YOL027C / MDM38

Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL027C / MDM38

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.43|P-value:6.76E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.86|P-value:1.63E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.18|P-value:4.97E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.99|P-value:9.95E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.83|P-value:1.73E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.49|P-value:1.43E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.58|P-value:1.06E-7 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.70|P-value:3.93E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.56|P-value:4.44E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.87|P-value:4.61E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:4.00|P-value:9.52E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.38|P-value:2.28E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.82|P-value:2.32E-10 ID:SGTC_941|Compound:3237-0776|FD-Score:4.40|P-value:2.10E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:3.36|P-value:8.35E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:5.94|P-value:1.75E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.43|P-value:6.71E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.77|P-value:6.97E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.80|P-value:1.92E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.76E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.46|P-value:8.66E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.23|P-value:5.77E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.57|P-value:4.21E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.44|P-value:6.55E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.46|P-value:8.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:8.46E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.36|P-value:8.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.87|P-value:3.40E-20 ID:SGTC_1742|Compound:st038235|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-3.41|P-value:9.83E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-11.30|P-value:2.57E-25 ID:SGTC_1825|Compound:st052143|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.48|P-value:7.96E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.95|P-value:1.15E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.58|P-value:9.89E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.27|P-value:2.91E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:1.40E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.92|P-value:1.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.61|P-value:3.68E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.52|P-value:7.01E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.44|P-value:1.77E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.87|P-value:2.91E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.65|P-value:3.21E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.43|P-value:6.76E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.86|P-value:1.63E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.18|P-value:4.97E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.99|P-value:9.95E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.83|P-value:1.73E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.49|P-value:1.43E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.58|P-value:1.06E-7 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.70|P-value:3.93E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.56|P-value:4.44E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.87|P-value:4.61E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:4.00|P-value:9.52E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:4.38|P-value:2.28E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-6.82|P-value:2.32E-10 ID:SGTC_941|Compound:3237-0776|FD-Score:4.40|P-value:2.10E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:3.36|P-value:8.35E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:5.94|P-value:1.75E-8 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.43|P-value:6.71E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.77|P-value:6.97E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.80|P-value:1.92E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.76E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.46|P-value:8.66E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.23|P-value:5.77E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.57|P-value:4.21E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.44|P-value:6.55E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.46|P-value:8.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.36|P-value:8.46E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.36|P-value:8.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.87|P-value:3.40E-20 ID:SGTC_1742|Compound:st038235|FD-Score:3.37|P-value:8.21E-4 ID:SGTC_1806|Compound:st050005|FD-Score:-3.41|P-value:9.83E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-11.30|P-value:2.57E-25 ID:SGTC_1825|Compound:st052143|FD-Score:3.33|P-value:9.18E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.48|P-value:7.96E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.95|P-value:1.15E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.58|P-value:9.89E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.27|P-value:2.91E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:1.40E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.92|P-value:1.87E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.61|P-value:3.68E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.52|P-value:7.01E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.44|P-value:1.77E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.87|P-value:2.91E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.65|P-value:3.21E-4

Top fitness defect scores for YOL027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 9.87 42.4 µM 3.40E-20 75 2.94E-23
2 SGTC_236 1509-0011 7.86 5.3 µM 1.63E-13 253 1.95E-15
3 SGTC_2583 asiatic acid 6.27 100.0 µM 2.91E-9 10 1.80E-10
4 SGTC_949 1165-0505 5.94 146.0 µM 1.75E-8 6 1.45E-9
5 SGTC_628 1636-0253 5.58 16.0 µM 1.06E-7 sphingolipid biosynthesis & PDR1 10 1.18E-8
6 SGTC_1255 0566-0045 5.23 221.0 µM 5.77E-7 excess fatty acid 9 8.47E-8
7 SGTC_3336 9143619 4.87 71.4 µM 2.91E-6 7 5.55E-7
8 SGTC_1948 st076329 4.58 66.6 µM 9.89E-6 14 2.30E-6
9 SGTC_623 k072-0108 4.49 16.9 µM 1.43E-5 heme biosynthesis & mitochondrial translocase 5 3.53E-6
10 SGTC_3202 9113761 4.44 49.5 µM 1.77E-5 31 4.50E-6
11 SGTC_941 3237-0776 4.40 460.0 µM 2.10E-5 6 5.49E-6
12 SGTC_907 3448-6986 4.38 75.5 µM 2.28E-5 18 6.04E-6
13 SGTC_275 trichlorophene 4.18 5.7 µM 4.97E-5 mitochondrial stress 215 1.49E-5
14 SGTC_852 0418-0143 4.00 439.0 µM 9.52E-5 calcium & mitochondrial duress 67 3.16E-5
15 SGTC_333 3486-0131 3.99 40.1 µM 9.95E-5 amide catabolism 10 3.33E-5
16 SGTC_1891 st059073 3.95 26.2 µM 1.15E-4 TSC3-RPN4 23 3.93E-5
17 SGTC_2588 indole-3-carbinol 3.89 100.0 µM 1.40E-4 47 4.95E-5
18 SGTC_402 epigallocatechin gallate 3.83 10.0 µM 1.73E-4 29 6.29E-5
19 SGTC_1086 cerivastatin 3.83 2.2 µM 1.76E-4 azole & statin 15 6.42E-5
20 SGTC_1071 trifluoperazine 3.80 6.3 µM 1.92E-4 30 7.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 5.89E-73 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.300 1.16E-70 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.296 4.26E-69 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.294 6.75E-68 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.294 7.07E-68 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.289 1.41E-65 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.284 3.67E-63 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.284 3.90E-63 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.280 3.37E-61 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.278 2.13E-60 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.272 5.76E-58 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.271 1.38E-57 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.266 2.22E-55 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.262 8.46E-54 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.260 7.08E-53 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p