YOL019W_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL019W / YOL019W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.16|P-value:5.01E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.87|P-value:1.70E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.61|P-value:3.74E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.77|P-value:4.27E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.01|P-value:8.77E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:5.02|P-value:1.38E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.83|P-value:1.99E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.47|P-value:5.95E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.38|P-value:7.94E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.93|P-value:1.60E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.90|P-value:1.55E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.58|P-value:4.04E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-5.75|P-value:4.97E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.42|P-value:1.86E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.68|P-value:2.92E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.98|P-value:1.00E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.45|P-value:7.06E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.66|P-value:3.53E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.78|P-value:2.38E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.78|P-value:4.05E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.22|P-value:3.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.26|P-value:3.48E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.41|P-value:7.11E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.37|P-value:9.30E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.73|P-value:2.83E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.60|P-value:4.37E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.46|P-value:1.53E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.62|P-value:3.52E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.37|P-value:2.22E-5 ID:SGTC_3188|Compound:9110789|FD-Score:3.49|P-value:5.54E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.55|P-value:4.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.07|P-value:7.22E-5 ID:SGTC_3304|Compound:9125678|FD-Score:5.16|P-value:7.19E-7 ID:SGTC_3337|Compound:9144342|FD-Score:3.83|P-value:1.71E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.88|P-value:2.54E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:4.16|P-value:5.01E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.87|P-value:1.70E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.61|P-value:3.74E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:4.77|P-value:4.27E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.01|P-value:8.77E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:5.02|P-value:1.38E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.83|P-value:1.99E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.47|P-value:5.95E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.38|P-value:7.94E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.93|P-value:1.60E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.90|P-value:1.55E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.58|P-value:4.04E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-5.75|P-value:4.97E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.78|P-value:2.06E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.42|P-value:1.86E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.68|P-value:2.92E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.98|P-value:1.00E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.45|P-value:7.06E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.66|P-value:3.53E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.98|P-value:1.01E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-3.78|P-value:2.38E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.78|P-value:4.05E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.22|P-value:3.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.26|P-value:3.48E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.41|P-value:7.11E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.37|P-value:9.30E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.73|P-value:2.83E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.60|P-value:4.37E-4 ID:SGTC_2868|Compound:9035608|FD-Score:4.46|P-value:1.53E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.62|P-value:3.52E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.37|P-value:2.22E-5 ID:SGTC_3188|Compound:9110789|FD-Score:3.49|P-value:5.54E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.55|P-value:4.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.07|P-value:7.22E-5 ID:SGTC_3304|Compound:9125678|FD-Score:5.16|P-value:7.19E-7 ID:SGTC_3337|Compound:9144342|FD-Score:3.83|P-value:1.71E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.88|P-value:2.54E-6

Top fitness defect scores for YOL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_965 1291-5240 5.93 308.0 µM 1.60E-8 6 1.55E-9
2 SGTC_3304 9125678 5.16 46.1 µM 7.19E-7 20 1.22E-7
3 SGTC_543 3844-1095 5.02 191.0 µM 1.38E-6 ERG2 27 2.58E-7
4 SGTC_3345 9148410 4.88 3.6 µM 2.54E-6 3 5.18E-7
5 SGTC_2537 larixol 4.78 68.9 µM 4.05E-6 10 8.82E-7
6 SGTC_348 k064-0012 4.77 10.7 µM 4.27E-6 60S ribosome export 7 9.38E-7
7 SGTC_2868 9035608 4.46 32.5 µM 1.53E-5 8 4.04E-6
8 SGTC_1878 temozolomide 4.42 1.0 mM 1.86E-5 4 5.04E-6
9 SGTC_3091 9116372 4.37 49.5 µM 2.22E-5 9 6.18E-6
10 SGTC_2601 securinine 4.26 100.0 µM 3.48E-5 25 1.04E-5
11 SGTC_2583 asiatic acid 4.22 100.0 µM 3.98E-5 31 1.21E-5
12 SGTC_18 0111-0177 4.16 500.0 nM 5.01E-5 63 1.57E-5
13 SGTC_3274 9138298 4.07 49.5 µM 7.22E-5 18 2.39E-5
14 SGTC_392 N-ethylmaleimide 4.01 8.3 µM 8.77E-5 RNA pol III & RNase P/MRP 12 2.98E-5
15 SGTC_2188 6126565 3.98 140.7 µM 1.00E-4 mitochondrial processes 14 3.47E-5
16 SGTC_2470 5664817 3.98 21.7 µM 1.01E-4 9 3.51E-5
17 SGTC_3337 9144342 3.83 33.5 µM 1.71E-4 30 6.40E-5
18 SGTC_1874 staurosporine 3.78 7.6 µM 2.06E-4 cell wall signaling 32 7.90E-5
19 SGTC_2099 5377090 3.68 177.4 µM 2.92E-4 30 1.17E-4
20 SGTC_3004 9076122 3.62 71.4 µM 3.52E-4 21 1.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.82E-14 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.129 5.93E-14 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.128 9.76E-14 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.121 2.07E-12 YFL004W VTC2 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.111 1.35E-10 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.095 3.18E-8 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.084 1.23E-6 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.083 1.49E-6 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.081 2.65E-6 YFL047W RGD2 hom GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.077 8.75E-6 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.073 2.15E-5 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.073 2.12E-5 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.073 2.21E-5 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication
0.071 4.29E-5 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.070 4.91E-5 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif