YOL009C / MDM12

Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL009C / MDM12

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.85|P-value:4.36E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.26|P-value:4.52E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.01|P-value:2.18E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:4.18|P-value:1.04E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.45|P-value:2.89E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.17|P-value:6.29E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.32|P-value:3.60E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:5.69|P-value:3.23E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.58|P-value:1.32E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.06|P-value:9.18E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.18|P-value:6.04E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.08|P-value:8.03E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.14|P-value:6.93E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.77|P-value:6.07E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:6.00|P-value:4.84E-10 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.23|P-value:5.01E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:6.26|P-value:8.63E-11 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.60|P-value:1.38E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.47|P-value:1.88E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.09|P-value:8.27E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:5.75|P-value:2.25E-9 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.82|P-value:4.97E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.13|P-value:7.28E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.05|P-value:9.40E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.21|P-value:8.14E-6 ID:SGTC_1982|Compound:st072467|FD-Score:4.54|P-value:1.87E-6 ID:SGTC_1985|Compound:st071382|FD-Score:4.41|P-value:3.53E-6 ID:SGTC_2059|Compound:5238311|FD-Score:7.76|P-value:1.27E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.16|P-value:6.60E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.83|P-value:4.71E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.95|P-value:2.83E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.20|P-value:5.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.25|P-value:4.66E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.72|P-value:7.54E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.41|P-value:2.56E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:4.22E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.85|P-value:4.39E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.15|P-value:1.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:9.23E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.53|P-value:1.52E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.41|P-value:2.35E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.04|P-value:1.37E-7 ID:SGTC_2884|Compound:9058502|FD-Score:4.31|P-value:5.66E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.12|P-value:1.23E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.11|P-value:7.79E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.88|P-value:3.82E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.10|P-value:7.92E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.91|P-value:2.49E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.12|P-value:6.96E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.23|P-value:8.15E-6 ID:SGTC_3240|Compound:9133527|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.11|P-value:7.67E-4 ID:SGTC_3289|Compound:9119912|FD-Score:5.15|P-value:7.82E-8 ID:SGTC_10|Compound:0279-0212|FD-Score:3.85|P-value:4.36E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.24|P-value:4.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.26|P-value:4.52E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.01|P-value:2.18E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:4.18|P-value:1.04E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.45|P-value:2.89E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.17|P-value:6.29E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.32|P-value:3.60E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:5.69|P-value:3.23E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.58|P-value:1.32E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.06|P-value:9.18E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.18|P-value:6.04E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.49|P-value:1.87E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.08|P-value:8.03E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.14|P-value:6.93E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.77|P-value:6.07E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:6.00|P-value:4.84E-10 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.23|P-value:5.01E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:6.26|P-value:8.63E-11 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.60|P-value:1.38E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.47|P-value:1.88E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.09|P-value:8.27E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:5.75|P-value:2.25E-9 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.82|P-value:4.97E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.13|P-value:7.28E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.05|P-value:9.40E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.21|P-value:8.14E-6 ID:SGTC_1982|Compound:st072467|FD-Score:4.54|P-value:1.87E-6 ID:SGTC_1985|Compound:st071382|FD-Score:4.41|P-value:3.53E-6 ID:SGTC_2059|Compound:5238311|FD-Score:7.76|P-value:1.27E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.16|P-value:6.60E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.83|P-value:4.71E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.95|P-value:2.83E-5 ID:SGTC_2319|Compound:6033012|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.20|P-value:5.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.25|P-value:4.66E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.72|P-value:7.54E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.41|P-value:2.56E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:4.22E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.85|P-value:4.39E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.15|P-value:1.21E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:9.23E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.53|P-value:1.52E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.41|P-value:2.35E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.04|P-value:1.37E-7 ID:SGTC_2884|Compound:9058502|FD-Score:4.31|P-value:5.66E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.12|P-value:1.23E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.11|P-value:7.79E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.88|P-value:3.82E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.10|P-value:7.92E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.91|P-value:2.49E-7 ID:SGTC_3137|Compound:9097352|FD-Score:-3.12|P-value:6.96E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.23|P-value:8.15E-6 ID:SGTC_3240|Compound:9133527|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.11|P-value:7.67E-4 ID:SGTC_3289|Compound:9119912|FD-Score:5.15|P-value:7.82E-8

Top fitness defect scores for YOL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2059 5238311 7.76 157.0 µM 1.27E-15 2 4.34E-15
2 SGTC_1198 1612-1005 6.26 86.7 µM 8.63E-11 1 1.91E-10
3 SGTC_1153 4055-0057 6.00 267.0 µM 4.84E-10 2 9.99E-10
4 SGTC_1271 0832-2808 5.75 169.0 µM 2.25E-9 1 4.38E-9
5 SGTC_314 1671-0008 5.69 2.7 µM 3.23E-9 9 6.20E-9
6 SGTC_3289 9119912 5.15 71.4 µM 7.82E-8 5 1.33E-7
7 SGTC_2700 st077718 5.04 96.8 µM 1.37E-7 2 2.28E-7
8 SGTC_1204 4049-0315 4.60 18.3 µM 1.38E-6 10 2.10E-6
9 SGTC_1982 st072467 4.54 71.9 µM 1.87E-6 21 2.81E-6
10 SGTC_236 1509-0011 4.45 5.3 µM 2.89E-6 360 4.28E-6
11 SGTC_1985 st071382 4.41 65.5 µM 3.53E-6 13 5.19E-6
12 SGTC_2884 9058502 4.31 52.0 µM 5.66E-6 20 8.18E-6
13 SGTC_3194 9111903 4.23 49.5 µM 8.15E-6 19 1.16E-5
14 SGTC_141 0443-0274 4.18 32.3 µM 1.04E-5 mitochondrial response to ROS 37 1.47E-5
15 SGTC_2687 chenodiol 4.15 100.0 µM 1.21E-5 19 1.70E-5
16 SGTC_1696 st025591 4.05 34.8 µM 1.89E-5 SWF1 & branched chain AA biosynthesis 25 2.61E-5
17 SGTC_134 0269-0018 4.01 6.9 µM 2.18E-5 131 3.00E-5
18 SGTC_2302 7771753 3.95 200.0 µM 2.83E-5 43 3.85E-5
19 SGTC_2999 9069765 3.88 71.4 µM 3.82E-5 amide catabolism 28 5.14E-5
20 SGTC_10 0279-0212 3.85 42.6 µM 4.36E-5 TRP & mitochondrial translation 131 5.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.63E-33 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.188 5.34E-28 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.186 1.28E-27 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.186 2.00E-27 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.182 1.87E-26 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.180 5.53E-26 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.180 6.39E-26 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.177 4.23E-25 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.175 1.51E-24 YMR064W AEP1 hom Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
0.171 1.64E-23 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.170 3.15E-23 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.169 5.40E-23 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.167 2.01E-22 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.166 4.42E-22 YDR322W MRPL35 hom Mitochondrial ribosomal protein of the large subunit
0.163 2.53E-21 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis