YOL020W / TAT2

High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL020W / TAT2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.42|P-value:5.90E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.23|P-value:9.16E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.76|P-value:1.81E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.45|P-value:1.18E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.28|P-value:9.37E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.79|P-value:1.33E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.19|P-value:3.45E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:5.64|P-value:4.15E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:3.76|P-value:1.79E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.08|P-value:5.44E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:4.04|P-value:6.24E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.40|P-value:1.48E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.11|P-value:4.79E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.32|P-value:6.76E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.66|P-value:2.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.43|P-value:5.68E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.55|P-value:3.13E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.37|P-value:5.70E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.81|P-value:1.49E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.46|P-value:1.14E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.60|P-value:3.23E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.70|P-value:3.95E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.12|P-value:5.79E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.91|P-value:1.57E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.69|P-value:2.34E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.60|P-value:3.18E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.09|P-value:4.05E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.38|P-value:5.53E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.10|P-value:4.91E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.23|P-value:2.97E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.52|P-value:3.47E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.30|P-value:8.81E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.48|P-value:4.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.13|P-value:3.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.56|P-value:3.06E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.18|P-value:3.63E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.16|P-value:3.91E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-8.05|P-value:5.66E-15 ID:SGTC_2054|Compound:5233173|FD-Score:5.01|P-value:9.62E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.54|P-value:6.30E-6 ID:SGTC_2261|Compound:9010538|FD-Score:3.31|P-value:8.52E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.60|P-value:6.17E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-4.38|P-value:1.23E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.39|P-value:6.57E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.35|P-value:7.57E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.93|P-value:9.79E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-5.01|P-value:7.38E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:4.28|P-value:2.40E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.56|P-value:3.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.38|P-value:5.68E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.73|P-value:1.62E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.48|P-value:4.81E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.36|P-value:5.98E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.28|P-value:2.65E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.37|P-value:7.06E-4 ID:SGTC_2952|Compound:9073731|FD-Score:5.07|P-value:7.31E-7 ID:SGTC_3082|Compound:9117008|FD-Score:4.27|P-value:2.57E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.53|P-value:4.14E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.46|P-value:1.12E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:2.28E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.77|P-value:2.92E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.37|P-value:5.79E-4 ID:SGTC_3271|Compound:9137798|FD-Score:4.29|P-value:2.36E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.43|P-value:4.70E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.93|P-value:9.80E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.42|P-value:5.90E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.23|P-value:9.16E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.76|P-value:1.81E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.45|P-value:1.18E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.28|P-value:9.37E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.79|P-value:1.33E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.19|P-value:3.45E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:5.64|P-value:4.15E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:3.76|P-value:1.79E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.08|P-value:5.44E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:4.04|P-value:6.24E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:4.40|P-value:1.48E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.11|P-value:4.79E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.32|P-value:6.76E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.66|P-value:2.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.43|P-value:5.68E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.55|P-value:3.13E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.37|P-value:5.70E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.81|P-value:1.49E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.46|P-value:1.14E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.36|P-value:1.74E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.60|P-value:3.23E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.70|P-value:3.95E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.12|P-value:5.79E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.91|P-value:1.57E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.69|P-value:2.34E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.60|P-value:3.18E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-4.09|P-value:4.05E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.38|P-value:5.53E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:4.10|P-value:4.91E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.23|P-value:2.97E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.52|P-value:3.47E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.30|P-value:8.81E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.48|P-value:4.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.13|P-value:3.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.56|P-value:3.06E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.39|P-value:6.68E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.18|P-value:3.63E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.16|P-value:3.91E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-8.05|P-value:5.66E-15 ID:SGTC_2054|Compound:5233173|FD-Score:5.01|P-value:9.62E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.54|P-value:6.30E-6 ID:SGTC_2261|Compound:9010538|FD-Score:3.31|P-value:8.52E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.49|P-value:1.02E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.60|P-value:6.17E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-4.38|P-value:1.23E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.39|P-value:6.57E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.35|P-value:7.57E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.93|P-value:9.79E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-5.01|P-value:7.38E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:4.28|P-value:2.40E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.56|P-value:3.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.38|P-value:5.68E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.73|P-value:1.62E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.48|P-value:4.81E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.36|P-value:5.98E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.28|P-value:2.65E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.37|P-value:7.06E-4 ID:SGTC_2952|Compound:9073731|FD-Score:5.07|P-value:7.31E-7 ID:SGTC_3082|Compound:9117008|FD-Score:4.27|P-value:2.57E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.53|P-value:4.14E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.46|P-value:1.12E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.64|P-value:2.28E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.77|P-value:2.92E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.37|P-value:5.79E-4 ID:SGTC_3271|Compound:9137798|FD-Score:4.29|P-value:2.36E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.43|P-value:4.70E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.93|P-value:9.80E-5

Top fitness defect scores for YOL020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_704 1310-0270 5.64 142.0 µM 4.15E-8 9 8.64E-9
2 SGTC_2908 7930301 5.28 100.0 µM 2.65E-7 7 6.60E-8
3 SGTC_1221 2958-7315 5.12 257.0 µM 5.79E-7 5 1.56E-7
4 SGTC_2952 9073731 5.07 13.8 µM 7.31E-7 tubulin folding & SWR complex 13 2.01E-7
5 SGTC_2054 5233173 5.01 129.0 µM 9.62E-7 mitochondrial response to ROS 26 2.71E-7
6 SGTC_1255 0566-0045 4.91 221.0 µM 1.57E-6 excess fatty acid 12 4.66E-7
7 SGTC_3225 9130819 4.77 49.5 µM 2.92E-6 amide catabolism 12 9.19E-7
8 SGTC_1196 1588-0294 4.70 184.0 µM 3.95E-6 6 1.28E-6
9 SGTC_2352 9027995 4.60 87.8 µM 6.17E-6 tubulin folding & SWR complex 23 2.09E-6
10 SGTC_2302 7771753 4.49 200.0 µM 1.02E-5 29 3.62E-6
11 SGTC_1262 0737-0114 4.49 49.6 µM 1.02E-5 10 3.63E-6
12 SGTC_3210 9128157 4.46 49.5 µM 1.12E-5 35 4.02E-6
13 SGTC_982 1491-0518 4.46 27.5 µM 1.14E-5 6 4.09E-6
14 SGTC_163 1327-0036 4.45 7.5 µM 1.18E-5 83 4.25E-6
15 SGTC_849 0386-0493 4.40 241.0 µM 1.48E-5 9 5.44E-6
16 SGTC_1096 rimcazole 4.36 32.2 µM 1.74E-5 2 6.52E-6
17 SGTC_3271 9137798 4.29 49.5 µM 2.36E-5 3 9.09E-6
18 SGTC_2521 angolensin 4.28 13.4 µM 2.40E-5 8 9.25E-6
19 SGTC_3082 9117008 4.27 49.5 µM 2.57E-5 12 9.96E-6
20 SGTC_1378 2093-0007 4.23 380.0 nM 2.97E-5 17 1.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.34E-11 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.084 9.66E-7 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.084 1.09E-6 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.081 2.99E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.077 8.98E-6 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.074 2.02E-5 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.073 2.06E-5 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.072 3.37E-5 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.071 3.64E-5 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.071 4.31E-5 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.069 5.82E-5 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.069 7.41E-5 YFL010C WWM1 hom WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
0.069 7.15E-5 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.068 8.33E-5 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.067 1.03E-4 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression