YOL029C_p

Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL029C / YOL029C

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.08|P-value:1.83E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:3.12E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.30|P-value:4.31E-8 ID:SGTC_814|Compound:3342-0569|FD-Score:3.30|P-value:4.08E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.78|P-value:6.37E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.20|P-value:7.89E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.21|P-value:5.66E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.03|P-value:6.02E-10 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.13|P-value:7.47E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.66|P-value:1.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.83|P-value:8.21E-7 ID:SGTC_1716|Compound:st033144|FD-Score:-3.87|P-value:6.38E-5 ID:SGTC_1723|Compound:st034307|FD-Score:5.34|P-value:3.43E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.19|P-value:6.07E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.80|P-value:6.02E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.39|P-value:2.91E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-3.25|P-value:6.66E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.41|P-value:2.70E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.30|P-value:6.72E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.99|P-value:2.65E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.13|P-value:7.37E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.26|P-value:6.42E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:5.18|P-value:8.26E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.96|P-value:4.28E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.13|P-value:7.56E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.55|P-value:1.61E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.35|P-value:4.58E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.71|P-value:8.47E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.60|P-value:1.83E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-6.73|P-value:1.03E-11 ID:SGTC_2968|Compound:9090663|FD-Score:-4.68|P-value:1.72E-6 ID:SGTC_2982|Compound:9019404|FD-Score:6.54|P-value:2.10E-11 ID:SGTC_2983|Compound:9022671|FD-Score:5.13|P-value:1.12E-7 ID:SGTC_3127|Compound:9126946|FD-Score:4.28|P-value:7.47E-6 ID:SGTC_3176|Compound:9106582|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.25|P-value:4.81E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.58|P-value:1.43E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.08|P-value:1.83E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:3.12E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.11|P-value:8.08E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.30|P-value:4.31E-8 ID:SGTC_814|Compound:3342-0569|FD-Score:3.30|P-value:4.08E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.22|P-value:5.40E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.78|P-value:6.37E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.20|P-value:7.89E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.21|P-value:5.66E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.03|P-value:6.02E-10 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.13|P-value:7.47E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.66|P-value:1.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.83|P-value:8.21E-7 ID:SGTC_1716|Compound:st033144|FD-Score:-3.87|P-value:6.38E-5 ID:SGTC_1723|Compound:st034307|FD-Score:5.34|P-value:3.43E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.19|P-value:6.07E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.80|P-value:6.02E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.39|P-value:2.91E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_1983|Compound:st071813|FD-Score:-3.25|P-value:6.66E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.41|P-value:2.70E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.30|P-value:6.72E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.99|P-value:2.65E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.13|P-value:7.37E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.26|P-value:6.42E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:5.18|P-value:8.26E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.96|P-value:4.28E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.13|P-value:7.56E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.55|P-value:1.61E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.35|P-value:4.58E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.71|P-value:8.47E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.60|P-value:1.83E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-6.73|P-value:1.03E-11 ID:SGTC_2968|Compound:9090663|FD-Score:-4.68|P-value:1.72E-6 ID:SGTC_2982|Compound:9019404|FD-Score:6.54|P-value:2.10E-11 ID:SGTC_2983|Compound:9022671|FD-Score:5.13|P-value:1.12E-7 ID:SGTC_3127|Compound:9126946|FD-Score:4.28|P-value:7.47E-6 ID:SGTC_3176|Compound:9106582|FD-Score:3.45|P-value:2.36E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.25|P-value:4.81E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.58|P-value:1.43E-4

Top fitness defect scores for YOL029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2982 9019404 6.54 26.0 µM 2.10E-11 5 3.00E-11
2 SGTC_1212 0520-0165 6.03 585.0 µM 6.02E-10 4 8.33E-10
3 SGTC_1723 st034307 5.34 2.5 µM 3.43E-8 mitochondrial processes 10 4.55E-8
4 SGTC_778 3456-2434 5.30 196.0 µM 4.31E-8 mitochondrial response to ROS 34 5.71E-8
5 SGTC_2504 purpurogallin 5.18 52.3 µM 8.26E-8 RPP1 & pyrimidine depletion 6 1.09E-7
6 SGTC_2983 9022671 5.13 13.0 µM 1.12E-7 60S ribosome export 4 1.47E-7
7 SGTC_2157 5649910 4.30 96.4 µM 6.72E-6 15 8.41E-6
8 SGTC_3127 9126946 4.28 49.5 µM 7.47E-6 ERG2 14 9.33E-6
9 SGTC_25 0118-0223 4.08 35.7 µM 1.83E-5 12 2.26E-5
10 SGTC_2167 5876490 3.99 200.0 µM 2.65E-5 30 3.27E-5
11 SGTC_1837 st055472 3.80 66.5 µM 6.02E-5 22 7.33E-5
12 SGTC_849 0386-0493 3.78 241.0 µM 6.37E-5 23 7.75E-5
13 SGTC_2844 9010103 3.71 26.0 µM 8.47E-5 39 1.03E-4
14 SGTC_1580 hydrocortisone 21-hemisuccinate 3.66 43.2 µM 1.04E-4 24 1.26E-4
15 SGTC_1403 3909-7815 3.65 62.9 µM 1.07E-4 22 1.30E-4
16 SGTC_3325 9138760 3.58 55.2 µM 1.43E-4 Golgi 36 1.72E-4
17 SGTC_2681 menadione 3.55 3.2 µM 1.61E-4 superoxide 37 1.93E-4
18 SGTC_1935 st074532 3.48 41.6 µM 2.11E-4 54 2.53E-4
19 SGTC_3176 9106582 3.45 49.5 µM 2.36E-4 3 2.82E-4
20 SGTC_2104 5389443 3.41 200.0 µM 2.70E-4 35 3.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.14E-8 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.091 1.16E-7 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.089 2.71E-7 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.079 4.91E-6 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.074 1.65E-5 YML096W_p YML096W_p hom Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
0.071 4.29E-5 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.070 5.01E-5 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.069 5.92E-5 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.069 6.69E-5 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.066 1.23E-4 YHR158C KEL1 hom Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.066 1.32E-4 YKR100C SKG1 hom Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
0.066 1.46E-4 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.065 1.50E-4 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.064 2.19E-4 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.063 2.41E-4 YDR194W-A_p YDR194W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR