YOL056W / GPM3

Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL056W / GPM3

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:-3.94|P-value:1.89E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.30|P-value:3.14E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.71|P-value:5.32E-7 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.29|P-value:4.43E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.67|P-value:6.18E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.36|P-value:2.14E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.40|P-value:1.82E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.02|P-value:8.91E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.41|P-value:1.76E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-2.95|P-value:9.72E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-2.99|P-value:8.50E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.01|P-value:9.19E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.71|P-value:5.23E-7 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.17|P-value:5.18E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.08|P-value:6.12E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.00|P-value:8.33E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.45|P-value:1.96E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.83|P-value:3.66E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.61|P-value:9.20E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.66|P-value:7.47E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.94|P-value:1.84E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.33|P-value:2.88E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.60|P-value:8.22E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-2.95|P-value:9.75E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.99|P-value:1.50E-5 ID:SGTC_2123|Compound:5259487|FD-Score:5.70|P-value:1.67E-9 ID:SGTC_2158|Compound:5657123|FD-Score:-2.98|P-value:8.96E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.04|P-value:7.09E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.32|P-value:1.71E-8 ID:SGTC_2285|Compound:7945142|FD-Score:-3.86|P-value:2.65E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.99|P-value:9.16E-8 ID:SGTC_2337|Compound:9009472|FD-Score:-5.16|P-value:3.40E-8 ID:SGTC_2338|Compound:7999974|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.35|P-value:2.66E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.41|P-value:2.07E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-2.97|P-value:9.15E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.88|P-value:5.47E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.30|P-value:4.17E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.53|P-value:1.31E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.73|P-value:5.67E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.14|P-value:7.45E-6 ID:SGTC_2970|Compound:9090938|FD-Score:5.90|P-value:4.59E-10 ID:SGTC_2971|Compound:9092186|FD-Score:3.19|P-value:4.79E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.75|P-value:5.23E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.06|P-value:7.72E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.98|P-value:8.84E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.94|P-value:1.89E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.30|P-value:3.14E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.71|P-value:5.32E-7 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.29|P-value:4.43E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.67|P-value:6.18E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.36|P-value:2.14E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.40|P-value:1.82E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.02|P-value:8.91E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:1.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.41|P-value:1.76E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-2.95|P-value:9.72E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-2.99|P-value:8.50E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.01|P-value:9.19E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.71|P-value:5.23E-7 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.17|P-value:5.18E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.08|P-value:6.12E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.00|P-value:8.33E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.45|P-value:1.96E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.83|P-value:3.66E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.61|P-value:9.20E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.66|P-value:7.47E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.21|P-value:4.43E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.94|P-value:1.84E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.13|P-value:6.03E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.33|P-value:2.88E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.60|P-value:8.22E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-2.95|P-value:9.75E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.99|P-value:1.50E-5 ID:SGTC_2123|Compound:5259487|FD-Score:5.70|P-value:1.67E-9 ID:SGTC_2158|Compound:5657123|FD-Score:-2.98|P-value:8.96E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.04|P-value:7.09E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.32|P-value:1.71E-8 ID:SGTC_2285|Compound:7945142|FD-Score:-3.86|P-value:2.65E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-4.99|P-value:9.16E-8 ID:SGTC_2337|Compound:9009472|FD-Score:-5.16|P-value:3.40E-8 ID:SGTC_2338|Compound:7999974|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.35|P-value:2.66E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.41|P-value:2.07E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-2.97|P-value:9.15E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.88|P-value:5.47E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.30|P-value:4.17E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.53|P-value:1.31E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.73|P-value:5.67E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.14|P-value:7.45E-6 ID:SGTC_2970|Compound:9090938|FD-Score:5.90|P-value:4.59E-10 ID:SGTC_2971|Compound:9092186|FD-Score:3.19|P-value:4.79E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.75|P-value:5.23E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.06|P-value:7.72E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.98|P-value:8.84E-4

Top fitness defect scores for YOL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2970 9090938 5.90 41.9 µM 4.59E-10 RNA processing & uracil transport 4 1.80E-9
2 SGTC_2565 isoliquiritigenin 5.88 100.0 µM 5.47E-10 10 2.11E-9
3 SGTC_2123 5259487 5.70 200.0 µM 1.67E-9 3 5.94E-9
4 SGTC_2259 7964009 5.32 200.0 µM 1.71E-8 superoxide 16 5.14E-8
5 SGTC_1146 3579-1023 4.71 7.0 µM 5.23E-7 6 1.23E-6
6 SGTC_114 0364-0001 4.71 490.3 µM 5.32E-7 22 1.25E-6
7 SGTC_1244 0416-0015 4.45 52.5 µM 1.96E-6 ERG2 19 4.22E-6
8 SGTC_2566 crystal violet carbinol 4.30 226.0 nM 4.17E-6 33 8.49E-6
9 SGTC_405 ebelactone b 4.29 50.0 µM 4.43E-6 12 8.97E-6
10 SGTC_1245 0418-0076 3.83 17.2 µM 3.66E-5 ERG2 34 6.40E-5
11 SGTC_2973 9094665 3.75 18.0 µM 5.23E-5 NEO1 36 8.92E-5
12 SGTC_2620 irigenin 3.73 100.0 µM 5.67E-5 46 9.63E-5
13 SGTC_1357 1503-1303 3.66 39.5 µM 7.47E-5 42 1.24E-4
14 SGTC_1331 1472-0049 3.61 76.2 µM 9.20E-5 31 1.51E-4
15 SGTC_2618 avocadyne 3.53 43.4 µM 1.31E-4 45 2.10E-4
16 SGTC_2371 9071574 3.52 200.0 µM 1.36E-4 21 2.17E-4
17 SGTC_930 2810-3379 3.49 265.0 µM 1.53E-4 21 2.43E-4
18 SGTC_1936 st074407 3.49 74.3 µM 1.55E-4 DNA damage response 54 2.45E-4
19 SGTC_2624 nerol 3.47 100.0 µM 1.64E-4 19 2.58E-4
20 SGTC_928 2764-0428 3.47 58.7 µM 1.65E-4 cell wall 79 2.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 8.22E-14 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.101 4.15E-9 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.097 2.04E-8 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 5.36E-7 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.085 9.33E-7 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.080 3.58E-6 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.080 3.67E-6 YMR307W GAS1 hom Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
0.079 4.37E-6 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
0.079 4.70E-6 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.079 5.29E-6 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.077 7.04E-6 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.077 7.08E-6 YLR297W YLR297W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication
0.076 1.01E-5 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.075 1.22E-5 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
0.072 2.76E-5 YJR045C SSC1 het Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication