YOL045W / PSK2

PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL045W / PSK2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.80|P-value:3.11E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-8.85|P-value:6.14E-17 ID:SGTC_354|Compound:2783-3500|FD-Score:3.41|P-value:7.41E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-5.50|P-value:1.27E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.22|P-value:4.25E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-4.53|P-value:1.10E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.58|P-value:3.90E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.89|P-value:2.60E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.79|P-value:2.07E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.36|P-value:8.03E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.60|P-value:9.22E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:7.91|P-value:7.78E-14 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.17|P-value:5.04E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.56|P-value:4.22E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.70|P-value:2.64E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.93|P-value:1.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.06|P-value:6.95E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.76|P-value:2.28E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.21|P-value:4.35E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.71|P-value:2.76E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.34|P-value:9.42E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.66|P-value:2.95E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.32|P-value:9.21E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.34|P-value:9.45E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.38|P-value:7.55E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.54|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.48|P-value:1.60E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.94|P-value:1.11E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.32|P-value:9.25E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.49|P-value:5.31E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.71|P-value:2.53E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-4.04|P-value:7.74E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.80|P-value:3.11E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:-8.85|P-value:6.14E-17 ID:SGTC_354|Compound:2783-3500|FD-Score:3.41|P-value:7.41E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-5.50|P-value:1.27E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.22|P-value:4.25E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-4.53|P-value:1.10E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.58|P-value:3.90E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.79|P-value:1.88E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.89|P-value:2.60E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.79|P-value:2.07E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.36|P-value:8.03E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.60|P-value:9.22E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:7.91|P-value:7.78E-14 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.17|P-value:5.04E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.56|P-value:4.22E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.70|P-value:2.64E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.93|P-value:1.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.06|P-value:6.95E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.66|P-value:3.28E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.76|P-value:2.28E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.21|P-value:4.35E-5 ID:SGTC_1702|Compound:st027038|FD-Score:3.71|P-value:2.76E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.34|P-value:9.42E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.66|P-value:2.95E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.32|P-value:9.21E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.34|P-value:9.45E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.38|P-value:7.55E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.54|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.48|P-value:1.60E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.94|P-value:1.11E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.32|P-value:9.25E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.49|P-value:5.31E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.71|P-value:2.53E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-4.04|P-value:7.74E-5

Top fitness defect scores for YOL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1081 sertraline 7.91 6.0 µM 7.78E-14 60S ribosome export 6 1.26E-15
2 SGTC_65 0798-0905 5.80 35.0 µM 3.11E-8 calcium & mitochondrial duress 36 3.22E-9
3 SGTC_2582 agaric acid 5.48 100.0 µM 1.60E-7 redox potentiating 191 2.09E-8
4 SGTC_582 0987-0078 4.89 156.0 µM 2.60E-6 calcium & mitochondrial duress 37 5.07E-7
5 SGTC_1069 diphenylcyclopropenone 4.60 8.5 µM 9.22E-6 21 2.15E-6
6 SGTC_385 1494-0393 4.22 12.4 µM 4.25E-5 14 1.23E-5
7 SGTC_1570 verbenone 4.21 133.0 µM 4.35E-5 12 1.26E-5
8 SGTC_1086 cerivastatin 4.17 2.2 µM 5.04E-5 azole & statin 9 1.50E-5
9 SGTC_779 1360-0071 3.79 233.0 µM 2.07E-4 fatty acid desaturase (OLE1) 33 7.47E-5
10 SGTC_1534 6-azauridine 3.76 81.6 µM 2.28E-4 RNA pol III & RNase P/MRP 28 8.35E-5
11 SGTC_1702 st027038 3.71 51.0 µM 2.76E-4 18 1.04E-4
12 SGTC_1507 4075-3230 3.66 155.0 µM 3.28E-4 13 1.26E-4
13 SGTC_2413 inermin 3.54 26.1 µM 4.83E-4 71 1.97E-4
14 SGTC_354 2783-3500 3.41 4.9 µM 7.41E-4 cell wall 71 3.20E-4
15 SGTC_1711 st032263 3.34 62.8 µM 9.42E-4 30 4.21E-4
16 SGTC_2292 7671323 3.34 168.1 µM 9.45E-4 RNA processing & uracil transport 64 4.22E-4
17 SGTC_51 1013-0126 3.31 23.4 µM 0.00104 42 4.70E-4
18 SGTC_2008 4012253 3.29 172.0 µM 0.00110 48 5.01E-4
19 SGTC_3299 9121982 3.26 43.1 µM 0.00122 58 5.66E-4
20 SGTC_2283 7944793 3.23 200.0 µM 0.00132 78 6.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 5.14E-15 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.134 6.64E-15 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.123 9.28E-13 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.118 7.94E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.115 2.53E-11 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.115 2.76E-11 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.112 7.42E-11 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.108 3.57E-10 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.107 5.28E-10 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.107 6.06E-10 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.106 6.78E-10 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.105 1.02E-9 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.103 1.98E-9 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.103 2.25E-9 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.101 4.60E-9 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1