Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL042W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.147 | 1.25E-17 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |
0.113 | 6.38E-11 | YPL134C | ODC1 | hom | Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation |
0.111 | 1.01E-10 | YDR044W | HEM13 | het | Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
0.100 | 6.76E-9 | YPL221W | FLC1 | hom | Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance |
0.095 | 3.29E-8 | YEL017W | GTT3 | hom | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery |
0.090 | 1.77E-7 | YER151C | UBP3 | hom | Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress |
0.087 | 4.96E-7 | YML101C-A_d | YML101C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.084 | 1.25E-6 | YOR076C | SKI7 | hom | Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype |
0.083 | 1.66E-6 | YPR093C | ASR1 | hom | Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein |
0.082 | 1.84E-6 | YOR087W | YVC1 | hom | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock |
0.082 | 2.25E-6 | YBR077C | SLM4 | hom | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 |
0.080 | 3.42E-6 | YBR168W | PEX32 | hom | Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p |
0.079 | 4.22E-6 | YBR070C | ALG14 | het | Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases |
0.079 | 4.31E-6 | YCR022C_d | YCR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene |
0.078 | 5.85E-6 | YJR140C | HIR3 | hom | Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein |