YOL011W / PLB3

Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL011W / PLB3

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.09|P-value:7.13E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.34|P-value:2.04E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.36|P-value:2.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:2.97|P-value:8.28E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.00|P-value:7.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.91|P-value:2.60E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:3.16|P-value:4.18E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.98|P-value:1.31E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.23|P-value:4.29E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-4.04|P-value:1.47E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-4.20|P-value:6.95E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.60|P-value:9.51E-7 ID:SGTC_847|Compound:0342-0274|FD-Score:3.65|P-value:5.70E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.55|P-value:8.87E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:1.12E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.40|P-value:2.27E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.15|P-value:4.21E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.30|P-value:2.92E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.91|P-value:1.79E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:3.17E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.02|P-value:6.92E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_1641|Compound:st009299|FD-Score:2.95|P-value:8.91E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:9.24E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.78|P-value:3.31E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.13|P-value:6.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.31|P-value:3.24E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.41|P-value:2.17E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.79|P-value:3.10E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.74|P-value:3.93E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.23|P-value:3.12E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.70|P-value:6.67E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.12|P-value:3.54E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.57|P-value:1.15E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:9.28E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.49|P-value:1.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.32|P-value:2.57E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.58|P-value:7.87E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.79|P-value:2.28E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.63|P-value:9.01E-5 ID:SGTC_3210|Compound:9128157|FD-Score:5.89|P-value:2.87E-10 ID:SGTC_3297|Compound:9117502|FD-Score:3.90|P-value:1.88E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.09|P-value:7.13E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.34|P-value:2.04E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.36|P-value:2.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:2.97|P-value:8.28E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.00|P-value:7.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.91|P-value:2.60E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:3.16|P-value:4.18E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.98|P-value:1.31E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.23|P-value:4.29E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:-4.04|P-value:1.47E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-4.20|P-value:6.95E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.60|P-value:9.51E-7 ID:SGTC_847|Compound:0342-0274|FD-Score:3.65|P-value:5.70E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.55|P-value:8.87E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:1.12E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.40|P-value:2.27E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.15|P-value:4.21E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.30|P-value:2.92E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.91|P-value:1.79E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.79|P-value:3.17E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.02|P-value:6.92E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.20|P-value:4.86E-4 ID:SGTC_1641|Compound:st009299|FD-Score:2.95|P-value:8.91E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:9.24E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.78|P-value:3.31E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.13|P-value:6.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.31|P-value:3.24E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.41|P-value:2.17E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.79|P-value:3.10E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.74|P-value:3.93E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.23|P-value:3.12E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.70|P-value:6.67E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.12|P-value:3.54E-8 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.45|P-value:1.32E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.57|P-value:1.15E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:9.28E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.49|P-value:1.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.32|P-value:2.57E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.58|P-value:7.87E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.79|P-value:2.28E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.36|P-value:2.59E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.63|P-value:9.01E-5 ID:SGTC_3210|Compound:9128157|FD-Score:5.89|P-value:2.87E-10 ID:SGTC_3297|Compound:9117502|FD-Score:3.90|P-value:1.88E-5

Top fitness defect scores for YOL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 5.89 49.5 µM 2.87E-10 16 1.92E-9
2 SGTC_2606 farnesol 5.12 9.8 µM 3.54E-8 6 1.55E-7
3 SGTC_2754 granisetron 4.79 64.0 µM 2.28E-7 19 8.47E-7
4 SGTC_2693 st077581 4.32 40.7 µM 2.57E-6 24 7.73E-6
5 SGTC_1186 1319-0216 4.30 26.0 µM 2.92E-6 13 8.68E-6
6 SGTC_1892 st058411 4.06 7.4 µM 9.24E-6 18 2.48E-5
7 SGTC_361 000s-0510 3.98 1.4 µM 1.31E-5 31 3.39E-5
8 SGTC_1309 pyrazolanthrone 3.91 13.4 µM 1.79E-5 22 4.52E-5
9 SGTC_3297 9117502 3.90 71.4 µM 1.88E-5 9 4.73E-5
10 SGTC_2309 7664088 3.79 163.9 µM 3.10E-5 38 7.47E-5
11 SGTC_1370 2001-0092 3.79 44.6 µM 3.17E-5 45 7.63E-5
12 SGTC_1924 st058459 3.78 75.1 µM 3.31E-5 15 7.92E-5
13 SGTC_2318 6029776 3.74 164.0 µM 3.93E-5 35 9.27E-5
14 SGTC_847 0342-0274 3.65 5.5 µM 5.70E-5 25 1.30E-4
15 SGTC_2736 butenafine 3.58 14.7 µM 7.87E-5 40 1.74E-4
16 SGTC_851 0394-0702 3.55 453.0 µM 8.87E-5 mitochondrial processes 22 1.95E-4
17 SGTC_1051 3253-3903 3.53 78.0 µM 9.36E-5 36 2.04E-4
18 SGTC_2692 st077426 3.49 47.7 µM 1.11E-4 31 2.38E-4
19 SGTC_1050 3232-1156 3.49 69.3 µM 1.12E-4 RSC complex & mRNA processing 37 2.41E-4
20 SGTC_2608 thymoquinone 3.45 42.7 µM 1.32E-4 30 2.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 3.08E-15 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.133 1.16E-14 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.122 1.21E-12 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.118 7.20E-12 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.115 2.02E-11 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.115 2.27E-11 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.113 5.01E-11 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.105 8.97E-10 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.104 1.43E-9 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.102 2.85E-9 YHR077C NMD2 hom Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
0.102 3.87E-9 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.100 6.50E-9 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.099 1.04E-8 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.097 1.94E-8 YER085C_p YER085C_p hom Putative protein of unknown function
0.096 2.51E-8 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress