YOL038C-A_p

Putative protein of unknown function; identified by SAGE analysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL038C-A / YOL038C-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:2.82|P-value:8.43E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.38|P-value:8.37E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:3.49|P-value:5.05E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.02|P-value:3.85E-6 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.94|P-value:6.06E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.13|P-value:2.43E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.57|P-value:1.82E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.01|P-value:4.51E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.04|P-value:3.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.10|P-value:2.75E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.47|P-value:5.52E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.24|P-value:1.51E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.55|P-value:3.81E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.05|P-value:3.42E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.57|P-value:3.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:2.97|P-value:4.62E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.34|P-value:9.92E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.03|P-value:4.22E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.24|P-value:1.50E-4 ID:SGTC_1853|Compound:st056710|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.05|P-value:3.86E-4 ID:SGTC_2154|Compound:5570129|FD-Score:2.96|P-value:4.81E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-2.88|P-value:7.42E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.06|P-value:3.77E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.16|P-value:1.84E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.84|P-value:8.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:2.78|P-value:9.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-2.94|P-value:5.99E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.37|P-value:8.76E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-2.83|P-value:9.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.83|P-value:9.08E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-2.81|P-value:9.92E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.32|P-value:1.27E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.07|P-value:3.46E-6 ID:SGTC_3080|Compound:9117754|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.87|P-value:8.40E-6 ID:SGTC_3130|Compound:9127414|FD-Score:2.82|P-value:8.27E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.49|P-value:5.81E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.23|P-value:1.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.43|P-value:6.74E-5 ID:SGTC_3279|Compound:9140807|FD-Score:2.82|P-value:8.36E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.95|P-value:1.78E-8 ID:SGTC_3286|Compound:9117135|FD-Score:-4.69|P-value:1.08E-7 ID:SGTC_3289|Compound:9119912|FD-Score:4.30|P-value:8.32E-7 ID:SGTC_3338|Compound:9144300|FD-Score:2.83|P-value:7.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.82|P-value:8.43E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.38|P-value:8.37E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:3.49|P-value:5.05E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.02|P-value:3.85E-6 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.94|P-value:6.06E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.13|P-value:2.43E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.57|P-value:1.82E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.01|P-value:4.51E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.04|P-value:3.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.10|P-value:2.75E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.47|P-value:5.52E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.24|P-value:1.51E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.55|P-value:3.81E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.05|P-value:3.42E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.57|P-value:3.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:2.97|P-value:4.62E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.34|P-value:9.92E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.03|P-value:4.22E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.24|P-value:1.50E-4 ID:SGTC_1853|Compound:st056710|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.05|P-value:3.86E-4 ID:SGTC_2154|Compound:5570129|FD-Score:2.96|P-value:4.81E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-2.88|P-value:7.42E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.06|P-value:3.77E-4 ID:SGTC_2462|Compound:5162487|FD-Score:4.16|P-value:1.84E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.84|P-value:8.88E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:2.78|P-value:9.65E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-2.94|P-value:5.99E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.37|P-value:8.76E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-2.83|P-value:9.02E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.83|P-value:9.08E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-2.81|P-value:9.92E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.32|P-value:1.27E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.07|P-value:3.46E-6 ID:SGTC_3080|Compound:9117754|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.87|P-value:8.40E-6 ID:SGTC_3130|Compound:9127414|FD-Score:2.82|P-value:8.27E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.49|P-value:5.81E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.23|P-value:1.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.43|P-value:6.74E-5 ID:SGTC_3279|Compound:9140807|FD-Score:2.82|P-value:8.36E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.95|P-value:1.78E-8 ID:SGTC_3286|Compound:9117135|FD-Score:-4.69|P-value:1.08E-7 ID:SGTC_3289|Compound:9119912|FD-Score:4.30|P-value:8.32E-7 ID:SGTC_3338|Compound:9144300|FD-Score:2.83|P-value:7.88E-4

Top fitness defect scores for YOL038C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3280 9140961 4.95 49.5 µM 1.78E-8 60S ribosome export 6 3.62E-7
2 SGTC_826 1683-5028 4.57 118.0 µM 1.82E-7 8 2.42E-6
3 SGTC_3289 9119912 4.30 71.4 µM 8.32E-7 11 8.37E-6
4 SGTC_2462 5162487 4.16 171.8 µM 1.84E-6 14 1.61E-5
5 SGTC_236 1509-0011 4.02 5.3 µM 3.85E-6 381 2.93E-5
6 SGTC_3088 9117578 3.87 49.5 µM 8.40E-6 amide catabolism 8 5.55E-5
7 SGTC_1480 1070-0044 3.57 41.2 µM 3.49E-5 29 1.78E-4
8 SGTC_1247 0448-0043 3.55 5.8 µM 3.81E-5 ERG2 68 1.91E-4
9 SGTC_101 0490-5701 3.49 117.5 µM 5.05E-5 26 2.41E-4
10 SGTC_1122 capsaicin 3.47 818.6 nM 5.52E-5 41 2.59E-4
11 SGTC_585 0kpi-0023 3.46 191.0 µM 5.83E-5 33 2.71E-4
12 SGTC_3272 9137413 3.43 49.5 µM 6.74E-5 28 3.05E-4
13 SGTC_68 0986-0284 3.38 82.8 µM 8.37E-5 99 3.65E-4
14 SGTC_2699 st077704 3.37 54.6 µM 8.76E-5 endomembrane recycling 74 3.79E-4
15 SGTC_1695 st026914 3.34 34.5 µM 9.92E-5 37 4.19E-4
16 SGTC_2688 kanamycin b 3.33 96.7 µM 1.05E-4 calcium & mitochondrial duress 471 4.40E-4
17 SGTC_1781 st038725 3.24 66.3 µM 1.50E-4 NEO1 141 5.88E-4
18 SGTC_1228 0124-0032 3.24 52.5 µM 1.51E-4 44 5.93E-4
19 SGTC_3263 9137018 3.23 49.5 µM 1.62E-4 45 6.26E-4
20 SGTC_778 3456-2434 3.13 196.0 µM 2.43E-4 mitochondrial response to ROS 122 8.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.18E-21 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.163 2.26E-21 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.161 5.70E-21 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.159 2.58E-20 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.157 7.53E-20 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.156 9.41E-20 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.154 3.40E-19 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.152 9.12E-19 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.152 1.06E-18 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.149 3.93E-18 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.149 4.03E-18 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.146 1.68E-17 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.144 6.49E-17 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.142 1.67E-16 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.140 4.01E-16 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase