YOL013W-A_p

Putative protein of unknown function; identified by SAGE

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL013W-A / YOL013W-A

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:5.27|P-value:3.42E-8 ID:SGTC_95|Compound:0471-0001|FD-Score:5.01|P-value:1.49E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:3.44|P-value:2.16E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.83|P-value:4.44E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:4.93|P-value:2.30E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:3.36|P-value:3.00E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.79|P-value:4.89E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.70|P-value:7.73E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.10|P-value:7.03E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.31|P-value:5.11E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.25|P-value:4.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.71|P-value:2.62E-9 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.20|P-value:5.04E-8 ID:SGTC_1629|Compound:st005085|FD-Score:3.69|P-value:8.04E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.12|P-value:7.29E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.18|P-value:5.14E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.79|P-value:5.43E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.94|P-value:2.82E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.78|P-value:4.86E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.73|P-value:6.39E-7 ID:SGTC_1937|Compound:st074714|FD-Score:4.92|P-value:2.36E-7 ID:SGTC_2092|Compound:5303694|FD-Score:3.13|P-value:7.02E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.32|P-value:3.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.28|P-value:3.57E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.53|P-value:1.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.39|P-value:2.34E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.74|P-value:5.89E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.04|P-value:9.52E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.17|P-value:5.97E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-4.12|P-value:1.12E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:3.75E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-4.18|P-value:8.34E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-6.76|P-value:1.82E-12 ID:SGTC_3259|Compound:9138485|FD-Score:-3.23|P-value:4.28E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.56|P-value:1.20E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:5.27|P-value:3.42E-8 ID:SGTC_95|Compound:0471-0001|FD-Score:5.01|P-value:1.49E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:3.44|P-value:2.16E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.83|P-value:4.44E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:4.93|P-value:2.30E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:3.36|P-value:3.00E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:4.79|P-value:4.89E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.70|P-value:7.73E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.10|P-value:7.03E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.31|P-value:5.11E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:2.95E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.25|P-value:4.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.71|P-value:2.62E-9 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.20|P-value:5.04E-8 ID:SGTC_1629|Compound:st005085|FD-Score:3.69|P-value:8.04E-5 ID:SGTC_1699|Compound:st031318|FD-Score:3.12|P-value:7.29E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.18|P-value:5.14E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.79|P-value:5.43E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.94|P-value:2.82E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.78|P-value:4.86E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.73|P-value:6.39E-7 ID:SGTC_1937|Compound:st074714|FD-Score:4.92|P-value:2.36E-7 ID:SGTC_2092|Compound:5303694|FD-Score:3.13|P-value:7.02E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.32|P-value:3.43E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.28|P-value:3.57E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.50|P-value:1.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.53|P-value:1.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.39|P-value:2.34E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.74|P-value:5.89E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.04|P-value:9.52E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.17|P-value:5.97E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-4.12|P-value:1.12E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:3.75E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-4.18|P-value:8.34E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.63|P-value:1.11E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-6.76|P-value:1.82E-12 ID:SGTC_3259|Compound:9138485|FD-Score:-3.23|P-value:4.28E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.56|P-value:1.20E-4

Top fitness defect scores for YOL013W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1265 0819-1001 5.71 68.8 µM 2.62E-9 4 5.81E-9
2 SGTC_94 0334-0113 5.27 514.8 µM 3.42E-8 6 6.72E-8
3 SGTC_1512 0259-0544 5.20 12.2 µM 5.04E-8 5 9.73E-8
4 SGTC_95 0471-0001 5.01 561.1 µM 1.49E-7 9 2.73E-7
5 SGTC_320 4092-0846 4.93 5.3 µM 2.30E-7 ergosterol depletion effects on membrane 25 4.14E-7
6 SGTC_1937 st074714 4.92 47.2 µM 2.36E-7 23 4.24E-7
7 SGTC_870 0573-2213 4.79 57.6 µM 4.89E-7 ERG2 7 8.51E-7
8 SGTC_1933 st074711 4.73 15.9 µM 6.39E-7 24 1.10E-6
9 SGTC_3137 9097352 4.63 49.5 µM 1.11E-6 21 1.86E-6
10 SGTC_1122 capsaicin 4.31 818.6 nM 5.11E-6 19 7.99E-6
11 SGTC_1859 st055998 3.94 20.0 µM 2.82E-5 23 4.07E-5
12 SGTC_316 k060-0003 3.83 58.6 µM 4.44E-5 18 6.30E-5
13 SGTC_1854 st056233 3.79 32.9 µM 5.43E-5 amide catabolism 24 7.63E-5
14 SGTC_1103 duloxetine 3.70 36.1 µM 7.73E-5 39 1.07E-4
15 SGTC_1629 st005085 3.69 44.9 µM 8.04E-5 RPP1 & pyrimidine depletion 45 1.11E-4
16 SGTC_1477 0139-0234 3.63 16.0 µM 1.04E-4 13 1.42E-4
17 SGTC_2938 9059746 3.50 27.3 µM 1.72E-4 fatty acid desaturase (OLE1) 54 2.29E-4
18 SGTC_2561 acetosyringone 3.50 100.0 µM 1.75E-4 43 2.34E-4
19 SGTC_101 0490-5701 3.44 117.5 µM 2.16E-4 30 2.86E-4
20 SGTC_2868 9035608 3.37 32.5 µM 2.92E-4 36 3.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 9.23E-8 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.091 1.26E-7 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.090 1.74E-7 YBR019C GAL10 hom UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
0.090 1.86E-7 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.083 1.50E-6 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.082 1.82E-6 YOL112W MSB4 hom GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
0.077 8.08E-6 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.076 1.08E-5 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.075 1.30E-5 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
0.074 1.70E-5 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.074 1.73E-5 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.073 2.09E-5 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.073 2.38E-5 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.073 2.49E-5 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.072 2.90E-5 YPR117W_p YPR117W_p hom Putative protein of unknown function