YOL040C / RPS15

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL040C / RPS15

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.93|P-value:8.66E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.03|P-value:6.57E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.08|P-value:5.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.55|P-value:1.38E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.05|P-value:6.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.93|P-value:4.07E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.89|P-value:9.49E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:6.85|P-value:2.01E-8 ID:SGTC_366|Compound:0181-0206|FD-Score:8.09|P-value:4.37E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.25|P-value:9.69E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:4.04|P-value:6.42E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.33|P-value:2.72E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.48|P-value:6.96E-8 ID:SGTC_496|Compound:calpeptin|FD-Score:5.97|P-value:8.87E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:4.38|P-value:2.37E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.79|P-value:9.89E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.92|P-value:8.93E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.66|P-value:2.97E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.48|P-value:1.75E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.24|P-value:3.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.93|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.29|P-value:3.09E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.89|P-value:9.63E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.55|P-value:1.02E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.22|P-value:3.82E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.79|P-value:4.72E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.79|P-value:9.89E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.15|P-value:4.62E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.87|P-value:3.59E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.58|P-value:1.25E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.03|P-value:6.60E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.32|P-value:2.82E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.85|P-value:3.88E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.37|P-value:1.66E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-4.76|P-value:5.23E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.82|P-value:9.13E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.81|P-value:4.49E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-3.97|P-value:5.89E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.91|P-value:4.33E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.10|P-value:5.31E-4 ID:SGTC_2053|Compound:5265679|FD-Score:5.18|P-value:1.72E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.28|P-value:3.20E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.45|P-value:1.89E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-8.24|P-value:1.11E-11 ID:SGTC_2290|Compound:7904846|FD-Score:4.15|P-value:4.62E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.06|P-value:5.97E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-5.34|P-value:6.90E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-7.23|P-value:2.18E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-7.31|P-value:1.43E-9 ID:SGTC_2460|Compound:5552655|FD-Score:5.29|P-value:1.17E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.94|P-value:8.45E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.34|P-value:2.66E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.36|P-value:2.53E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.47|P-value:1.79E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.02|P-value:5.13E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.77|P-value:5.11E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:9.22|P-value:6.73E-14 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.44|P-value:4.74E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.39|P-value:1.70E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.02|P-value:2.20E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.04|P-value:4.43E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.61|P-value:8.58E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.37|P-value:2.42E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.56|P-value:1.35E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.21|P-value:3.89E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.89|P-value:7.48E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.92|P-value:6.78E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-7.04|P-value:5.42E-9 ID:SGTC_2936|Compound:9038235|FD-Score:5.22|P-value:1.49E-5 ID:SGTC_2964|Compound:9083345|FD-Score:5.25|P-value:1.33E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.94|P-value:8.37E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.59|P-value:9.02E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.62|P-value:1.13E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.90|P-value:4.47E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.94|P-value:6.53E-4 ID:SGTC_3068|Compound:9116768|FD-Score:5.16|P-value:1.84E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.93|P-value:8.71E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.36|P-value:2.48E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.41|P-value:7.40E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-3.85|P-value:8.30E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.50|P-value:1.22E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-4.48|P-value:1.28E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.85|P-value:8.24E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.88|P-value:9.98E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.38|P-value:1.79E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-4.14|P-value:3.67E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.93|P-value:8.66E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.03|P-value:6.57E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.08|P-value:5.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.55|P-value:1.38E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.05|P-value:6.09E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.93|P-value:4.07E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.89|P-value:9.49E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:6.85|P-value:2.01E-8 ID:SGTC_366|Compound:0181-0206|FD-Score:8.09|P-value:4.37E-11 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.25|P-value:9.69E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:4.04|P-value:6.42E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.33|P-value:2.72E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.48|P-value:6.96E-8 ID:SGTC_496|Compound:calpeptin|FD-Score:5.97|P-value:8.87E-7 ID:SGTC_502|Compound:l-744,832|FD-Score:4.38|P-value:2.37E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.79|P-value:9.89E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.92|P-value:8.93E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.66|P-value:2.97E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.48|P-value:1.75E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.24|P-value:3.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.93|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.29|P-value:3.09E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.89|P-value:9.63E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.55|P-value:1.02E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.22|P-value:3.82E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.79|P-value:4.72E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.79|P-value:9.89E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.15|P-value:4.62E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.87|P-value:3.59E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.58|P-value:1.25E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.03|P-value:6.60E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.32|P-value:2.82E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.85|P-value:3.88E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.37|P-value:1.66E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-4.76|P-value:5.23E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.82|P-value:9.13E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.81|P-value:4.49E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-3.97|P-value:5.89E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.91|P-value:4.33E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.10|P-value:5.31E-4 ID:SGTC_2053|Compound:5265679|FD-Score:5.18|P-value:1.72E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.28|P-value:3.20E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.45|P-value:1.89E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-8.24|P-value:1.11E-11 ID:SGTC_2290|Compound:7904846|FD-Score:4.15|P-value:4.62E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.06|P-value:5.97E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-5.34|P-value:6.90E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-7.23|P-value:2.18E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-7.31|P-value:1.43E-9 ID:SGTC_2460|Compound:5552655|FD-Score:5.29|P-value:1.17E-5 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:3.94|P-value:8.45E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.34|P-value:2.66E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.36|P-value:2.53E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.47|P-value:1.79E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.02|P-value:5.13E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.77|P-value:5.11E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:9.22|P-value:6.73E-14 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.44|P-value:4.74E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-4.39|P-value:1.70E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.02|P-value:2.20E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.04|P-value:4.43E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.61|P-value:8.58E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.37|P-value:2.42E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.56|P-value:1.35E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.21|P-value:3.89E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.89|P-value:7.48E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.92|P-value:6.78E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-7.04|P-value:5.42E-9 ID:SGTC_2936|Compound:9038235|FD-Score:5.22|P-value:1.49E-5 ID:SGTC_2964|Compound:9083345|FD-Score:5.25|P-value:1.33E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.94|P-value:8.37E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.59|P-value:9.02E-5 ID:SGTC_3049|Compound:9092223|FD-Score:4.62|P-value:1.13E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.90|P-value:4.47E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.94|P-value:6.53E-4 ID:SGTC_3068|Compound:9116768|FD-Score:5.16|P-value:1.84E-5 ID:SGTC_3118|Compound:9124250|FD-Score:3.93|P-value:8.71E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.36|P-value:2.48E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.41|P-value:7.40E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-3.85|P-value:8.30E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.50|P-value:1.22E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-4.48|P-value:1.28E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.85|P-value:8.24E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.88|P-value:9.98E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.38|P-value:1.79E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-4.14|P-value:3.67E-4

Top fitness defect scores for YOL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2658 polymyxin b sulfate 9.22 77.0 µM 6.73E-14 NEO1 2 1.51E-20 0.17
2 SGTC_366 0181-0206 8.09 4.3 µM 4.37E-11 Golgi 1 3.10E-16 1.73
3 SGTC_364 0083-0097 6.85 67.7 µM 2.01E-8 1 3.71E-12 1.33
4 SGTC_1781 st038725 6.37 66.3 µM 1.66E-7 NEO1 4 9.32E-11 0.72
5 SGTC_496 calpeptin 5.97 138.0 µM 8.87E-7 1 1.21E-9 1.51
6 SGTC_800 3448-7362 5.66 155.0 µM 2.97E-6 translation 26 7.67E-9 0.01
7 SGTC_3203 9113543 5.41 49.5 µM 7.40E-6 2 3.08E-8 0.19
8 SGTC_2460 5552655 5.29 174.2 µM 1.17E-5 amide catabolism 4 6.19E-8 0.47
9 SGTC_2964 9083345 5.25 53.4 µM 1.33E-5 7 7.49E-8 0.83
10 SGTC_2936 9038235 5.22 15.6 µM 1.49E-5 3 8.99E-8 0.28
11 SGTC_2053 5265679 5.18 138.0 µM 1.72E-5 2 1.12E-7 0.79
12 SGTC_3068 9116768 5.16 49.5 µM 1.84E-5 2 1.24E-7 0.26
13 SGTC_264 promethazine 4.93 12.5 mM 4.07E-5 DNA intercalators 14 4.13E-7 0.14
14 SGTC_2005 4024620 4.91 188.0 µM 4.33E-5 2 4.54E-7 0.37
15 SGTC_3050 9093513 4.90 49.5 µM 4.47E-5 4 4.77E-7 0.42
16 SGTC_3049 9092223 4.62 49.5 µM 1.13E-4 2 1.94E-6 0.50
17 SGTC_1680 diphenhydramine 4.58 100.0 µM 1.25E-4 NEO1 10 2.29E-6 0.16
18 SGTC_2795 7780010 4.56 54.5 µM 1.35E-4 4 2.57E-6 0.18
19 SGTC_168 3970-0862 4.55 530.5 µM 1.38E-4 34 2.65E-6 0.08
20 SGTC_832 4083-0019 4.48 164.0 µM 1.75E-4 translation 20 3.79E-6 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 3.65E-49 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.212 2.57E-35 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.204 8.96E-33 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.197 1.33E-30 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.188 4.40E-28 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.177 3.62E-25 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.165 7.76E-22 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.163 2.06E-21 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.160 1.38E-20 YMR309C NIP1 het eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
0.158 3.59E-20 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.154 2.58E-19 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.152 8.40E-19 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.151 1.47E-18 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.151 1.73E-18 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.148 6.89E-18 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation