YOL023W / IFM1

Mitochondrial translation initiation factor 2

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL023W / IFM1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:6.16|P-value:1.15E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:3.67|P-value:4.50E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.26|P-value:5.57E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.28|P-value:8.29E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.62|P-value:5.29E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.70|P-value:4.05E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.72|P-value:3.35E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.23|P-value:1.04E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.97|P-value:3.28E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:5.25|P-value:9.73E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:6.74|P-value:4.94E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:-5.04|P-value:2.11E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.96|P-value:1.50E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.45|P-value:8.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.78|P-value:3.07E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.56|P-value:6.41E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:3.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:6.55|P-value:1.39E-9 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.81|P-value:2.81E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.08|P-value:1.08E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.53|P-value:6.22E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:6.47|P-value:2.16E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.49|P-value:7.88E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.41|P-value:3.19E-5 ID:SGTC_1571|Compound:st070080|FD-Score:5.49|P-value:3.21E-7 ID:SGTC_1607|Compound:st000305|FD-Score:-3.63|P-value:4.56E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.58|P-value:5.92E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.80|P-value:2.90E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.49|P-value:2.38E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.24|P-value:6.09E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.50|P-value:7.67E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.33|P-value:6.80E-7 ID:SGTC_1956|Compound:st077085|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.55|P-value:6.52E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.14|P-value:8.81E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.99|P-value:1.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.53|P-value:2.05E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.75|P-value:3.45E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.99|P-value:1.53E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.55|P-value:5.80E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.43|P-value:2.95E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.78|P-value:3.12E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.75|P-value:3.08E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.60|P-value:5.65E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.52|P-value:7.29E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.59|P-value:1.38E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.15|P-value:8.52E-5 ID:SGTC_2984|Compound:9022109|FD-Score:3.63|P-value:5.14E-4 ID:SGTC_3013|Compound:9080133|FD-Score:8.14|P-value:7.42E-14 ID:SGTC_3087|Compound:9117406|FD-Score:-3.39|P-value:9.72E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.60|P-value:5.52E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.48|P-value:2.44E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.68|P-value:4.31E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.55|P-value:6.49E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:6.16|P-value:1.15E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:3.67|P-value:4.50E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.26|P-value:5.57E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.28|P-value:8.29E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.62|P-value:5.29E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.70|P-value:4.05E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.72|P-value:3.35E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.23|P-value:1.04E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:4.97|P-value:3.28E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:5.25|P-value:9.73E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:6.74|P-value:4.94E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:-5.04|P-value:2.11E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.96|P-value:1.50E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.45|P-value:8.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.78|P-value:3.07E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.56|P-value:6.41E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:3.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:6.55|P-value:1.39E-9 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.81|P-value:2.81E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.08|P-value:1.08E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.53|P-value:6.22E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:6.47|P-value:2.16E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.49|P-value:7.88E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.41|P-value:3.19E-5 ID:SGTC_1571|Compound:st070080|FD-Score:5.49|P-value:3.21E-7 ID:SGTC_1607|Compound:st000305|FD-Score:-3.63|P-value:4.56E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.58|P-value:5.92E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.80|P-value:2.90E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.49|P-value:2.38E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.24|P-value:6.09E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.50|P-value:7.67E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.33|P-value:6.80E-7 ID:SGTC_1956|Compound:st077085|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.77|P-value:3.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.55|P-value:6.52E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.14|P-value:8.81E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.99|P-value:1.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.53|P-value:2.05E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.75|P-value:3.45E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.99|P-value:1.53E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.55|P-value:5.80E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.43|P-value:2.95E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.78|P-value:3.12E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.75|P-value:3.08E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.60|P-value:5.65E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.52|P-value:7.29E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.59|P-value:1.38E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.15|P-value:8.52E-5 ID:SGTC_2984|Compound:9022109|FD-Score:3.63|P-value:5.14E-4 ID:SGTC_3013|Compound:9080133|FD-Score:8.14|P-value:7.42E-14 ID:SGTC_3087|Compound:9117406|FD-Score:-3.39|P-value:9.72E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.60|P-value:5.52E-4 ID:SGTC_3094|Compound:9117742|FD-Score:4.48|P-value:2.44E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.68|P-value:4.31E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.55|P-value:6.49E-4

Top fitness defect scores for YOL023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3013 9080133 8.14 71.4 µM 7.42E-14 2 1.99E-16
2 SGTC_582 0987-0078 6.74 156.0 µM 4.94E-10 calcium & mitochondrial duress 17 8.19E-12
3 SGTC_1107 amlodipine 6.55 47.0 µM 1.39E-9 2 2.84E-11
4 SGTC_1337 1486-1011 6.47 40.3 µM 2.16E-9 1 4.85E-11
5 SGTC_19 0279-0214 6.16 38.4 µM 1.15E-8 TRP & mitochondrial translation 9 3.64E-10
6 SGTC_1571 st070080 5.49 73.4 µM 3.21E-7 1 2.02E-8
7 SGTC_1911 st060208 5.33 74.3 µM 6.80E-7 10 4.98E-8
8 SGTC_119 0121-0043 5.28 24.8 µM 8.29E-7 mitochondrial stress 44 6.32E-8
9 SGTC_581 0958-0271 5.25 211.0 µM 9.73E-7 22 7.66E-8
10 SGTC_236 1509-0011 5.23 5.3 µM 1.04E-6 315 8.32E-8
11 SGTC_310 1273-0058 4.97 1.1 µM 3.28E-6 mitochondrial stress 184 3.31E-7
12 SGTC_2310 7668677 4.53 200.0 µM 2.05E-5 17 3.01E-6
13 SGTC_1646 st011709 4.49 75.6 µM 2.38E-5 2 3.59E-6
14 SGTC_3094 9117742 4.48 49.5 µM 2.44E-5 10 3.70E-6
15 SGTC_2602 kawain 4.43 100.0 µM 2.95E-5 17 4.66E-6
16 SGTC_1542 7-hydroxy-3'-methoxyflavone 4.41 49.7 µM 3.19E-5 7 5.12E-6
17 SGTC_70 0141-0289 4.26 43.3 µM 5.57E-5 mitochondrial stress 152 1.00E-5
18 SGTC_1755 st041960 4.24 45.2 µM 6.09E-5 18 1.11E-5
19 SGTC_2921 7974240 4.15 10.7 µM 8.52E-5 46 1.67E-5
20 SGTC_2232 chlorophetanol 4.14 41.5 µM 8.81E-5 TRP & mitochondrial translation 114 1.73E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 1.99E-39 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 3.43E-35 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.210 9.75E-35 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.207 6.33E-34 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.206 1.60E-33 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.204 9.54E-33 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.203 1.84E-32 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.199 2.37E-31 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.195 3.16E-30 YHR120W MSH1 hom DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
0.191 1.10E-28 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.189 2.38E-28 YGL143C MRF1 hom Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
0.186 1.59E-27 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.184 6.84E-27 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.183 1.10E-26 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.181 5.20E-26 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules