YOL051W / GAL11

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL051W / GAL11

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:4.40|P-value:2.95E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.12|P-value:7.67E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:6.06|P-value:9.85E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:6.02|P-value:1.16E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:10.40|P-value:1.38E-16 ID:SGTC_109|Compound:0132-0036|FD-Score:4.05|P-value:7.91E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.50|P-value:1.63E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:8.87|P-value:1.39E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:4.07|P-value:7.37E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.73|P-value:6.01E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:6.45|P-value:1.98E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.45|P-value:2.04E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.89|P-value:4.01E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.03|P-value:8.20E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.60|P-value:5.59E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:4.44|P-value:2.56E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.60|P-value:1.13E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:5.18|P-value:2.49E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:5.00|P-value:4.50E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.10|P-value:6.81E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.46|P-value:9.33E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.96|P-value:9.92E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.15|P-value:5.94E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.63|P-value:4.98E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.28|P-value:4.12E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.79|P-value:8.92E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.29|P-value:4.03E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.17|P-value:5.59E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:7.94|P-value:2.09E-10 ID:SGTC_1288|Compound:0973-0013|FD-Score:6.03|P-value:1.12E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.91|P-value:1.12E-12 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.00|P-value:1.26E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.70|P-value:1.16E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.73|P-value:3.51E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.77|P-value:9.51E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.90|P-value:6.21E-5 ID:SGTC_1608|Compound:st001473|FD-Score:6.32|P-value:3.47E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.02|P-value:4.19E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.03|P-value:4.05E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.00|P-value:1.15E-21 ID:SGTC_1694|Compound:st024011|FD-Score:12.90|P-value:8.55E-25 ID:SGTC_1700|Compound:st030840|FD-Score:10.50|P-value:4.23E-17 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.57|P-value:3.76E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.35|P-value:2.21E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.38|P-value:3.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.05|P-value:7.83E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.15|P-value:6.05E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.00|P-value:9.12E-4 ID:SGTC_1970|Compound:st070122|FD-Score:6.86|P-value:3.41E-8 ID:SGTC_1994|Compound:st072947|FD-Score:5.59|P-value:5.91E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.79|P-value:9.00E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.86|P-value:8.93E-4 ID:SGTC_2114|Compound:5491910|FD-Score:5.68|P-value:4.15E-6 ID:SGTC_2248|Compound:tofa|FD-Score:5.54|P-value:6.87E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.84|P-value:3.81E-8 ID:SGTC_2322|Compound:7413319|FD-Score:6.25|P-value:4.56E-7 ID:SGTC_2416|Compound:tofa|FD-Score:6.45|P-value:2.01E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.04|P-value:1.07E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:5.48|P-value:8.78E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.85|P-value:9.19E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.69|P-value:7.16E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.02|P-value:1.16E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.07|P-value:7.35E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.88|P-value:6.58E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.74|P-value:6.67E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:10.80|P-value:7.32E-18 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.00|P-value:1.37E-15 ID:SGTC_2949|Compound:9072542|FD-Score:4.22|P-value:4.91E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.72|P-value:6.33E-8 ID:SGTC_2980|Compound:9014342|FD-Score:10.50|P-value:5.74E-17 ID:SGTC_3007|Compound:9078383|FD-Score:4.31|P-value:3.84E-4 ID:SGTC_3025|Compound:9087895|FD-Score:6.33|P-value:3.28E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_3094|Compound:9117742|FD-Score:6.33|P-value:3.34E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-7.05|P-value:7.78E-9 ID:SGTC_3174|Compound:9107204|FD-Score:4.84|P-value:7.51E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.24|P-value:3.10E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.19|P-value:5.40E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:4.40|P-value:2.95E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.12|P-value:7.67E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:6.06|P-value:9.85E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:6.02|P-value:1.16E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:10.40|P-value:1.38E-16 ID:SGTC_109|Compound:0132-0036|FD-Score:4.05|P-value:7.91E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.50|P-value:1.63E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:8.87|P-value:1.39E-12 ID:SGTC_146|Compound:3448-8650|FD-Score:4.07|P-value:7.37E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.73|P-value:6.01E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:6.45|P-value:1.98E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.45|P-value:2.04E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.89|P-value:4.01E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.03|P-value:8.20E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.60|P-value:5.59E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:4.44|P-value:2.56E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.60|P-value:1.13E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:5.18|P-value:2.49E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:5.00|P-value:4.50E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.10|P-value:6.81E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.46|P-value:9.33E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.96|P-value:9.92E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.15|P-value:5.94E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.63|P-value:4.98E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.28|P-value:4.12E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.79|P-value:8.92E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.29|P-value:4.03E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.17|P-value:5.59E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:7.94|P-value:2.09E-10 ID:SGTC_1288|Compound:0973-0013|FD-Score:6.03|P-value:1.12E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.91|P-value:1.12E-12 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.00|P-value:1.26E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.70|P-value:1.16E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.73|P-value:3.51E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.77|P-value:9.51E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:4.90|P-value:6.21E-5 ID:SGTC_1608|Compound:st001473|FD-Score:6.32|P-value:3.47E-7 ID:SGTC_1635|Compound:st007035|FD-Score:5.02|P-value:4.19E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.03|P-value:4.05E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.00|P-value:1.15E-21 ID:SGTC_1694|Compound:st024011|FD-Score:12.90|P-value:8.55E-25 ID:SGTC_1700|Compound:st030840|FD-Score:10.50|P-value:4.23E-17 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.57|P-value:3.76E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.35|P-value:2.21E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.38|P-value:3.11E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.05|P-value:7.83E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.15|P-value:6.05E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.00|P-value:9.12E-4 ID:SGTC_1970|Compound:st070122|FD-Score:6.86|P-value:3.41E-8 ID:SGTC_1994|Compound:st072947|FD-Score:5.59|P-value:5.91E-6 ID:SGTC_2007|Compound:4011539|FD-Score:4.79|P-value:9.00E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.86|P-value:8.93E-4 ID:SGTC_2114|Compound:5491910|FD-Score:5.68|P-value:4.15E-6 ID:SGTC_2248|Compound:tofa|FD-Score:5.54|P-value:6.87E-6 ID:SGTC_2289|Compound:7946404|FD-Score:6.84|P-value:3.81E-8 ID:SGTC_2322|Compound:7413319|FD-Score:6.25|P-value:4.56E-7 ID:SGTC_2416|Compound:tofa|FD-Score:6.45|P-value:2.01E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.04|P-value:1.07E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:5.48|P-value:8.78E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.85|P-value:9.19E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:6.69|P-value:7.16E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.02|P-value:1.16E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.07|P-value:7.35E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.88|P-value:6.58E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.74|P-value:6.67E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:10.80|P-value:7.32E-18 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.00|P-value:1.37E-15 ID:SGTC_2949|Compound:9072542|FD-Score:4.22|P-value:4.91E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.72|P-value:6.33E-8 ID:SGTC_2980|Compound:9014342|FD-Score:10.50|P-value:5.74E-17 ID:SGTC_3007|Compound:9078383|FD-Score:4.31|P-value:3.84E-4 ID:SGTC_3025|Compound:9087895|FD-Score:6.33|P-value:3.28E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_3094|Compound:9117742|FD-Score:6.33|P-value:3.34E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-7.05|P-value:7.78E-9 ID:SGTC_3174|Compound:9107204|FD-Score:4.84|P-value:7.51E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-4.24|P-value:3.10E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.19|P-value:5.40E-4

Top fitness defect scores for YOL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1694 st024011 12.90 44.9 µM 8.55E-25 ERG2 6 1.55E-38
2 SGTC_1687 st020778 12.00 55.4 µM 1.15E-21 35 1.43E-33
3 SGTC_2741 miltefosine 10.80 3.0 µM 7.32E-18 5 1.57E-27
4 SGTC_1700 st030840 10.50 7.9 µM 4.23E-17 PDR1 4 2.54E-26
5 SGTC_2980 9014342 10.50 25.3 µM 5.74E-17 5 4.12E-26
6 SGTC_100 0086-0128 10.40 49.6 µM 1.38E-16 copper-dependent oxidative stress 5 1.66E-25
7 SGTC_2752 diclazuril 10.00 33.1 µM 1.37E-15 25 6.34E-24
8 SGTC_1304 1165-0502 8.91 251.0 µM 1.12E-12 13 2.66E-19
9 SGTC_134 0269-0018 8.87 6.9 µM 1.39E-12 48 3.72E-19
10 SGTC_1287 0971-0001 7.94 34.6 µM 2.09E-10 sphingolipid biosynthesis & PDR1 16 1.05E-15
11 SGTC_562 3772-2733 7.60 112.0 µM 1.13E-9 ERG2 18 1.54E-14
12 SGTC_1970 st070122 6.86 35.8 µM 3.41E-8 TSC3-RPN4 4 3.36E-12
13 SGTC_2289 7946404 6.84 165.1 µM 3.81E-8 28 4.02E-12
14 SGTC_156 3474-0145 6.73 5.6 µM 6.01E-8 endomembrane recycling 14 8.26E-12
15 SGTC_2959 9079155 6.72 11.0 µM 6.33E-8 3 8.95E-12
16 SGTC_2615 purpurogallin-4-carboxylic acid 6.69 100.0 µM 7.16E-8 redox potentiating 23 1.09E-11
17 SGTC_119 0121-0043 6.50 24.8 µM 1.63E-7 mitochondrial stress 21 4.00E-11
18 SGTC_157 1348-1695 6.45 65.8 µM 1.98E-7 iron homeostasis 19 5.44E-11
19 SGTC_2416 tofa 6.45 880.0 nM 2.01E-7 sphingolipid biosynthesis & PDR1 17 5.57E-11
20 SGTC_173 1273-0061 6.45 2.7 µM 2.04E-7 mitochondrial stress 99 5.69E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.514 3.96E-225 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.302 7.73E-72 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.286 2.68E-64 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.276 9.67E-60 YGR064W_d YGR064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.244 8.67E-47 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.235 2.86E-43 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.222 1.24E-38 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.215 2.02E-36 YPL254W HFI1 hom Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
0.211 6.13E-35 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.210 1.01E-34 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.203 2.34E-32 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.199 3.26E-31 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.183 1.54E-26 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.176 1.26E-24 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.175 2.01E-24 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data