YOL024W_p

Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL024W / YOL024W

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.63|P-value:6.40E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.03|P-value:6.74E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.16|P-value:5.22E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-5.42|P-value:4.66E-9 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.01|P-value:7.49E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:4.52|P-value:9.07E-7 ID:SGTC_597|Compound:k018-0003|FD-Score:3.24|P-value:3.04E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.19|P-value:3.82E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.15|P-value:5.36E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.02|P-value:6.82E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:7.77E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.64|P-value:5.55E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.39|P-value:1.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.57|P-value:6.39E-7 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.62|P-value:6.41E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-2.97|P-value:8.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.30|P-value:2.29E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.18|P-value:3.73E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.62|P-value:6.41E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-2.91|P-value:9.94E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.06|P-value:5.90E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.09|P-value:5.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.41|P-value:1.48E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.07|P-value:5.67E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.03|P-value:6.91E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.97|P-value:8.49E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.95|P-value:1.38E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.22|P-value:3.31E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.98|P-value:8.36E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.99|P-value:1.24E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-4.71|P-value:2.90E-7 ID:SGTC_3001|Compound:9076041|FD-Score:-3.26|P-value:2.66E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.11|P-value:4.84E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.94|P-value:9.60E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.50|P-value:1.01E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.94|P-value:9.16E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.33|P-value:2.38E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:3.63|P-value:6.40E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.03|P-value:6.74E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.16|P-value:5.22E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-5.42|P-value:4.66E-9 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.01|P-value:7.49E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:4.52|P-value:9.07E-7 ID:SGTC_597|Compound:k018-0003|FD-Score:3.24|P-value:3.04E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.19|P-value:3.82E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.15|P-value:5.36E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.02|P-value:6.82E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:7.77E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.64|P-value:5.55E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.39|P-value:1.69E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.57|P-value:6.39E-7 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.33|P-value:2.20E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.62|P-value:6.41E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-2.97|P-value:8.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.30|P-value:2.29E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.18|P-value:3.73E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.62|P-value:6.41E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-2.91|P-value:9.94E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.06|P-value:5.90E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.09|P-value:5.14E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.41|P-value:1.48E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.07|P-value:5.67E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.03|P-value:6.91E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.97|P-value:8.49E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.95|P-value:1.38E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.22|P-value:3.31E-4 ID:SGTC_2930|Compound:9013230|FD-Score:2.98|P-value:8.36E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.99|P-value:1.24E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-4.71|P-value:2.90E-7 ID:SGTC_3001|Compound:9076041|FD-Score:-3.26|P-value:2.66E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.11|P-value:4.84E-4 ID:SGTC_3130|Compound:9127414|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.94|P-value:9.60E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.50|P-value:1.01E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.94|P-value:9.16E-4 ID:SGTC_3309|Compound:9129340|FD-Score:4.33|P-value:2.38E-6

Top fitness defect scores for YOL024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_550 4123-0385 4.52 25.7 µM 9.07E-7 TSC3-RPN4 15 3.16E-6
2 SGTC_3309 9129340 4.33 25.8 µM 2.38E-6 10 7.50E-6
3 SGTC_2942 9052777 3.99 62.2 µM 1.24E-5 30 3.30E-5
4 SGTC_95 0471-0001 3.63 561.1 µM 6.40E-5 34 1.44E-4
5 SGTC_1266 0828-0227 3.62 32.9 µM 6.41E-5 27 1.45E-4
6 SGTC_1951 sophoraflavanone G 3.62 9.2 µM 6.41E-5 RNA processing & uracil transport 39 1.45E-4
7 SGTC_965 1291-5240 3.54 308.0 µM 9.31E-5 42 2.02E-4
8 SGTC_1262 0737-0114 3.41 49.6 µM 1.60E-4 41 3.30E-4
9 SGTC_1083 didemethylchlorpromazine sulfoxide 3.39 707.4 nM 1.69E-4 redox potentiating 116 3.46E-4
10 SGTC_1241 0364-0022 3.33 50.8 µM 2.20E-4 ERG2 54 4.38E-4
11 SGTC_419 nsc-638432 3.33 893.0 µM 2.20E-4 DNA damage response 32 4.39E-4
12 SGTC_597 k018-0003 3.24 82.8 µM 3.04E-4 RNA pol III & RNase P/MRP 28 5.88E-4
13 SGTC_2917 7979103 3.22 53.8 µM 3.31E-4 65 6.33E-4
14 SGTC_669 0108-0021 3.19 26.2 µM 3.82E-4 fatty acid desaturase (OLE1) 138 7.20E-4
15 SGTC_3130 9127414 3.07 49.5 µM 5.96E-4 36 0.00108
16 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.03 44.4 nM 6.74E-4 DNA damage response 60 0.00120
17 SGTC_2179 6298986 3.03 200.0 µM 6.79E-4 heme requiring 48 0.00121
18 SGTC_2652 actinonin 3.03 100.0 µM 6.91E-4 19 0.00123
19 SGTC_392 N-ethylmaleimide 3.01 8.3 µM 7.49E-4 RNA pol III & RNase P/MRP 43 0.00132
20 SGTC_936 3005-4620 3.00 401.0 µM 7.77E-4 77 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.59E-18 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.136 2.38E-15 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 3.88E-15 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.116 1.66E-11 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.116 1.93E-11 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.108 3.57E-10 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.108 4.23E-10 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.107 5.82E-10 YFL004W VTC2 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.104 1.65E-9 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.102 2.74E-9 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.102 3.52E-9 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.100 5.72E-9 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.099 9.39E-9 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.095 3.31E-8 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.094 4.65E-8 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress