YOL050C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL050C / YOL050C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.70|P-value:3.08E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.56|P-value:1.27E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:6.87|P-value:9.74E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:5.05|P-value:1.46E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:7.08|P-value:2.74E-11 ID:SGTC_295|Compound:k015-0027|FD-Score:6.01|P-value:1.27E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:4.51|P-value:1.49E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:5.64|P-value:8.82E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:5.86|P-value:2.86E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.12|P-value:1.03E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-3.35|P-value:9.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.03|P-value:9.29E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.09|P-value:8.52E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:5.20|P-value:7.13E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.39|P-value:2.40E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:12.20|P-value:4.78E-30 ID:SGTC_548|Compound:1436-0017|FD-Score:8.14|P-value:2.30E-14 ID:SGTC_562|Compound:3772-2733|FD-Score:5.68|P-value:7.04E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:5.23|P-value:6.20E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:3.50|P-value:5.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.89|P-value:2.96E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.55|P-value:4.96E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:23.40|P-value:5.79E-105 ID:SGTC_683|Compound:panaxydol|FD-Score:4.22|P-value:4.67E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:4.37E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.40|P-value:8.21E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:9.70|P-value:1.26E-19 ID:SGTC_907|Compound:3448-6986|FD-Score:3.92|P-value:1.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.67|P-value:3.28E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:36.10|P-value:2.23E-246 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.71|P-value:2.93E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-8.37|P-value:4.10E-15 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.61|P-value:4.11E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.33|P-value:3.07E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.46|P-value:2.35E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.73|P-value:2.66E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.66|P-value:1.69E-19 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.89|P-value:3.00E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.48|P-value:6.32E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.51|P-value:5.71E-4 ID:SGTC_1687|Compound:st020778|FD-Score:29.60|P-value:1.40E-165 ID:SGTC_1694|Compound:st024011|FD-Score:15.90|P-value:2.45E-49 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.66|P-value:7.60E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.67|P-value:7.48E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.76|P-value:2.39E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.05|P-value:8.76E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:5.09|P-value:1.23E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:7.12|P-value:2.02E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.83|P-value:4.15E-20 ID:SGTC_1988|Compound:st071872|FD-Score:3.40|P-value:8.10E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.51|P-value:5.82E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.39|P-value:8.33E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.43|P-value:1.99E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.55|P-value:1.22E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.90|P-value:1.49E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.59|P-value:4.41E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.66|P-value:7.73E-6 ID:SGTC_2482|Compound:5981709|FD-Score:5.07|P-value:1.31E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.45|P-value:6.89E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.20|P-value:4.90E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.59|P-value:1.13E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.95|P-value:1.73E-8 ID:SGTC_2691|Compound:st077356|FD-Score:3.43|P-value:7.54E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.71|P-value:6.16E-6 ID:SGTC_2703|Compound:st077852|FD-Score:-3.57|P-value:4.63E-4 ID:SGTC_2711|Compound:st079103|FD-Score:6.44|P-value:1.23E-9 ID:SGTC_2715|Compound:st079500|FD-Score:-4.26|P-value:3.95E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.99|P-value:1.93E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.00|P-value:6.02E-39 ID:SGTC_2829|Compound:7992743|FD-Score:6.33|P-value:2.28E-9 ID:SGTC_2832|Compound:7992762|FD-Score:-3.42|P-value:7.49E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.57|P-value:4.69E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.69|P-value:3.09E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.36|P-value:2.64E-5 ID:SGTC_2858|Compound:9025781|FD-Score:10.10|P-value:5.09E-21 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:9.58E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.42|P-value:7.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.90|P-value:1.49E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.30|P-value:3.35E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.44|P-value:7.03E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.16|P-value:5.86E-5 ID:SGTC_3121|Compound:9125696|FD-Score:-3.98|P-value:1.10E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.44|P-value:7.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-6.48|P-value:9.40E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:3.70|P-value:3.08E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.56|P-value:1.27E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:6.87|P-value:9.74E-11 ID:SGTC_227|Compound:fluconazole|FD-Score:5.05|P-value:1.46E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:7.08|P-value:2.74E-11 ID:SGTC_295|Compound:k015-0027|FD-Score:6.01|P-value:1.27E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:4.51|P-value:1.49E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:5.64|P-value:8.82E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:5.86|P-value:2.86E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-5.12|P-value:1.03E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-3.35|P-value:9.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.03|P-value:9.29E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.09|P-value:8.52E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:5.20|P-value:7.13E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.39|P-value:2.40E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:12.20|P-value:4.78E-30 ID:SGTC_548|Compound:1436-0017|FD-Score:8.14|P-value:2.30E-14 ID:SGTC_562|Compound:3772-2733|FD-Score:5.68|P-value:7.04E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:5.23|P-value:6.20E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:3.50|P-value:5.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.89|P-value:2.96E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.55|P-value:4.96E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:23.40|P-value:5.79E-105 ID:SGTC_683|Compound:panaxydol|FD-Score:4.22|P-value:4.67E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:4.37E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.40|P-value:8.21E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:9.70|P-value:1.26E-19 ID:SGTC_907|Compound:3448-6986|FD-Score:3.92|P-value:1.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.67|P-value:3.28E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:36.10|P-value:2.23E-246 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.71|P-value:2.93E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.00|P-value:1.07E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-8.37|P-value:4.10E-15 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.61|P-value:4.11E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.33|P-value:3.07E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.46|P-value:2.35E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.73|P-value:2.66E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.66|P-value:1.69E-19 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.89|P-value:3.00E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.48|P-value:6.32E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.51|P-value:5.71E-4 ID:SGTC_1687|Compound:st020778|FD-Score:29.60|P-value:1.40E-165 ID:SGTC_1694|Compound:st024011|FD-Score:15.90|P-value:2.45E-49 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.66|P-value:7.60E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.67|P-value:7.48E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.76|P-value:2.39E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.05|P-value:8.76E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:5.09|P-value:1.23E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:7.12|P-value:2.02E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.83|P-value:4.15E-20 ID:SGTC_1988|Compound:st071872|FD-Score:3.40|P-value:8.10E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.51|P-value:5.82E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.39|P-value:8.33E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.43|P-value:1.99E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.55|P-value:1.22E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.90|P-value:1.49E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.59|P-value:4.41E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-4.66|P-value:7.73E-6 ID:SGTC_2482|Compound:5981709|FD-Score:5.07|P-value:1.31E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.45|P-value:6.89E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.20|P-value:4.90E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.59|P-value:1.13E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.95|P-value:1.73E-8 ID:SGTC_2691|Compound:st077356|FD-Score:3.43|P-value:7.54E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-4.71|P-value:6.16E-6 ID:SGTC_2703|Compound:st077852|FD-Score:-3.57|P-value:4.63E-4 ID:SGTC_2711|Compound:st079103|FD-Score:6.44|P-value:1.23E-9 ID:SGTC_2715|Compound:st079500|FD-Score:-4.26|P-value:3.95E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.99|P-value:1.93E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.00|P-value:6.02E-39 ID:SGTC_2829|Compound:7992743|FD-Score:6.33|P-value:2.28E-9 ID:SGTC_2832|Compound:7992762|FD-Score:-3.42|P-value:7.49E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.57|P-value:4.69E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.69|P-value:3.09E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.36|P-value:2.64E-5 ID:SGTC_2858|Compound:9025781|FD-Score:10.10|P-value:5.09E-21 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:9.58E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.42|P-value:7.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.90|P-value:1.49E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.30|P-value:3.35E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.44|P-value:7.03E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.16|P-value:5.86E-5 ID:SGTC_3121|Compound:9125696|FD-Score:-3.98|P-value:1.10E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.44|P-value:7.14E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-6.48|P-value:9.40E-10

Top fitness defect scores for YOL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_955 1216-0110 36.10 33.0 µM 2.23E-246 sphingolipid biosynthesis & PDR1 1 2.57E-286
2 SGTC_1687 st020778 29.60 55.4 µM 1.40E-165 1 2.61E-192
3 SGTC_664 1222-0054 23.40 14.9 µM 5.79E-105 sphingolipid biosynthesis & PDR1 1 8.65E-122
4 SGTC_1694 st024011 15.90 44.9 µM 2.45E-49 ERG2 1 4.40E-57
5 SGTC_2752 diclazuril 14.00 33.1 µM 6.02E-39 12 5.33E-45
6 SGTC_505 gw-5074 12.20 63.9 µM 4.78E-30 10 1.19E-34
7 SGTC_2858 9025781 10.10 9.0 µM 5.09E-21 sphingolipid biosynthesis & PDR1 21 3.70E-24
8 SGTC_1877 wortmannin 9.83 25.0 µM 4.15E-20 17 4.23E-23
9 SGTC_841 0251-0215 9.70 91.2 µM 1.26E-19 14 1.54E-22
10 SGTC_1287 0971-0001 9.66 34.6 µM 1.69E-19 sphingolipid biosynthesis & PDR1 11 2.16E-22
11 SGTC_548 1436-0017 8.14 110.0 µM 2.30E-14 TSC3-RPN4 6 1.99E-16
12 SGTC_1249 0481-0015 7.46 10.2 µM 2.35E-12 4 4.29E-14
13 SGTC_1876 myriocin 7.12 605.0 nM 2.02E-11 10 5.21E-13
14 SGTC_293 4049-0273 7.08 38.5 µM 2.74E-11 3 7.41E-13
15 SGTC_157 1348-1695 6.87 65.8 µM 9.74E-11 iron homeostasis 16 3.23E-12
16 SGTC_2711 st079103 6.44 59.1 µM 1.23E-9 1 6.12E-11
17 SGTC_2829 7992743 6.33 58.4 µM 2.28E-9 5 1.25E-10
18 SGTC_453 enantio-paf c16 6.09 10.0 µM 8.52E-9 44 5.78E-10
19 SGTC_295 k015-0027 6.01 31.0 µM 1.27E-8 PDR1 3 9.18E-10
20 SGTC_352 k048-0007 5.86 5.1 µM 2.86E-8 ERAD & cell cycle 35 2.35E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.400 4.88E-129 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.396 4.33E-126 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.380 1.97E-115 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.360 2.23E-103 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.358 6.54E-102 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.341 2.44E-92 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.335 1.51E-88 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.326 9.40E-84 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.302 7.73E-72 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.282 1.90E-62 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.277 3.37E-60 YHR112C YHR112C hom Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway
0.277 3.54E-60 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.271 2.27E-57 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.260 7.90E-53 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.259 1.29E-52 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family