YOL044W / PEX15

Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL044W / PEX15

Click on Significant Values for Screen Details ID:SGTC_208|Compound:k072-0098|FD-Score:2.88|P-value:9.53E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.21|P-value:2.58E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.05|P-value:6.22E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:5.36E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:3.17E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.63|P-value:2.97E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:-2.90|P-value:8.57E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.14|P-value:3.96E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.09|P-value:4.38E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.09|P-value:4.26E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:4.33|P-value:1.46E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:3.01|P-value:5.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.97|P-value:9.37E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.13|P-value:3.70E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-4.39|P-value:1.05E-6 ID:SGTC_1519|Compound:esterone|FD-Score:4.46|P-value:7.67E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.88|P-value:9.43E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:7.49E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.49|P-value:6.39E-7 ID:SGTC_1917|Compound:st066507|FD-Score:5.08|P-value:2.11E-8 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.75|P-value:2.66E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.54|P-value:6.59E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.17|P-value:3.03E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.18|P-value:3.08E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.68|P-value:2.18E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.70|P-value:3.13E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.26|P-value:2.14E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.73|P-value:2.83E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-2.89|P-value:8.76E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.47|P-value:6.92E-7 ID:SGTC_2787|Compound:5284540|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.23|P-value:2.50E-4 ID:SGTC_2829|Compound:7992743|FD-Score:6.28|P-value:6.07E-12 ID:SGTC_2966|Compound:9084041|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.96|P-value:9.25E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.45|P-value:9.66E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.60|P-value:4.93E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.16|P-value:3.15E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.13|P-value:3.62E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.31|P-value:1.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.48|P-value:8.30E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:2.88|P-value:9.53E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.21|P-value:2.58E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.05|P-value:6.22E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:5.36E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.17|P-value:3.17E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:4.63|P-value:2.97E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:-2.90|P-value:8.57E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.14|P-value:3.96E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.09|P-value:4.38E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.09|P-value:4.26E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:4.33|P-value:1.46E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:3.01|P-value:5.85E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.97|P-value:9.37E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.13|P-value:3.70E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-4.39|P-value:1.05E-6 ID:SGTC_1519|Compound:esterone|FD-Score:4.46|P-value:7.67E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.88|P-value:9.43E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.51|P-value:7.49E-5 ID:SGTC_1911|Compound:st060208|FD-Score:4.49|P-value:6.39E-7 ID:SGTC_1917|Compound:st066507|FD-Score:5.08|P-value:2.11E-8 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.75|P-value:2.66E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.54|P-value:6.59E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.17|P-value:3.03E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.18|P-value:3.08E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.40|P-value:1.24E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.68|P-value:2.18E-7 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.70|P-value:3.13E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.26|P-value:2.14E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.73|P-value:2.83E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-2.89|P-value:8.76E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.47|P-value:6.92E-7 ID:SGTC_2787|Compound:5284540|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.23|P-value:2.50E-4 ID:SGTC_2829|Compound:7992743|FD-Score:6.28|P-value:6.07E-12 ID:SGTC_2966|Compound:9084041|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_3023|Compound:9089636|FD-Score:-3.96|P-value:9.25E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.45|P-value:9.66E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.60|P-value:4.93E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.16|P-value:3.15E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.13|P-value:3.62E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.31|P-value:1.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.48|P-value:8.30E-5

Top fitness defect scores for YOL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2829 7992743 6.28 58.4 µM 6.07E-12 6 1.68E-10
2 SGTC_1917 st066507 5.08 28.5 µM 2.11E-8 Golgi 18 1.89E-7
3 SGTC_2397 5161689 4.68 200.0 µM 2.18E-7 17 1.42E-6
4 SGTC_542 3381-0244 4.63 89.3 µM 2.97E-7 23 1.85E-6
5 SGTC_1911 st060208 4.49 74.3 µM 6.39E-7 22 3.58E-6
6 SGTC_1519 esterone 4.46 74.0 µM 7.67E-7 DNA intercalators 10 4.19E-6
7 SGTC_937 3122-0005 4.33 46.7 µM 1.46E-6 19 7.30E-6
8 SGTC_2594 a-mangostin 4.26 100.0 µM 2.14E-6 24 1.02E-5
9 SGTC_682 0kpi-0099 4.14 17.0 µM 3.96E-6 62 1.73E-5
10 SGTC_290 2043-6722 4.05 48.1 µM 6.22E-6 7 2.56E-5
11 SGTC_1120 ficusin 3.97 1.8 µM 9.37E-6 27 3.64E-5
12 SGTC_927 2425-1185 3.92 123.0 µM 1.18E-5 26 4.44E-5
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.75 70.1 µM 2.66E-5 33 8.98E-5
14 SGTC_2595 hexamethylquercetagetin 3.73 100.0 µM 2.83E-5 33 9.48E-5
15 SGTC_453 enantio-paf c16 3.59 10.0 µM 5.36E-5 177 1.64E-4
16 SGTC_2015 5119600 3.54 184.0 µM 6.59E-5 39 1.97E-4
17 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.51 61.8 µM 7.49E-5 ergosterol biosynthesis 16 2.20E-4
18 SGTC_2344 7990960 3.40 77.0 µM 1.24E-4 43 3.40E-4
19 SGTC_3299 9121982 3.37 43.1 µM 1.40E-4 49 3.77E-4
20 SGTC_3255 9139072 3.31 49.5 µM 1.80E-4 35 4.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.33E-15 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.119 3.98E-12 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.101 5.37E-9 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.098 1.08E-8 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.094 4.80E-8 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.087 3.94E-7 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.085 9.07E-7 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.078 5.43E-6 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.078 6.22E-6 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.077 8.09E-6 YMR209C_p YMR209C_p hom Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
0.075 1.33E-5 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.074 1.78E-5 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.074 1.80E-5 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.074 1.89E-5 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.074 1.98E-5 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE