1.40E-36 1 6.27E-35
8 SGTC_1161 k007-0610 10.40 110.0 µM 7.67E-27 ERAD & cell cycle 12 1.17E-25
9 SGTC_373 0844-0104 10.30 25.9 µM 1.87E-26 ERAD & cell cycle 7 2.73E-25
10 SGTC_352 k048-0007 10.00 5.1 µM 5.89E-25 ERAD & cell cycle 9 7.28E-24
11 SGTC_805 3852-0218 8.59 479.0 µM 6.94E-19 ERAD & cell cycle 7 4.40E-18
12 SGTC_1165 k072-0275 7.10 30.3 µM 1.77E-13 6 6.24E-13
13 SGTC_637 1181-0519 6.18 7.3 µM 1.22E-10 fatty acid desaturase (OLE1) 50 3.15E-10
14 SGTC_1658 st012944 5.97 20.0 µM 4.79E-10 iron homeostasis 29 1.16E-9
15 SGTC_603 3794-0023 5.54 45.9 µM 6.98E-9 4 1.50E-8
16 SGTC_444 curcumin 5.27 90.4 µM 3.38E-8 iron homeostasis 9 6.73E-8
17 SGTC_660 4031-1742 5.05 102.0 µM 1.18E-7 redox potentiating 20 2.21E-7
18 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.91 1.2 µM 2.45E-7 iron homeostasis 26 4.45E-7
19 SGTC_1024 4507-0395 4.77 26.0 µM 5.27E-7 TSC3-RPN4 14 9.25E-7
20 SGTC_157 1348-1695 4.51 65.8 µM 1.94E-6 iron homeostasis 44 3.22E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.676 0 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.538 1.06E-250 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.530 4.65E-243 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.518 6.56E-230 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.513 3.34E-225 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.441 6.06E-160 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.423 1.06E-145 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.412 4.61E-138 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.402 1.33E-130 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.387 4.52E-120 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.374 5.35E-112 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.354 1.11E-99 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.345 1.31E-94 YDR200C VPS64 hom Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance
0.343 5.80E-93 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.338 1.55E-90 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress