YOL004W / SIN3

Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL004W / SIN3

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.66|P-value:1.37E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.91|P-value:3.91E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:7.23|P-value:1.69E-13 ID:SGTC_90|Compound:0870-0863|FD-Score:9.62|P-value:1.69E-22 ID:SGTC_103|Compound:0844-0104|FD-Score:5.04|P-value:1.95E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.06|P-value:9.92E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.08|P-value:2.03E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.63|P-value:1.46E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:5.18|P-value:9.54E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:8.82|P-value:3.41E-19 ID:SGTC_200|Compound:k038-0079|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.38|P-value:3.40E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.33|P-value:4.11E-4 ID:SGTC_263|Compound:alizarin|FD-Score:7.93|P-value:7.12E-16 ID:SGTC_294|Compound:k038-0071|FD-Score:3.25|P-value:5.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.11|P-value:9.06E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.81|P-value:6.41E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.51|P-value:2.92E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:6.37|P-value:7.15E-11 ID:SGTC_708|Compound:3448-5400|FD-Score:4.97|P-value:2.94E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.52|P-value:2.75E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:3.18|P-value:7.06E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.89|P-value:4.32E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:4.17|P-value:1.36E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.91|P-value:4.00E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.80|P-value:6.71E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.91|P-value:1.76E-12 ID:SGTC_1522|Compound:st012842|FD-Score:3.50|P-value:2.19E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.30|P-value:4.60E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.53|P-value:2.66E-6 ID:SGTC_1608|Compound:st001473|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.74|P-value:8.61E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.15|P-value:7.90E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.72|P-value:8.32E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.44|P-value:2.77E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.79|P-value:7.05E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.09|P-value:9.59E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.23|P-value:5.78E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.68|P-value:1.26E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.47|P-value:2.28E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.63|P-value:1.09E-11 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:6.01|P-value:7.42E-10 ID:SGTC_2845|Compound:9003024|FD-Score:5.31|P-value:4.66E-8 ID:SGTC_2896|Compound:9052656|FD-Score:3.19|P-value:6.84E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.33|P-value:4.03E-8 ID:SGTC_2982|Compound:9019404|FD-Score:3.16|P-value:7.58E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.76|P-value:8.41E-7 ID:SGTC_3028|Compound:9087778|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.21|P-value:6.21E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.45|P-value:3.82E-6 ID:SGTC_3149|Compound:9097855|FD-Score:-3.69|P-value:9.51E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.46|P-value:2.36E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.36|P-value:3.37E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.66|P-value:1.37E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.91|P-value:3.91E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:7.23|P-value:1.69E-13 ID:SGTC_90|Compound:0870-0863|FD-Score:9.62|P-value:1.69E-22 ID:SGTC_103|Compound:0844-0104|FD-Score:5.04|P-value:1.95E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.06|P-value:9.92E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.08|P-value:2.03E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.38|P-value:3.47E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-4.63|P-value:1.46E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:5.18|P-value:9.54E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:8.82|P-value:3.41E-19 ID:SGTC_200|Compound:k038-0079|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.38|P-value:3.40E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.33|P-value:4.11E-4 ID:SGTC_263|Compound:alizarin|FD-Score:7.93|P-value:7.12E-16 ID:SGTC_294|Compound:k038-0071|FD-Score:3.25|P-value:5.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.11|P-value:9.06E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.81|P-value:6.41E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.51|P-value:2.92E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:6.37|P-value:7.15E-11 ID:SGTC_708|Compound:3448-5400|FD-Score:4.97|P-value:2.94E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.52|P-value:2.75E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:3.18|P-value:7.06E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.30|P-value:4.53E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.89|P-value:4.32E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:4.17|P-value:1.36E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.22|P-value:1.12E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.12|P-value:8.66E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.91|P-value:4.00E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.80|P-value:6.71E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.57|P-value:1.70E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.91|P-value:1.76E-12 ID:SGTC_1522|Compound:st012842|FD-Score:3.50|P-value:2.19E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.30|P-value:4.60E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.53|P-value:2.66E-6 ID:SGTC_1608|Compound:st001473|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.74|P-value:8.61E-5 ID:SGTC_1776|Compound:st049249|FD-Score:3.15|P-value:7.90E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.72|P-value:8.32E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.44|P-value:2.77E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.79|P-value:7.05E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.09|P-value:9.59E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.23|P-value:5.78E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.68|P-value:1.26E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.47|P-value:2.28E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.63|P-value:1.09E-11 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:6.01|P-value:7.42E-10 ID:SGTC_2845|Compound:9003024|FD-Score:5.31|P-value:4.66E-8 ID:SGTC_2896|Compound:9052656|FD-Score:3.19|P-value:6.84E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.33|P-value:4.03E-8 ID:SGTC_2982|Compound:9019404|FD-Score:3.16|P-value:7.58E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.76|P-value:8.41E-7 ID:SGTC_3028|Compound:9087778|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.21|P-value:6.21E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.45|P-value:3.82E-6 ID:SGTC_3149|Compound:9097855|FD-Score:-3.69|P-value:9.51E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.46|P-value:2.36E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.36|P-value:3.37E-4

Top fitness defect scores for YOL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_90 0870-0863 9.62 4.6 µM 1.69E-22 8 3.21E-22
2 SGTC_158 k038-0087 8.82 26.4 µM 3.41E-19 ubiquinone biosynthesis & proteasome 37 5.80E-19
3 SGTC_263 alizarin 7.93 107.9 µM 7.12E-16 iron homeostasis 11 1.09E-15
4 SGTC_86 0417-1630 7.23 471.9 µM 1.69E-13 ubiquinone biosynthesis & proteasome 69 2.39E-13
5 SGTC_1505 k297-0037 6.91 20.6 µM 1.76E-12 3 2.40E-12
6 SGTC_439 amiodarone 6.37 34.4 µM 7.15E-11 NEO1-PIK1 42 9.28E-11
7 SGTC_2588 indole-3-carbinol 6.01 100.0 µM 7.42E-10 9 9.32E-10
8 SGTC_2918 7977171 5.33 22.1 µM 4.03E-8 10 4.79E-8
9 SGTC_2845 9003024 5.31 43.0 µM 4.66E-8 amide catabolism 21 5.54E-8
10 SGTC_156 3474-0145 5.18 5.6 µM 9.54E-8 endomembrane recycling 30 1.12E-7
11 SGTC_103 0844-0104 5.04 51.8 µM 1.95E-7 ERAD & cell cycle 100 2.28E-7
12 SGTC_708 3448-5400 4.97 146.0 µM 2.94E-7 18 3.41E-7
13 SGTC_79 0052-0007 4.91 94.1 µM 3.91E-7 18 4.52E-7
14 SGTC_1078 idebenone 4.91 36.1 µM 4.00E-7 Golgi 21 4.62E-7
15 SGTC_916 4466-0038 4.89 42.0 nM 4.32E-7 cell wall 40 4.98E-7
16 SGTC_2993 9054257 4.76 71.4 µM 8.41E-7 fatty acid desaturase (OLE1) 24 9.62E-7
17 SGTC_2289 7946404 4.68 165.1 µM 1.26E-6 69 1.44E-6
18 SGTC_58 0957-0393 4.66 9.0 µM 1.37E-6 cell wall 317 1.55E-6
19 SGTC_1559 coumarin 343 4.53 70.1 µM 2.66E-6 4 3.00E-6
20 SGTC_794 k038-0031 4.52 316.0 µM 2.75E-6 ubiquinone biosynthesis & proteasome 91 3.09E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.310 1.71E-75 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.307 4.18E-74 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.306 1.47E-73 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.304 7.40E-73 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.300 6.80E-71 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.270 3.39E-57 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.269 1.25E-56 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.268 1.80E-56 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.267 6.31E-56 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.263 3.36E-54 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.262 1.59E-53 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.254 1.25E-50 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.254 1.32E-50 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.254 1.82E-50 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.254 2.07E-50 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder