YOL047C_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL047C / YOL047C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:2.94|P-value:8.69E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:2.92|P-value:9.28E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.90|P-value:9.99E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.76|P-value:3.07E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.31|P-value:6.13E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:3.03|P-value:6.33E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.76|P-value:2.75E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.03|P-value:5.65E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.15|P-value:3.60E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.71|P-value:3.81E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:2.95|P-value:8.27E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.28|P-value:2.36E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.69|P-value:2.41E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.75|P-value:2.92E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.01|P-value:3.84E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.92|P-value:1.49E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.04|P-value:6.09E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.43|P-value:1.17E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.00|P-value:6.47E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.89|P-value:9.55E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:1.80E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.54|P-value:6.53E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.91|P-value:8.98E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.13|P-value:4.31E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-4.29|P-value:2.11E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-3.07|P-value:4.81E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.12|P-value:4.49E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.02|P-value:6.43E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.09|P-value:4.95E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.61|P-value:5.94E-5 ID:SGTC_2161|Compound:5662504|FD-Score:5.22|P-value:1.28E-8 ID:SGTC_2341|Compound:7987486|FD-Score:3.72|P-value:3.71E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:6.07|P-value:4.73E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.66|P-value:4.87E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.03|P-value:5.66E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.14|P-value:4.09E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:2.94|P-value:8.69E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:2.92|P-value:9.28E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.90|P-value:9.99E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.76|P-value:3.07E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-5.31|P-value:6.13E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:3.03|P-value:6.33E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.76|P-value:2.75E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.03|P-value:5.65E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.15|P-value:3.60E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.71|P-value:3.81E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:2.95|P-value:8.27E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.28|P-value:2.36E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.69|P-value:2.41E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.75|P-value:2.92E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.01|P-value:3.84E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.92|P-value:1.49E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.04|P-value:6.09E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.43|P-value:1.17E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.00|P-value:6.47E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.89|P-value:9.55E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:1.80E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.54|P-value:6.53E-7 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.91|P-value:8.98E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.13|P-value:4.31E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-4.29|P-value:2.11E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-3.07|P-value:4.81E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.12|P-value:4.49E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.02|P-value:6.43E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.09|P-value:4.95E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.61|P-value:5.94E-5 ID:SGTC_2161|Compound:5662504|FD-Score:5.22|P-value:1.28E-8 ID:SGTC_2341|Compound:7987486|FD-Score:3.72|P-value:3.71E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:6.07|P-value:4.73E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.66|P-value:4.87E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.03|P-value:5.66E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.14|P-value:4.09E-4

Top fitness defect scores for YOL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 6.07 48.7 µM 4.73E-11 cell wall 58 6.52E-10
2 SGTC_2161 5662504 5.22 8.5 µM 1.28E-8 tubulin folding & SWR complex 6 8.93E-8
3 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.54 66.5 µM 6.53E-7 10 2.86E-6
4 SGTC_1142 3253-1408 3.92 9.8 µM 1.49E-5 12 4.49E-5
5 SGTC_359 0081-0058 3.76 15.9 µM 3.07E-5 60S ribosome export 53 8.52E-5
6 SGTC_2341 7987486 3.72 176.7 µM 3.71E-5 23 1.01E-4
7 SGTC_888 0916-0002 3.71 7.0 µM 3.81E-5 NEO1 52 1.03E-4
8 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.66 100.0 µM 4.87E-5 60S ribosome export 30 1.28E-4
9 SGTC_2160 5660466 3.61 132.9 µM 5.94E-5 60S ribosome export 29 1.53E-4
10 SGTC_1263 0774-1208 3.35 64.8 µM 1.80E-4 73 4.07E-4
11 SGTC_925 2064-1272 3.28 59.6 µM 2.36E-4 43 5.16E-4
12 SGTC_3150 9097574 3.14 49.5 µM 4.09E-4 27 8.40E-4
13 SGTC_1642 st009582 3.13 77.7 µM 4.31E-4 RPP1 & pyrimidine depletion 45 8.80E-4
14 SGTC_1810 st050138 3.12 53.0 µM 4.49E-4 PDR1 31 9.13E-4
15 SGTC_2143 5623677 3.09 140.5 µM 4.95E-4 20 9.94E-4
16 SGTC_8 0354-0001 3.07 70.0 µM 5.31E-4 136 0.00106
17 SGTC_1144 3486-0183 3.04 12.5 µM 6.09E-4 62 0.00120
18 SGTC_534 k292-0788 3.03 63.4 µM 6.33E-4 mitochondrial processes 63 0.00124
19 SGTC_1988 st071872 3.02 53.4 µM 6.43E-4 40 0.00125
20 SGTC_923 1900-2434 2.95 73.3 µM 8.27E-4 RNA processing & uracil transport 75 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.05E-14 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.125 3.76E-13 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.123 8.02E-13 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.117 1.00E-11 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.116 1.32E-11 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.109 2.41E-10 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 9.84E-10 YKR044W UIP5 hom Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
0.105 1.18E-9 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.102 2.99E-9 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.100 7.27E-9 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.099 7.69E-9 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.098 1.32E-8 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.094 5.24E-8 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.092 8.18E-8 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.090 1.68E-7 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria