YOL036W_p

Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL036W / YOL036W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.34|P-value:3.74E-14 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.86|P-value:3.18E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.96|P-value:2.21E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.83|P-value:4.86E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:8.77|P-value:1.99E-19 ID:SGTC_616|Compound:4092-0450|FD-Score:3.98|P-value:2.54E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:5.26|P-value:4.16E-8 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:7.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.06|P-value:9.49E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.65|P-value:1.01E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:5.58E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.05|P-value:1.35E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.67|P-value:9.57E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.05|P-value:9.68E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.04|P-value:8.95E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-6.20|P-value:1.07E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.94|P-value:3.09E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.22|P-value:5.32E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.66|P-value:9.79E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.21|P-value:5.04E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.60|P-value:1.44E-6 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.97|P-value:2.68E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.71|P-value:8.16E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.52|P-value:1.52E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.36|P-value:4.63E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.81|P-value:4.68E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.44|P-value:2.07E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.09|P-value:7.68E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.15|P-value:6.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.34|P-value:3.74E-14 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.86|P-value:3.18E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.96|P-value:2.21E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.83|P-value:4.86E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:8.77|P-value:1.99E-19 ID:SGTC_616|Compound:4092-0450|FD-Score:3.98|P-value:2.54E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:5.26|P-value:4.16E-8 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:7.62E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.06|P-value:9.49E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.65|P-value:1.01E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:5.58E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.05|P-value:1.35E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.67|P-value:9.57E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.05|P-value:9.68E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.04|P-value:8.95E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-6.20|P-value:1.07E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.94|P-value:3.09E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.22|P-value:5.32E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.66|P-value:9.79E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.21|P-value:5.04E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.60|P-value:1.44E-6 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.97|P-value:2.68E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.71|P-value:8.16E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.52|P-value:1.52E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.36|P-value:4.63E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.81|P-value:4.68E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.44|P-value:2.07E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.09|P-value:7.68E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.15|P-value:6.88E-4

Top fitness defect scores for YOL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_588 3970-1144 8.77 52.9 µM 1.99E-19 2 9.30E-19
2 SGTC_58 0957-0393 7.34 9.0 µM 3.74E-14 cell wall 151 1.09E-13
3 SGTC_801 0866-0028 5.26 10.1 µM 4.16E-8 9 7.09E-8
4 SGTC_1048 3161-0300 5.05 24.5 µM 1.35E-7 9 2.20E-7
5 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.96 819.4 µM 2.21E-7 heat shock/prefoldin 20 3.54E-7
6 SGTC_2536 dehydroabietamide 4.60 32.0 µM 1.44E-6 14 2.15E-6
7 SGTC_2853 9015042 4.36 58.4 µM 4.63E-6 18 6.64E-6
8 SGTC_616 4092-0450 3.98 108.0 µM 2.54E-5 15 3.42E-5
9 SGTC_2676 harmalol 3.97 100.0 µM 2.68E-5 mitochondrial processes 10 3.60E-5
10 SGTC_2034 5197015 3.94 53.1 µM 3.09E-5 SWF1 & branched chain AA biosynthesis 26 4.13E-5
11 SGTC_366 0181-0206 3.83 4.3 µM 4.86E-5 Golgi 47 6.40E-5
12 SGTC_803 4488-1585 3.72 147.0 µM 7.62E-5 15 9.86E-5
13 SGTC_2814 7977482 3.71 43.0 µM 8.16E-5 61 1.05E-4
14 SGTC_1172 0370-0043 3.67 85.0 µM 9.57E-5 31 1.23E-4
15 SGTC_2420 aureobasidin a 3.66 50.0 nM 9.79E-5 55 1.26E-4
16 SGTC_956 1185-0240 3.65 191.0 µM 1.01E-4 30 1.30E-4
17 SGTC_1430 4049-0248 3.61 69.1 µM 1.20E-4 27 1.53E-4
18 SGTC_2831 7999036 3.50 19.5 µM 1.82E-4 64 2.29E-4
19 SGTC_2937 9044753 3.46 11.3 µM 2.15E-4 60S ribosome export 53 2.68E-4
20 SGTC_2320 7373003 3.31 200.0 µM 3.78E-4 46 4.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 6.16E-33 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.202 2.84E-32 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.196 1.77E-30 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.189 2.68E-28 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.177 4.01E-25 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.171 2.55E-23 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.161 6.13E-21 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.159 1.66E-20 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.156 9.05E-20 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.153 4.38E-19 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.149 3.85E-18 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.147 1.17E-17 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.146 1.60E-17 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.144 6.32E-17 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.140 4.55E-16 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress