YOL008W / COQ10

Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL008W / COQ10

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:7.42|P-value:1.43E-13 ID:SGTC_64|Compound:000l-0018|FD-Score:8.51|P-value:2.79E-17 ID:SGTC_67|Compound:0335-0847|FD-Score:6.18|P-value:5.70E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:16.60|P-value:5.51E-60 ID:SGTC_137|Compound:0438-0332|FD-Score:6.61|P-value:3.78E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:11.40|P-value:2.58E-29 ID:SGTC_158|Compound:k038-0087|FD-Score:10.90|P-value:7.82E-27 ID:SGTC_165|Compound:k038-0023|FD-Score:3.31|P-value:5.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.84|P-value:6.04E-15 ID:SGTC_340|Compound:k038-0059|FD-Score:5.16|P-value:1.79E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:8.62|P-value:1.17E-17 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.81|P-value:8.17E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.24|P-value:1.81E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.87|P-value:6.39E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.50|P-value:2.60E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.71|P-value:1.96E-11 ID:SGTC_726|Compound:3448-4391|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.82|P-value:1.09E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:6.70E-9 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.39|P-value:5.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.01|P-value:3.72E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.27|P-value:5.89E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-10.10|P-value:2.90E-23 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.90|P-value:1.01E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.24|P-value:8.80E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-8.77|P-value:6.64E-18 ID:SGTC_931|Compound:2812-0076|FD-Score:-8.65|P-value:1.84E-17 ID:SGTC_934|Compound:2950-0684|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:11.00|P-value:1.88E-27 ID:SGTC_937|Compound:3122-0005|FD-Score:8.17|P-value:4.56E-16 ID:SGTC_938|Compound:3126-1755|FD-Score:5.48|P-value:3.29E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.25|P-value:6.32E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.64|P-value:1.60E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.41|P-value:6.68E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.70|P-value:1.23E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.87|P-value:7.55E-7 ID:SGTC_1635|Compound:st007035|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:3.91E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.66|P-value:1.18E-8 ID:SGTC_2002|Compound:4023503|FD-Score:3.14|P-value:9.28E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.44|P-value:3.22E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.08|P-value:2.71E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.84|P-value:8.76E-7 ID:SGTC_2253|Compound:7938677|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.50|P-value:2.64E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.69|P-value:1.83E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.03|P-value:3.43E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.77|P-value:1.33E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.29|P-value:5.51E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.42|P-value:1.43E-13 ID:SGTC_64|Compound:000l-0018|FD-Score:8.51|P-value:2.79E-17 ID:SGTC_67|Compound:0335-0847|FD-Score:6.18|P-value:5.70E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:16.60|P-value:5.51E-60 ID:SGTC_137|Compound:0438-0332|FD-Score:6.61|P-value:3.78E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:11.40|P-value:2.58E-29 ID:SGTC_158|Compound:k038-0087|FD-Score:10.90|P-value:7.82E-27 ID:SGTC_165|Compound:k038-0023|FD-Score:3.31|P-value:5.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.84|P-value:6.04E-15 ID:SGTC_340|Compound:k038-0059|FD-Score:5.16|P-value:1.79E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:8.62|P-value:1.17E-17 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.81|P-value:8.17E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.24|P-value:1.81E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.87|P-value:6.39E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.50|P-value:2.60E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.71|P-value:1.96E-11 ID:SGTC_726|Compound:3448-4391|FD-Score:3.39|P-value:3.87E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.82|P-value:1.09E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:6.70E-9 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.39|P-value:5.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.01|P-value:3.72E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.27|P-value:5.89E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-10.10|P-value:2.90E-23 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.90|P-value:1.01E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.24|P-value:8.80E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-8.77|P-value:6.64E-18 ID:SGTC_931|Compound:2812-0076|FD-Score:-8.65|P-value:1.84E-17 ID:SGTC_934|Compound:2950-0684|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:11.00|P-value:1.88E-27 ID:SGTC_937|Compound:3122-0005|FD-Score:8.17|P-value:4.56E-16 ID:SGTC_938|Compound:3126-1755|FD-Score:5.48|P-value:3.29E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.25|P-value:6.32E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.64|P-value:1.60E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.41|P-value:6.68E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.62|P-value:1.68E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.70|P-value:1.23E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.87|P-value:7.55E-7 ID:SGTC_1635|Compound:st007035|FD-Score:3.27|P-value:5.92E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.28|P-value:5.70E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:3.91E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.66|P-value:1.18E-8 ID:SGTC_2002|Compound:4023503|FD-Score:3.14|P-value:9.28E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.44|P-value:3.22E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.08|P-value:2.71E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.84|P-value:8.76E-7 ID:SGTC_2253|Compound:7938677|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.17|P-value:8.46E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.50|P-value:2.64E-4 ID:SGTC_2384|Compound:9036245|FD-Score:4.69|P-value:1.83E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.57|P-value:2.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.03|P-value:3.43E-5 ID:SGTC_2808|Compound:7946468|FD-Score:-3.77|P-value:1.33E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.29|P-value:5.51E-4

Top fitness defect scores for YOL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 16.60 471.9 µM 5.51E-60 ubiquinone biosynthesis & proteasome 12 3.08E-62
2 SGTC_142 0335-0849 11.40 62.7 µM 2.58E-29 ubiquinone biosynthesis & proteasome 24 2.59E-30
3 SGTC_935 2996-0153 11.00 430.0 µM 1.88E-27 PDR1 1 2.23E-28
4 SGTC_158 k038-0087 10.90 26.4 µM 7.82E-27 ubiquinone biosynthesis & proteasome 29 9.84E-28
5 SGTC_386 1509-0011 8.62 3.1 µM 1.17E-17 55 3.37E-18
6 SGTC_64 000l-0018 8.51 272.1 µM 2.79E-17 ubiquinone biosynthesis & proteasome 44 8.33E-18
7 SGTC_937 3122-0005 8.17 46.7 µM 4.56E-16 2 1.52E-16
8 SGTC_236 1509-0011 7.84 5.3 µM 6.04E-15 254 2.22E-15
9 SGTC_36 0335-0881 7.42 14.2 µM 1.43E-13 ubiquinone biosynthesis & proteasome 42 5.91E-14
10 SGTC_635 k038-0028 6.71 24.7 µM 1.96E-11 ubiquinone biosynthesis & proteasome 11 9.79E-12
11 SGTC_137 0438-0332 6.61 85.4 µM 3.78E-11 ubiquinone biosynthesis & proteasome 55 1.93E-11
12 SGTC_67 0335-0847 6.18 266.0 µM 5.70E-10 ubiquinone biosynthesis & proteasome 65 3.22E-10
13 SGTC_794 k038-0031 5.76 316.0 µM 6.70E-9 ubiquinone biosynthesis & proteasome 59 4.13E-9
14 SGTC_1935 st074532 5.66 41.6 µM 1.18E-8 4 7.40E-9
15 SGTC_938 3126-1755 5.48 342.0 µM 3.29E-8 3 2.15E-8
16 SGTC_340 k038-0059 5.16 454.0 µM 1.79E-7 ubiquinone biosynthesis & proteasome 26 1.24E-7
17 SGTC_1445 4239-0156 4.87 97.7 µM 7.55E-7 8 5.49E-7
18 SGTC_2240 6690706 4.84 185.9 µM 8.76E-7 5 6.41E-7
19 SGTC_2384 9036245 4.69 200.0 µM 1.83E-6 20 1.37E-6
20 SGTC_1182 1222-0449 4.41 220.0 µM 6.68E-6 12 5.24E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.583 2.98E-305 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.566 4.93E-283 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.559 3.79E-275 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.539 3.79E-252 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.538 1.04E-250 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.527 6.28E-239 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.499 1.28E-210 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.482 2.58E-195 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.476 2.45E-189 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.476 3.08E-189 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.460 1.39E-175 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.457 1.32E-172 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.425 2.84E-147 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.416 1.13E-140 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.406 2.64E-133 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder