YOL026C / MIM1

Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL026C / MIM1

Click on Significant Values for Screen Details ID:SGTC_258|Compound:haloperidol|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-8.29|P-value:1.20E-17 ID:SGTC_430|Compound:0958-0115|FD-Score:3.21|P-value:4.93E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.90|P-value:3.12E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.16|P-value:6.29E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.29|P-value:3.57E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.18|P-value:5.52E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.84|P-value:4.07E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.51|P-value:1.75E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.05|P-value:8.71E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.12|P-value:1.20E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.10|P-value:7.13E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.10|P-value:7.14E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.03|P-value:9.32E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.01|P-value:1.96E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.17|P-value:5.73E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.12|P-value:7.32E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.17|P-value:5.69E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-4.46|P-value:2.65E-6 ID:SGTC_1813|Compound:st051246|FD-Score:4.34|P-value:4.15E-6 ID:SGTC_1821|Compound:st053465|FD-Score:4.41|P-value:2.97E-6 ID:SGTC_1956|Compound:st077085|FD-Score:-3.50|P-value:1.78E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.68|P-value:8.73E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.67|P-value:8.31E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-3.11|P-value:7.67E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.08|P-value:7.81E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.10|P-value:7.22E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.80|P-value:4.82E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.67|P-value:9.17E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.33|P-value:4.41E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.22|P-value:4.75E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.43|P-value:2.35E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.22|P-value:4.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.21|P-value:7.73E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.02|P-value:9.67E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.05|P-value:9.49E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.45|P-value:2.20E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.82|P-value:4.95E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.61|P-value:1.13E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-4.16|P-value:1.10E-5 ID:SGTC_3229|Compound:9132204|FD-Score:-3.13|P-value:7.04E-4 ID:SGTC_3233|Compound:9132340|FD-Score:6.12|P-value:1.72E-10 ID:SGTC_3246|Compound:9135460|FD-Score:-4.36|P-value:4.31E-6 ID:SGTC_3248|Compound:9135562|FD-Score:-3.07|P-value:8.70E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.01|P-value:9.90E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.30|P-value:3.86E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.08|P-value:7.82E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-8.29|P-value:1.20E-17 ID:SGTC_430|Compound:0958-0115|FD-Score:3.21|P-value:4.93E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.90|P-value:3.12E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.16|P-value:6.29E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.29|P-value:3.57E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.18|P-value:5.52E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.84|P-value:4.07E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.51|P-value:1.75E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.05|P-value:8.71E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.12|P-value:1.20E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.04|P-value:9.85E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.10|P-value:7.13E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.10|P-value:7.14E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.03|P-value:9.32E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.01|P-value:1.96E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.17|P-value:5.73E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.12|P-value:7.32E-4 ID:SGTC_1710|Compound:st031758|FD-Score:3.17|P-value:5.69E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-4.46|P-value:2.65E-6 ID:SGTC_1813|Compound:st051246|FD-Score:4.34|P-value:4.15E-6 ID:SGTC_1821|Compound:st053465|FD-Score:4.41|P-value:2.97E-6 ID:SGTC_1956|Compound:st077085|FD-Score:-3.50|P-value:1.78E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.68|P-value:8.73E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.67|P-value:8.31E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-3.11|P-value:7.67E-4 ID:SGTC_2047|Compound:4141938|FD-Score:3.08|P-value:7.81E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.10|P-value:7.22E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.80|P-value:4.82E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.67|P-value:9.17E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.33|P-value:4.41E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.22|P-value:4.75E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.43|P-value:2.35E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.22|P-value:4.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.21|P-value:7.73E-6 ID:SGTC_2793|Compound:7325131|FD-Score:3.02|P-value:9.67E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.05|P-value:9.49E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.45|P-value:2.20E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.82|P-value:4.95E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.61|P-value:1.13E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-4.16|P-value:1.10E-5 ID:SGTC_3229|Compound:9132204|FD-Score:-3.13|P-value:7.04E-4 ID:SGTC_3233|Compound:9132340|FD-Score:6.12|P-value:1.72E-10 ID:SGTC_3246|Compound:9135460|FD-Score:-4.36|P-value:4.31E-6 ID:SGTC_3248|Compound:9135562|FD-Score:-3.07|P-value:8.70E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.01|P-value:9.90E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.30|P-value:3.86E-4

Top fitness defect scores for YOL026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3233 9132340 6.12 49.5 µM 1.72E-10 1 4.63E-10 0.82
2 SGTC_3145 9085516 4.61 49.5 µM 1.13E-6 fatty acid desaturase (OLE1) 8 2.04E-6 0.21
3 SGTC_1821 st053465 4.41 65.6 µM 2.97E-6 1 5.10E-6 0.39
4 SGTC_1813 st051246 4.34 8.6 µM 4.15E-6 TSC3-RPN4 2 7.02E-6 0.01
5 SGTC_2529 gangaleoidin 4.33 93.6 µM 4.41E-6 4 7.43E-6 0.96
6 SGTC_2788 5282734 4.21 71.4 µM 7.73E-6 4 1.27E-5 0.07
7 SGTC_1125 tnp00248 4.12 1.3 µM 1.20E-5 7 1.93E-5 0.03
8 SGTC_2700 st077718 4.02 96.8 µM 1.85E-5 5 2.92E-5 0.35
9 SGTC_1511 0906-3109 4.01 28.5 µM 1.96E-5 excess fatty acid 11 3.09E-5 0.09
10 SGTC_433 pimozide 3.90 108.0 µM 3.12E-5 2 4.81E-5 0.85
11 SGTC_877 0771-0151 3.84 33.1 µM 4.07E-5 1 6.19E-5 0.43
12 SGTC_2416 tofa 3.80 880.0 nM 4.82E-5 sphingolipid biosynthesis & PDR1 6 7.29E-5 0.03
13 SGTC_1974 st069448 3.67 26.9 µM 8.31E-5 5 1.23E-4 0.06
14 SGTC_3140 9094243 3.60 49.5 µM 1.09E-4 8 1.58E-4 0.08
15 SGTC_848 0368-0089 3.29 85.6 µM 3.57E-4 iron homeostasis 14 4.92E-4 0.04
16 SGTC_2537 larixol 3.22 68.9 µM 4.75E-4 13 6.47E-4 0.02
17 SGTC_2707 st078556 3.22 66.6 µM 4.75E-4 6 6.47E-4 0.14
18 SGTC_843 0310-0051 3.21 143.0 µM 4.80E-4 5 6.53E-4 0.01
19 SGTC_430 0958-0115 3.21 16.4 µM 4.93E-4 21 6.71E-4 0.03
20 SGTC_308 4092-1169 3.19 104.0 µM 5.33E-4 plasma membrane duress 15 7.22E-4 0.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.72E-18 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.142 1.20E-16 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.126 2.31E-13 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.118 8.36E-12 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.111 1.11E-10 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.111 1.14E-10 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.108 2.93E-10 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.099 9.18E-9 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.099 9.82E-9 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.093 7.74E-8 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.092 8.45E-8 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 1.06E-7 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.090 1.95E-7 YGL044C RNA15 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.089 2.54E-7 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.089 2.69E-7 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress