YOL052C-A / DDR2

Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL052C-A / DDR2

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:4.91|P-value:5.05E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:4.18|P-value:1.56E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.65|P-value:1.42E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.25|P-value:5.96E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.20|P-value:7.13E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.43|P-value:3.39E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.65|P-value:1.42E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:5.37|P-value:4.44E-8 ID:SGTC_554|Compound:4483-2211|FD-Score:-5.12|P-value:1.73E-7 ID:SGTC_745|Compound:0469-0705|FD-Score:4.33|P-value:8.20E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.54|P-value:2.14E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.48|P-value:2.62E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.33|P-value:4.59E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.82|P-value:7.82E-7 ID:SGTC_938|Compound:3126-1755|FD-Score:3.16|P-value:8.10E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.98|P-value:3.65E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:4.28|P-value:1.02E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.78|P-value:8.35E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.49|P-value:2.59E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.86|P-value:2.62E-9 ID:SGTC_1329|Compound:1447-1697|FD-Score:6.12|P-value:5.55E-10 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.55|P-value:2.07E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:5.20|P-value:1.15E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.53|P-value:3.27E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.42|P-value:5.28E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.59|P-value:6.05E-18 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.30|P-value:6.72E-8 ID:SGTC_1571|Compound:st070080|FD-Score:4.99|P-value:3.42E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:7.02|P-value:1.39E-12 ID:SGTC_1902|Compound:st060212|FD-Score:-3.27|P-value:5.81E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.95|P-value:4.05E-7 ID:SGTC_2001|Compound:4023502|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.01|P-value:3.29E-5 ID:SGTC_2070|Compound:5230947|FD-Score:-3.20|P-value:7.38E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.17|P-value:7.97E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.68|P-value:1.26E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.34|P-value:7.89E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-3.20|P-value:7.39E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.90|P-value:5.14E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.75|P-value:1.11E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.43|P-value:3.17E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.29|P-value:5.31E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.16|P-value:8.30E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.90|P-value:5.20E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.78|P-value:9.53E-7 ID:SGTC_2791|Compound:5663188|FD-Score:-4.27|P-value:1.09E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.14|P-value:8.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.24|P-value:6.33E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.41|P-value:3.38E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:2.17E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.42|P-value:3.34E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.37|P-value:3.88E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.90|P-value:5.06E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.81|P-value:7.48E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.91|P-value:5.05E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:4.18|P-value:1.56E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.65|P-value:1.42E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.24|P-value:6.19E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.25|P-value:5.96E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.20|P-value:7.13E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.43|P-value:3.39E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.65|P-value:1.42E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:5.37|P-value:4.44E-8 ID:SGTC_554|Compound:4483-2211|FD-Score:-5.12|P-value:1.73E-7 ID:SGTC_745|Compound:0469-0705|FD-Score:4.33|P-value:8.20E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.54|P-value:2.14E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.48|P-value:2.62E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.33|P-value:4.59E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.82|P-value:7.82E-7 ID:SGTC_938|Compound:3126-1755|FD-Score:3.16|P-value:8.10E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.98|P-value:3.65E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:4.28|P-value:1.02E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.78|P-value:8.35E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.49|P-value:2.59E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.86|P-value:2.62E-9 ID:SGTC_1329|Compound:1447-1697|FD-Score:6.12|P-value:5.55E-10 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.55|P-value:2.07E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:5.20|P-value:1.15E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-4.53|P-value:3.27E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.62|P-value:1.55E-4 ID:SGTC_1523|Compound:st012844|FD-Score:4.42|P-value:5.28E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.59|P-value:6.05E-18 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.30|P-value:6.72E-8 ID:SGTC_1571|Compound:st070080|FD-Score:4.99|P-value:3.42E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:7.02|P-value:1.39E-12 ID:SGTC_1902|Compound:st060212|FD-Score:-3.27|P-value:5.81E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.95|P-value:4.05E-7 ID:SGTC_2001|Compound:4023502|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.01|P-value:3.29E-5 ID:SGTC_2070|Compound:5230947|FD-Score:-3.20|P-value:7.38E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.17|P-value:7.97E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.68|P-value:1.26E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.34|P-value:7.89E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-3.20|P-value:7.39E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.53|P-value:2.21E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.90|P-value:5.14E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.75|P-value:1.11E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.43|P-value:3.17E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.29|P-value:5.31E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.16|P-value:8.30E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.90|P-value:5.20E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.78|P-value:9.53E-7 ID:SGTC_2791|Compound:5663188|FD-Score:-4.27|P-value:1.09E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.14|P-value:8.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.24|P-value:6.33E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.16|P-value:8.31E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.41|P-value:3.38E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:2.17E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.42|P-value:3.34E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.37|P-value:3.88E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.90|P-value:5.06E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.81|P-value:7.48E-5

Top fitness defect scores for YOL052C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1564 D-Arginine 8.59 115.0 µM 6.05E-18 2 4.33E-18
2 SGTC_1574 spiramycin 7.02 23.7 µM 1.39E-12 3 1.11E-12
3 SGTC_1329 1447-1697 6.12 50.6 µM 5.55E-10 2 4.69E-10
4 SGTC_1320 1313-0481 5.86 95.3 µM 2.62E-9 6 2.25E-9
5 SGTC_553 k007-0256 5.37 45.7 µM 4.44E-8 heme biosynthesis & mitochondrial translocase 8 3.91E-8
6 SGTC_1565 sinapyl alcohol 5.30 95.1 µM 6.72E-8 4 5.94E-8
7 SGTC_1342 1486-1464 5.20 234.0 µM 1.15E-7 2 1.02E-7
8 SGTC_1571 st070080 4.99 73.4 µM 3.42E-7 3 3.06E-7
9 SGTC_1952 st077036 4.95 64.1 µM 4.05E-7 11 3.63E-7
10 SGTC_236 1509-0011 4.91 5.3 µM 5.05E-7 328 4.54E-7
11 SGTC_907 3448-6986 4.82 75.5 µM 7.82E-7 10 7.06E-7
12 SGTC_2790 5423970 4.78 71.4 µM 9.53E-7 endomembrane recycling 40 8.61E-7
13 SGTC_2596 sinensetin 4.75 100.0 µM 1.11E-6 16 1.00E-6
14 SGTC_1523 st012844 4.42 44.7 µM 5.28E-6 60S ribosome export 9 4.85E-6
15 SGTC_2310 7668677 4.34 200.0 µM 7.89E-6 18 7.27E-6
16 SGTC_745 0469-0705 4.33 296.0 µM 8.20E-6 mitochondrial processes 14 7.55E-6
17 SGTC_955 1216-0110 4.28 33.0 µM 1.02E-5 sphingolipid biosynthesis & PDR1 57 9.43E-6
18 SGTC_1339 1486-1321 4.24 22.7 µM 1.22E-5 ERG2 14 1.13E-5
19 SGTC_319 1348-1596 4.18 45.5 µM 1.56E-5 RSC & ERG11 16 1.45E-5
20 SGTC_2003 4023581 4.01 200.0 µM 3.29E-5 cell wall signaling 33 3.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.85E-10 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.108 3.00E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.108 3.05E-10 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.105 1.11E-9 YOR259C RPT4 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization
0.104 1.31E-9 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.104 1.53E-9 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.104 1.76E-9 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 1.96E-9 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.103 2.30E-9 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.102 2.63E-9 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.102 3.75E-9 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.101 3.99E-9 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.101 4.36E-9 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.100 7.34E-9 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.098 1.26E-8 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases