HIPHOP chemogenomics database

YOL027C / MDM38

Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL027C / MDM38

Click on Significant Values for Screen Details

Top fitness defect scores for YOL027C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1635	st007035	9.87	42.4 µM	3.40E-20		75	2.94E-23
2	SGTC_236	1509-0011	7.86	5.3 µM	1.63E-13		253	1.95E-15
3	SGTC_2583	asiatic acid	6.27	100.0 µM	2.91E-9		10	1.80E-10
4	SGTC_949	1165-0505	5.94	146.0 µM	1.75E-8		6	1.45E-9
5	SGTC_628	1636-0253	5.58	16.0 µM	1.06E-7	sphingolipid biosynthesis & PDR1	10	1.18E-8
6	SGTC_1255	0566-0045	5.23	221.0 µM	5.77E-7	excess fatty acid	9	8.47E-8
7	SGTC_3336	9143619	4.87	71.4 µM	2.91E-6		7	5.55E-7
8	SGTC_1948	st076329	4.58	66.6 µM	9.89E-6		14	2.30E-6
9	SGTC_623	k072-0108	4.49	16.9 µM	1.43E-5	heme biosynthesis & mitochondrial translocase	5	3.53E-6
10	SGTC_3202	9113761	4.44	49.5 µM	1.77E-5		31	4.50E-6
11	SGTC_941	3237-0776	4.40	460.0 µM	2.10E-5		6	5.49E-6
12	SGTC_907	3448-6986	4.38	75.5 µM	2.28E-5		18	6.04E-6
13	SGTC_275	trichlorophene	4.18	5.7 µM	4.97E-5	mitochondrial stress	215	1.49E-5
14	SGTC_852	0418-0143	4.00	439.0 µM	9.52E-5	calcium & mitochondrial duress	67	3.16E-5
15	SGTC_333	3486-0131	3.99	40.1 µM	9.95E-5	amide catabolism	10	3.33E-5
16	SGTC_1891	st059073	3.95	26.2 µM	1.15E-4	TSC3-RPN4	23	3.93E-5
17	SGTC_2588	indole-3-carbinol	3.89	100.0 µM	1.40E-4		47	4.95E-5
18	SGTC_402	epigallocatechin gallate	3.83	10.0 µM	1.73E-4		29	6.29E-5
19	SGTC_1086	cerivastatin	3.83	2.2 µM	1.76E-4	azole & statin	15	6.42E-5
20	SGTC_1071	trifluoperazine	3.80	6.3 µM	1.92E-4		30	7.11E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.304	5.89E-73	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.300	1.16E-70	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.296	4.26E-69	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.294	6.75E-68	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.294	7.07E-68	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.289	1.41E-65	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.284	3.67E-63	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.284	3.90E-63	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.280	3.37E-61	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.278	2.13E-60	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.272	5.76E-58	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.271	1.38E-57	YLL009C	COX17	hom	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.266	2.22E-55	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.262	8.46E-54	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.260	7.08E-53	YPL189C-A	COA2	hom	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p