YOL060C / MAM3

Protein required for normal mitochondrial morphology, has similarity to hemolysins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL060C / MAM3

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:3.56|P-value:9.64E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.23|P-value:4.69E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.02|P-value:8.40E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.84|P-value:2.93E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.13|P-value:5.11E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.20|P-value:3.95E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.38|P-value:1.98E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.27|P-value:3.89E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:2.97|P-value:9.21E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:6.77|P-value:7.51E-13 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.31|P-value:2.91E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.52|P-value:1.12E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-4.40|P-value:2.36E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.01|P-value:8.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.80|P-value:3.77E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.48|P-value:1.34E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-9.74|P-value:1.52E-24 ID:SGTC_2241|Compound:6772625|FD-Score:-7.31|P-value:1.32E-14 ID:SGTC_2245|Compound:6637752|FD-Score:4.13|P-value:7.61E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.74|P-value:5.01E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.35|P-value:1.25E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.07|P-value:6.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.12|P-value:7.40E-22 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.15|P-value:5.24E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.06|P-value:7.35E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.40|P-value:2.28E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:4.01|P-value:1.35E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:6.49|P-value:5.81E-12 ID:SGTC_2782|Compound:7736369|FD-Score:-3.62|P-value:8.26E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.63|P-value:6.18E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-3.63|P-value:8.03E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.05|P-value:7.71E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-5.20|P-value:3.14E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-5.17|P-value:3.74E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-6.02|P-value:1.77E-10 ID:SGTC_2923|Compound:7992654|FD-Score:-3.26|P-value:3.48E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.13|P-value:5.22E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.84|P-value:2.94E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.81|P-value:2.37E-7 ID:SGTC_2991|Compound:9074669|FD-Score:3.57|P-value:9.39E-5 ID:SGTC_2995|Compound:9067767|FD-Score:5.19|P-value:2.77E-8 ID:SGTC_3220|Compound:9131269|FD-Score:-4.10|P-value:9.70E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.56|P-value:9.64E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.23|P-value:4.69E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.02|P-value:8.40E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.84|P-value:2.93E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.13|P-value:5.11E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.20|P-value:3.95E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.38|P-value:1.98E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:4.27|P-value:3.89E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:2.97|P-value:9.21E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:6.77|P-value:7.51E-13 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.31|P-value:2.91E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.52|P-value:1.12E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.05|P-value:7.08E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-4.40|P-value:2.36E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.01|P-value:8.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.80|P-value:3.77E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.48|P-value:1.34E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-9.74|P-value:1.52E-24 ID:SGTC_2241|Compound:6772625|FD-Score:-7.31|P-value:1.32E-14 ID:SGTC_2245|Compound:6637752|FD-Score:4.13|P-value:7.61E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.74|P-value:5.01E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.35|P-value:1.25E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.07|P-value:6.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.12|P-value:7.40E-22 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.15|P-value:5.24E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.06|P-value:7.35E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.40|P-value:2.28E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:4.01|P-value:1.35E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:6.49|P-value:5.81E-12 ID:SGTC_2782|Compound:7736369|FD-Score:-3.62|P-value:8.26E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.63|P-value:6.18E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-3.63|P-value:8.03E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.05|P-value:7.71E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-5.20|P-value:3.14E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-5.17|P-value:3.74E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-6.02|P-value:1.77E-10 ID:SGTC_2923|Compound:7992654|FD-Score:-3.26|P-value:3.48E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.13|P-value:5.22E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.84|P-value:2.94E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.81|P-value:2.37E-7 ID:SGTC_2991|Compound:9074669|FD-Score:3.57|P-value:9.39E-5 ID:SGTC_2995|Compound:9067767|FD-Score:5.19|P-value:2.77E-8 ID:SGTC_3220|Compound:9131269|FD-Score:-4.10|P-value:9.70E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.16|P-value:4.70E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.53|P-value:1.11E-4

Top fitness defect scores for YOL060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.12 100.0 µM 7.40E-22 redox potentiating 82 3.60E-20
2 SGTC_936 3005-4620 6.77 401.0 µM 7.51E-13 3 6.64E-12
3 SGTC_2770 toltrazuril 6.49 17.5 µM 5.81E-12 4 4.34E-11
4 SGTC_2995 9067767 5.19 71.4 µM 2.77E-8 7 1.03E-7
5 SGTC_2989 9073649 4.81 71.4 µM 2.37E-7 14 7.42E-7
6 SGTC_2783 7738165 4.63 71.4 µM 6.18E-7 16 1.79E-6
7 SGTC_701 4424-0219 4.27 185.0 µM 3.89E-6 calcium & mitochondrial duress 18 9.71E-6
8 SGTC_58 0957-0393 4.23 9.0 µM 4.69E-6 cell wall 349 1.15E-5
9 SGTC_2245 6637752 4.13 200.0 µM 7.61E-6 15 1.80E-5
10 SGTC_2769 toremifene 4.01 3.7 µM 1.35E-5 22 3.05E-5
11 SGTC_172 1112-0046 3.84 2.6 µM 2.93E-5 NEO1 37 6.21E-5
12 SGTC_2974 9094440 3.84 9.7 µM 2.94E-5 ergosterol biosynthesis 49 6.22E-5
13 SGTC_2991 9074669 3.57 71.4 µM 9.39E-5 azole & statin 79 1.81E-4
14 SGTC_57 miconazole 3.56 162.5 nM 9.64E-5 ergosterol depletion effects on membrane 35 1.85E-4
15 SGTC_3309 9129340 3.53 25.8 µM 1.11E-4 25 2.12E-4
16 SGTC_1302 1159-0335 3.52 255.0 µM 1.12E-4 24 2.12E-4
17 SGTC_2002 4023503 3.48 131.0 µM 1.34E-4 mitochondrial processes 55 2.52E-4
18 SGTC_457 grayanotoxin iii 3.38 135.0 µM 1.98E-4 107 3.60E-4
19 SGTC_2925 9010536 3.22 32.5 µM 3.70E-4 azole & statin 82 6.40E-4
20 SGTC_311 1315-0136 3.20 58.0 µM 3.95E-4 34 6.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 3.54E-55 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.217 4.50E-37 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.216 6.90E-37 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.210 6.34E-35 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.201 1.00E-31 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.200 9.54E-32 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.200 1.04E-31 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.192 4.32E-29 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.185 2.79E-27 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.183 1.06E-26 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.176 1.26E-24 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.172 9.59E-24 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.172 1.14E-23 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.171 1.61E-23 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.170 3.21E-23 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress