YOL033W / MSE1

Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL033W / MSE1

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:5.56|P-value:2.84E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:5.07E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.62|P-value:5.90E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.07|P-value:1.60E-13 ID:SGTC_264|Compound:promethazine|FD-Score:4.04|P-value:1.47E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.77|P-value:9.25E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.83|P-value:7.30E-16 ID:SGTC_385|Compound:1494-0393|FD-Score:3.56|P-value:7.23E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.23|P-value:7.36E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.59|P-value:6.58E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.95|P-value:4.16E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:4.18|P-value:8.85E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.80|P-value:2.28E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.05|P-value:9.52E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.87|P-value:2.63E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.49|P-value:6.32E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.47|P-value:9.68E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.98|P-value:3.83E-6 ID:SGTC_1613|Compound:st002381|FD-Score:6.42|P-value:3.53E-9 ID:SGTC_1618|Compound:st003135|FD-Score:-4.48|P-value:1.87E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.54|P-value:5.42E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.71|P-value:4.53E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.16|P-value:1.08E-6 ID:SGTC_1772|Compound:st048439|FD-Score:3.62|P-value:5.95E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.26|P-value:4.36E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.67|P-value:9.76E-8 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.46|P-value:9.88E-4 ID:SGTC_1987|Compound:st072290|FD-Score:6.21|P-value:1.13E-8 ID:SGTC_1988|Compound:st071872|FD-Score:-3.81|P-value:2.22E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.06|P-value:1.37E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.35|P-value:4.74E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.86|P-value:6.59E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.83|P-value:2.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.34|P-value:4.97E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.69|P-value:7.98E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.49|P-value:9.01E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.82|P-value:4.65E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.47|P-value:1.93E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.08|P-value:1.26E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.97|P-value:1.86E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.91|P-value:2.28E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.68|P-value:8.38E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.09|P-value:1.43E-6 ID:SGTC_2918|Compound:7977171|FD-Score:-3.83|P-value:2.09E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-4.58|P-value:1.26E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.30|P-value:3.82E-5 ID:SGTC_3094|Compound:9117742|FD-Score:6.02|P-value:2.99E-8 ID:SGTC_3126|Compound:9127922|FD-Score:-4.24|P-value:4.79E-5 ID:SGTC_3140|Compound:9094243|FD-Score:7.86|P-value:6.55E-13 ID:SGTC_3189|Compound:9110682|FD-Score:3.64|P-value:5.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.70|P-value:4.57E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.58|P-value:6.75E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.56|P-value:2.84E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:5.07E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.62|P-value:5.90E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.07|P-value:1.60E-13 ID:SGTC_264|Compound:promethazine|FD-Score:4.04|P-value:1.47E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.77|P-value:9.25E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.83|P-value:7.30E-16 ID:SGTC_385|Compound:1494-0393|FD-Score:3.56|P-value:7.23E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.23|P-value:7.36E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.59|P-value:6.58E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.95|P-value:4.16E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:4.18|P-value:8.85E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.80|P-value:2.28E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.05|P-value:9.52E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.87|P-value:2.63E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.49|P-value:6.32E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.47|P-value:9.68E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.98|P-value:3.83E-6 ID:SGTC_1613|Compound:st002381|FD-Score:6.42|P-value:3.53E-9 ID:SGTC_1618|Compound:st003135|FD-Score:-4.48|P-value:1.87E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.54|P-value:5.42E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.71|P-value:4.53E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.16|P-value:1.08E-6 ID:SGTC_1772|Compound:st048439|FD-Score:3.62|P-value:5.95E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.26|P-value:4.36E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.67|P-value:9.76E-8 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.46|P-value:9.88E-4 ID:SGTC_1987|Compound:st072290|FD-Score:6.21|P-value:1.13E-8 ID:SGTC_1988|Compound:st071872|FD-Score:-3.81|P-value:2.22E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.06|P-value:1.37E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.35|P-value:4.74E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.86|P-value:6.59E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.83|P-value:2.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.34|P-value:4.97E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.69|P-value:7.98E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.49|P-value:9.01E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.82|P-value:4.65E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.47|P-value:1.93E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.08|P-value:1.26E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.97|P-value:1.86E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.91|P-value:2.28E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.68|P-value:8.38E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.09|P-value:1.43E-6 ID:SGTC_2918|Compound:7977171|FD-Score:-3.83|P-value:2.09E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:-4.58|P-value:1.26E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.30|P-value:3.82E-5 ID:SGTC_3094|Compound:9117742|FD-Score:6.02|P-value:2.99E-8 ID:SGTC_3126|Compound:9127922|FD-Score:-4.24|P-value:4.79E-5 ID:SGTC_3140|Compound:9094243|FD-Score:7.86|P-value:6.55E-13 ID:SGTC_3189|Compound:9110682|FD-Score:3.64|P-value:5.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.70|P-value:4.57E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.58|P-value:6.75E-4

Top fitness defect scores for YOL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 8.83 1.1 µM 7.30E-16 mitochondrial stress 67 5.02E-19
2 SGTC_236 1509-0011 8.07 5.3 µM 1.60E-13 248 3.49E-16
3 SGTC_3140 9094243 7.86 49.5 µM 6.55E-13 1 1.94E-15
4 SGTC_1613 st002381 6.42 52.1 µM 3.53E-9 3 6.61E-11
5 SGTC_1987 st072290 6.21 61.9 µM 1.13E-8 2 2.71E-10
6 SGTC_3094 9117742 6.02 49.5 µM 2.99E-8 4 8.85E-10
7 SGTC_691 1548-0686 5.95 185.0 µM 4.16E-8 3 1.32E-9
8 SGTC_2250 alverine citrate 5.86 130.0 µM 6.59E-8 56 2.31E-9
9 SGTC_63 0099-0242 5.56 26.7 µM 2.84E-7 mitochondrial stress 35 1.36E-8
10 SGTC_1610 st001799 4.98 48.1 µM 3.83E-6 2 3.21E-7
11 SGTC_275 trichlorophene 4.77 5.7 µM 9.25E-6 mitochondrial stress 187 9.37E-7
12 SGTC_2109 5483026 4.35 200.0 µM 4.74E-5 RSC complex & mRNA processing 19 6.81E-6
13 SGTC_2496 diffractaic acid 4.34 79.8 µM 4.97E-5 15 7.21E-6
14 SGTC_414 piperonyl butoxide 4.23 100.0 µM 7.36E-5 4 1.16E-5
15 SGTC_767 0929-0023 4.18 86.0 µM 8.85E-5 TRP & mitochondrial translation 65 1.45E-5
16 SGTC_2798 7813637 4.08 45.5 µM 1.26E-4 27 2.23E-5
17 SGTC_2055 5235184 4.06 200.0 µM 1.37E-4 ERG2 26 2.47E-5
18 SGTC_264 promethazine 4.04 12.5 mM 1.47E-4 DNA intercalators 49 2.68E-5
19 SGTC_2826 7992541 3.97 19.5 µM 1.86E-4 19 3.57E-5
20 SGTC_2835 9006588 3.91 71.4 µM 2.28E-4 41 4.58E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 2.57E-95 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.340 1.74E-91 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.335 2.26E-88 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.325 2.44E-83 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.319 4.36E-80 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.318 7.61E-80 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.315 2.27E-78 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.313 4.31E-77 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.312 1.55E-76 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.311 2.80E-76 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.311 5.74E-76 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.309 4.58E-75 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.308 1.23E-74 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.307 2.97E-74 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.306 1.09E-73 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated