YOL039W / RPP2A

Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL039W / RPP2A

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.73|P-value:3.71E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.65|P-value:5.12E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.54|P-value:6.82E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.57|P-value:6.09E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.45|P-value:9.10E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.83|P-value:2.64E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.44|P-value:2.92E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:4.30|P-value:4.94E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:4.15|P-value:8.79E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:5.38|P-value:5.64E-7 ID:SGTC_870|Compound:0573-2213|FD-Score:3.43|P-value:9.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.57|P-value:6.61E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.91|P-value:4.43E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.47|P-value:2.83E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:5.33|P-value:7.35E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:6.44|P-value:2.94E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:4.14|P-value:9.08E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.91|P-value:4.45E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.75|P-value:8.83E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:5.86|P-value:6.00E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.48|P-value:8.21E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.96|P-value:1.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.87|P-value:2.32E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.48|P-value:8.22E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.62|P-value:5.33E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.03|P-value:1.34E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.11|P-value:1.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.64|P-value:4.92E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.05|P-value:2.45E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:5.12|P-value:1.80E-6 ID:SGTC_1625|Compound:st003711|FD-Score:4.69|P-value:1.13E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.76|P-value:8.19E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.45|P-value:9.48E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.14|P-value:9.01E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.50|P-value:2.30E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.61|P-value:5.50E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.67|P-value:1.31E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-5.45|P-value:4.48E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.85|P-value:2.44E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.21|P-value:7.05E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.46|P-value:8.63E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.68|P-value:4.66E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.75|P-value:3.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.43|P-value:9.50E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.94|P-value:3.98E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-4.29|P-value:5.66E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.14|P-value:9.07E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.09|P-value:1.13E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.34|P-value:4.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.59|P-value:5.71E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.73|P-value:3.71E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.65|P-value:5.12E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.54|P-value:6.82E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.57|P-value:6.09E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.45|P-value:9.10E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.83|P-value:2.64E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.44|P-value:2.92E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:4.30|P-value:4.94E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:4.15|P-value:8.79E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:5.38|P-value:5.64E-7 ID:SGTC_870|Compound:0573-2213|FD-Score:3.43|P-value:9.61E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.57|P-value:6.61E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.91|P-value:4.43E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:-4.47|P-value:2.83E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:5.33|P-value:7.35E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:6.44|P-value:2.94E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:4.14|P-value:9.08E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.91|P-value:4.45E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.75|P-value:8.83E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:5.86|P-value:6.00E-8 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.48|P-value:8.21E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.96|P-value:1.71E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.87|P-value:2.32E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.48|P-value:8.22E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.62|P-value:5.33E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.03|P-value:1.34E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.11|P-value:1.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.64|P-value:4.92E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.05|P-value:2.45E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:5.12|P-value:1.80E-6 ID:SGTC_1625|Compound:st003711|FD-Score:4.69|P-value:1.13E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.75|P-value:3.70E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.76|P-value:8.19E-6 ID:SGTC_2009|Compound:4012297|FD-Score:-3.45|P-value:9.48E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.14|P-value:9.01E-5 ID:SGTC_2109|Compound:5483026|FD-Score:4.50|P-value:2.30E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.61|P-value:5.50E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.67|P-value:1.31E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-5.45|P-value:4.48E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.85|P-value:2.44E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.21|P-value:7.05E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.46|P-value:8.63E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.68|P-value:4.66E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.75|P-value:3.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.43|P-value:9.50E-4 ID:SGTC_2948|Compound:9070189|FD-Score:4.94|P-value:3.98E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-4.29|P-value:5.66E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.14|P-value:9.07E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.09|P-value:1.13E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.34|P-value:4.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.59|P-value:5.71E-4

Top fitness defect scores for YOL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_934 2950-0684 6.44 338.0 µM 2.94E-9 4 6.03E-11
2 SGTC_965 1291-5240 5.86 308.0 µM 6.00E-8 7 2.38E-9
3 SGTC_711 k292-0785 5.38 179.0 µM 5.64E-7 DNA intercalators 7 3.66E-8
4 SGTC_932 2857-0803 5.33 154.0 µM 7.35E-7 10 5.05E-8
5 SGTC_1464 k208-0027 5.12 110.0 µM 1.80E-6 12 1.50E-7
6 SGTC_1449 4112-4002 5.05 201.0 µM 2.45E-6 RPP1 & pyrimidine depletion 10 2.19E-7
7 SGTC_2948 9070189 4.94 9.4 µM 3.98E-6 plasma membrane duress 32 3.94E-7
8 SGTC_920 mycophenolic acid 4.91 780.4 nM 4.43E-6 8 4.49E-7
9 SGTC_944 3370-0224 4.91 231.0 µM 4.45E-6 11 4.51E-7
10 SGTC_1977 st070720 4.76 65.3 µM 8.19E-6 3 9.45E-7
11 SGTC_946 3434-1334 4.75 87.4 µM 8.83E-6 15 1.04E-6
12 SGTC_1625 st003711 4.69 30.1 µM 1.13E-5 calcium & mitochondrial duress 21 1.40E-6
13 SGTC_2109 5483026 4.50 200.0 µM 2.30E-5 RSC complex & mRNA processing 15 3.32E-6
14 SGTC_424 splitomicin 4.44 100.0 mM 2.92E-5 11 4.43E-6
15 SGTC_3041 9091929 4.34 49.5 µM 4.38E-5 redox potentiating 15 7.24E-6
16 SGTC_517 1365-0151 4.30 113.0 µM 4.94E-5 28 8.38E-6
17 SGTC_2150 5556613 4.21 200.0 µM 7.05E-5 14 1.29E-5
18 SGTC_518 1021-0119 4.15 62.6 µM 8.79E-5 ERG2 30 1.69E-5
19 SGTC_2020 4017018 4.14 200.0 µM 9.01E-5 15 1.74E-5
20 SGTC_2981 9013952 4.14 39.0 µM 9.07E-5 39 1.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.67E-7 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.082 1.85E-6 YLR406C RPL31B hom Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.080 4.04E-6 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.079 5.12E-6 YNL049C SFB2 hom Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p
0.078 6.69E-6 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.078 6.88E-6 YDR174W HMO1 hom Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.077 7.29E-6 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.26E-5 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.075 1.28E-5 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.075 1.59E-5 YEL033W_p MTC7_p hom Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
0.074 1.57E-5 YNR062C_p YNR062C_p hom Putative membrane protein of unknown function
0.073 2.41E-5 YGL147C RPL9A hom Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
0.071 3.48E-5 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.071 3.51E-5 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.070 5.40E-5 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication