HIPHOP chemogenomics database
YOL044W / PEX15 
Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL044W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.134 | 7.33E-15 | YML126C | ERG13 | het | 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis |
| 0.119 | 3.98E-12 | YOR366W_d | YOR366W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C |
| 0.101 | 5.37E-9 | YER176W | ECM32 | hom | DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
| 0.098 | 1.08E-8 | YER067W | RGI1 | hom | Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress |
| 0.094 | 4.80E-8 | YDR247W | VHS1 | hom | Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p |
| 0.087 | 3.94E-7 | YPL260W | YPL260W | hom | Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress |
| 0.085 | 9.07E-7 | YOR051C | ETT1 | hom | Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough |
| 0.078 | 5.43E-6 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |
| 0.078 | 6.22E-6 | YLR257W | YLR257W | hom | Protein of unknown function; protein abundance increases in response to DNA replication stress |
| 0.077 | 8.09E-6 | YMR209C_p | YMR209C_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene |
| 0.075 | 1.33E-5 | YDR314C | RAD34 | hom | Protein involved in nucleotide excision repair (NER); homologous to RAD4 |
| 0.074 | 1.78E-5 | YPL277C_p | YPL277C_p | hom | Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels |
| 0.074 | 1.80E-5 | YBR221C | PDB1 | hom | E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria |
| 0.074 | 1.89E-5 | YER072W | VTC1 | hom | Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress |
| 0.074 | 1.98E-5 | YHR063C | PAN5 | hom | 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE |