YOL041C / NOP12

Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL041C / NOP12

Click on Significant Values for Screen Details ID:SGTC_150|Compound:3970-0969|FD-Score:5.32|P-value:3.32E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:3.31|P-value:9.36E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:5.27|P-value:4.18E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.41|P-value:1.84E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.07|P-value:1.83E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.41|P-value:6.74E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.30|P-value:9.56E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.33|P-value:3.97E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.07|P-value:6.83E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.78|P-value:1.96E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.44|P-value:1.63E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.81|P-value:1.76E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.71|P-value:2.48E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.16|P-value:7.02E-7 ID:SGTC_1627|Compound:st003713|FD-Score:-5.67|P-value:1.09E-7 ID:SGTC_1630|Compound:st005209|FD-Score:4.11|P-value:5.78E-5 ID:SGTC_1633|Compound:st005664|FD-Score:6.39|P-value:1.28E-9 ID:SGTC_1673|Compound:st016611|FD-Score:5.16|P-value:6.90E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.92|P-value:1.18E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_2152|Compound:5568786|FD-Score:5.33|P-value:3.10E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.04|P-value:7.50E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.66|P-value:4.32E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.46|P-value:5.77E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.21|P-value:5.49E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.88|P-value:1.38E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.11|P-value:8.80E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.22|P-value:6.08E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.42|P-value:9.52E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.61|P-value:5.16E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.17|P-value:4.64E-5 ID:SGTC_2966|Compound:9084041|FD-Score:6.15|P-value:4.89E-9 ID:SGTC_3002|Compound:9075603|FD-Score:3.48|P-value:5.30E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-3.46|P-value:8.42E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.94|P-value:1.93E-6 ID:SGTC_3178|Compound:9107506|FD-Score:5.10|P-value:9.10E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.75|P-value:2.18E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.32|P-value:3.32E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:3.31|P-value:9.36E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:5.27|P-value:4.18E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.41|P-value:1.84E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-5.07|P-value:1.83E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.41|P-value:6.74E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.30|P-value:9.56E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.33|P-value:3.97E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.36|P-value:7.94E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.07|P-value:6.83E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.78|P-value:1.96E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.44|P-value:1.63E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.81|P-value:1.76E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.71|P-value:2.48E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.16|P-value:7.02E-7 ID:SGTC_1627|Compound:st003713|FD-Score:-5.67|P-value:1.09E-7 ID:SGTC_1630|Compound:st005209|FD-Score:4.11|P-value:5.78E-5 ID:SGTC_1633|Compound:st005664|FD-Score:6.39|P-value:1.28E-9 ID:SGTC_1673|Compound:st016611|FD-Score:5.16|P-value:6.90E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.92|P-value:1.18E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_2152|Compound:5568786|FD-Score:5.33|P-value:3.10E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.04|P-value:7.50E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-3.66|P-value:4.32E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.46|P-value:5.77E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.21|P-value:5.49E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.88|P-value:1.38E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.11|P-value:8.80E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.22|P-value:6.08E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.42|P-value:9.52E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.61|P-value:5.16E-4 ID:SGTC_2944|Compound:9067346|FD-Score:4.17|P-value:4.64E-5 ID:SGTC_2966|Compound:9084041|FD-Score:6.15|P-value:4.89E-9 ID:SGTC_3002|Compound:9075603|FD-Score:3.48|P-value:5.30E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_3109|Compound:9122853|FD-Score:-3.46|P-value:8.42E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.94|P-value:1.93E-6 ID:SGTC_3178|Compound:9107506|FD-Score:5.10|P-value:9.10E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.75|P-value:2.18E-4

Top fitness defect scores for YOL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1633 st005664 6.39 67.9 µM 1.28E-9 2 8.50E-11
2 SGTC_2966 9084041 6.15 48.0 µM 4.89E-9 6 3.99E-10
3 SGTC_2152 5568786 5.33 200.0 µM 3.10E-7 3 4.80E-8
4 SGTC_150 3970-0969 5.32 77.2 µM 3.32E-7 30 5.19E-8
5 SGTC_377 3970-0964 5.27 33.1 µM 4.18E-7 22 6.78E-8
6 SGTC_2424 5537928 5.21 59.2 µM 5.49E-7 12 9.28E-8
7 SGTC_1673 st016611 5.16 27.3 µM 6.90E-7 19 1.21E-7
8 SGTC_1468 k284-1086 5.16 134.0 µM 7.02E-7 DNA intercalators 10 1.23E-7
9 SGTC_2688 kanamycin b 5.11 96.7 µM 8.80E-7 calcium & mitochondrial duress 234 1.60E-7
10 SGTC_3178 9107506 5.10 49.5 µM 9.10E-7 2 1.66E-7
11 SGTC_3114 9122766 4.94 49.5 µM 1.93E-6 7 3.94E-7
12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.55 4.6 µM 1.02E-5 heat shock/prefoldin 28 2.67E-6
13 SGTC_1217 1183-1422 4.44 255.0 µM 1.63E-5 5 4.60E-6
14 SGTC_580 1123-0028 4.41 41.0 µM 1.84E-5 DNA damage response 26 5.27E-6
15 SGTC_1053 3366-3204 4.37 134.0 µM 2.14E-5 cell wall 26 6.28E-6
16 SGTC_1442 4112-3290 4.27 3.0 µM 3.12E-5 7 9.67E-6
17 SGTC_2944 9067346 4.17 25.6 µM 4.64E-5 17 1.52E-5
18 SGTC_1630 st005209 4.11 31.3 µM 5.78E-5 22 1.96E-5
19 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.07 1.2 µM 6.83E-5 iron homeostasis 39 2.38E-5
20 SGTC_2161 5662504 4.04 8.5 µM 7.50E-5 tubulin folding & SWR complex 17 2.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.59E-14 YKL081W TEF4 hom Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
0.094 4.50E-8 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.088 3.28E-7 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.081 2.48E-6 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.080 3.40E-6 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.079 4.54E-6 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.079 4.72E-6 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.079 5.41E-6 YMR100W MUB1 hom MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene
0.077 8.38E-6 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.076 9.26E-6 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.076 9.82E-6 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.076 9.56E-6 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.075 1.29E-5 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.074 1.89E-5 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.074 1.94E-5 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress