YOL015W / IRC10

Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL015W / IRC10

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.77|P-value:3.12E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.10|P-value:1.00E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.60|P-value:5.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.46|P-value:8.58E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.86|P-value:2.24E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-4.26|P-value:5.55E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.53|P-value:1.96E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:4.13|P-value:8.79E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.54|P-value:6.55E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.97|P-value:1.55E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.57|P-value:5.89E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.42|P-value:4.09E-7 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.40|P-value:3.20E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.96|P-value:1.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.87|P-value:2.26E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.36|P-value:5.67E-7 ID:SGTC_2443|Compound:5493264|FD-Score:-3.69|P-value:4.07E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.50|P-value:2.94E-7 ID:SGTC_2893|Compound:9048488|FD-Score:4.39|P-value:3.35E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.49|P-value:7.42E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.89|P-value:2.07E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.60|P-value:5.35E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.55|P-value:6.32E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.42|P-value:9.32E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.77|P-value:3.12E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.10|P-value:1.00E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.60|P-value:5.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.46|P-value:8.58E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.86|P-value:2.24E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-4.26|P-value:5.55E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.53|P-value:1.96E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:4.13|P-value:8.79E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.54|P-value:6.55E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.97|P-value:1.55E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.57|P-value:5.89E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.42|P-value:4.09E-7 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.40|P-value:3.20E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.96|P-value:1.64E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.87|P-value:2.26E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.36|P-value:5.67E-7 ID:SGTC_2443|Compound:5493264|FD-Score:-3.69|P-value:4.07E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.50|P-value:2.94E-7 ID:SGTC_2893|Compound:9048488|FD-Score:4.39|P-value:3.35E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.49|P-value:7.42E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.89|P-value:2.07E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.60|P-value:5.35E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.55|P-value:6.32E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.42|P-value:9.32E-4

Top fitness defect scores for YOL015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1110 3-hydroxy-3'-methoxyflavone 5.42 1.2 µM 4.09E-7 iron homeostasis 20 2.90E-8
2 SGTC_2893 9048488 4.39 26.0 µM 3.35E-5 fatty acid desaturase (OLE1) 16 5.79E-6
3 SGTC_693 4161-2696 4.13 114.0 µM 8.79E-5 7 1.84E-5
4 SGTC_764 1951-2361 3.97 146.0 µM 1.55E-4 36 3.63E-5
5 SGTC_224 benfluorex 3.86 43.9 µM 2.24E-4 6 5.65E-5
6 SGTC_3067 9117431 3.60 49.5 µM 5.35E-4 22 1.61E-4
7 SGTC_3078 9116413 3.55 49.5 µM 6.32E-4 unfolded protein response 49 1.96E-4
8 SGTC_2900 5328528 3.49 85.3 µM 7.42E-4 Golgi 45 2.37E-4
9 SGTC_3316 9136639 3.42 10.6 µM 9.32E-4 29 3.11E-4
10 SGTC_1797 st048695 3.39 56.8 µM 0.00103 NEO1 90 3.52E-4
11 SGTC_1233 0325-0408 3.38 14.2 µM 0.00107 41 3.67E-4
12 SGTC_3011 9081274 3.27 71.4 µM 0.00147 40 5.36E-4
13 SGTC_2850 9015429 3.25 58.4 µM 0.00155 34 5.74E-4
14 SGTC_2587 piperic acid 3.25 92.2 µM 0.00156 45 5.75E-4
15 SGTC_694 1315-0438 3.25 43.2 µM 0.00158 31 5.85E-4
16 SGTC_2810 7959871 3.24 45.5 µM 0.00160 copper-dependent oxidative stress 73 5.92E-4
17 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.23 61.8 µM 0.00166 ergosterol biosynthesis 30 6.20E-4
18 SGTC_46 0329-0187a 3.23 2.2 µM 0.00166 110 6.23E-4
19 SGTC_1024 4507-0395 3.19 26.0 µM 0.00187 TSC3-RPN4 55 7.17E-4
20 SGTC_2883 9059145 3.19 45.5 µM 0.00188 27 7.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.72E-14 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 1.79E-12 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.119 4.12E-12 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.117 1.20E-11 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.113 5.26E-11 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.110 1.86E-10 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.104 1.80E-9 YDR514C YDR514C hom Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
0.103 2.19E-9 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.099 7.92E-9 YCR014C POL4 hom DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
0.099 1.07E-8 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.098 1.55E-8 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.097 1.82E-8 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.096 2.59E-8 YPR152C URN1 hom Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.095 3.64E-8 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.092 8.62E-8 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA