YOL017W / ESC8

Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL017W / ESC8

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:-3.00|P-value:7.20E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.37|P-value:3.33E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.07|P-value:8.21E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.86|P-value:3.46E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:3.78|P-value:5.02E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.32|P-value:3.22E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.22|P-value:4.77E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.05|P-value:1.50E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.81|P-value:4.37E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.96|P-value:2.28E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.38|P-value:3.15E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.68|P-value:7.67E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.21|P-value:4.95E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.43|P-value:2.42E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.44|P-value:2.00E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_1748|Compound:st037455|FD-Score:5.91|P-value:4.77E-10 ID:SGTC_1749|Compound:st037932|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.23|P-value:4.63E-4 ID:SGTC_1831|Compound:st055328|FD-Score:5.62|P-value:3.06E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-3.41|P-value:1.51E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.94|P-value:9.09E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.03|P-value:6.67E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.26|P-value:2.75E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.35|P-value:1.96E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.97|P-value:3.36E-10 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.67|P-value:8.09E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_2879|Compound:9041815|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.44|P-value:9.35E-9 ID:SGTC_2938|Compound:9059746|FD-Score:3.44|P-value:2.07E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.22|P-value:4.65E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.99|P-value:1.94E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.00|P-value:7.20E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.37|P-value:3.33E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.07|P-value:8.21E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.86|P-value:3.46E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:3.78|P-value:5.02E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.32|P-value:3.22E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.22|P-value:4.77E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:4.05|P-value:1.50E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.81|P-value:4.37E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.96|P-value:2.28E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.38|P-value:3.15E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.68|P-value:7.67E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.21|P-value:4.95E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.43|P-value:2.42E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.44|P-value:2.00E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_1748|Compound:st037455|FD-Score:5.91|P-value:4.77E-10 ID:SGTC_1749|Compound:st037932|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.23|P-value:4.63E-4 ID:SGTC_1831|Compound:st055328|FD-Score:5.62|P-value:3.06E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-3.41|P-value:1.51E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.94|P-value:9.09E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.03|P-value:6.67E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.26|P-value:2.75E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.35|P-value:1.96E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.97|P-value:3.36E-10 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.67|P-value:8.09E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_2879|Compound:9041815|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.44|P-value:9.35E-9 ID:SGTC_2938|Compound:9059746|FD-Score:3.44|P-value:2.07E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.22|P-value:4.65E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.99|P-value:1.94E-5

Top fitness defect scores for YOL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 5.97 64.0 µM 3.36E-10 sphingolipid biosynthesis & PDR1 18 1.20E-9
2 SGTC_1748 st037455 5.91 53.6 µM 4.77E-10 6 1.67E-9
3 SGTC_1831 st055328 5.62 12.0 µM 3.06E-9 heme biosynthesis & mitochondrial translocase 7 9.37E-9
4 SGTC_2932 9016711 5.44 44.5 µM 9.35E-9 18 2.65E-8
5 SGTC_1423 4048-0112 4.43 5.6 µM 2.42E-6 18 4.65E-6
6 SGTC_1229 0139-0193 4.38 12.2 µM 3.15E-6 RSC complex & mRNA processing 3 5.94E-6
7 SGTC_319 1348-1596 4.37 45.5 µM 3.33E-6 RSC & ERG11 14 6.26E-6
8 SGTC_876 0720-0963 4.05 56.8 µM 1.50E-5 13 2.55E-5
9 SGTC_3327 9140648 3.99 26.9 µM 1.94E-5 10 3.24E-5
10 SGTC_1204 4049-0315 3.96 18.3 µM 2.28E-5 27 3.76E-5
11 SGTC_2791 5663188 3.91 71.4 µM 2.87E-5 RPP1 & pyrimidine depletion 20 4.67E-5
12 SGTC_2689 tacrolimus 3.90 100.0 µM 2.96E-5 47 4.81E-5
13 SGTC_569 4130-2812 3.86 160.0 µM 3.46E-5 amide catabolism 7 5.56E-5
14 SGTC_1106 tegaserod maleate 3.81 11.7 µM 4.37E-5 23 6.92E-5
15 SGTC_694 1315-0438 3.78 43.2 µM 5.02E-5 12 7.87E-5
16 SGTC_1380 2291-0730 3.68 164.0 µM 7.67E-5 33 1.17E-4
17 SGTC_2697 mebhydrolin 3.67 72.4 µM 8.09E-5 NEO1 81 1.23E-4
18 SGTC_2879 9041815 3.45 71.4 µM 1.99E-4 3 2.85E-4
19 SGTC_1482 3346-2049 3.44 8.5 µM 2.00E-4 42 2.86E-4
20 SGTC_2057 5236571 3.44 38.3 µM 2.01E-4 RPP1 & pyrimidine depletion 52 2.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.73E-17 YOL106W_d YOL106W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.139 6.68E-16 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.111 1.21E-10 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.105 9.10E-10 YLR286C CTS1 hom Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
0.098 1.38E-8 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.097 1.71E-8 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.094 5.31E-8 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.093 6.06E-8 YNL190W_p YNL190W_p hom Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site
0.090 1.62E-7 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy
0.089 2.16E-7 YMR087W YMR087W hom Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
0.089 2.65E-7 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.084 9.71E-7 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.084 1.05E-6 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.083 1.53E-6 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.080 3.29E-6 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.