YOL062C / APM4

Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL062C / APM4

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.24|P-value:1.80E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.94|P-value:6.20E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:2.94|P-value:6.04E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.93|P-value:6.28E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.12|P-value:2.87E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:2.88|P-value:7.72E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.05|P-value:4.03E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.92|P-value:6.68E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:2.96|P-value:5.54E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.76|P-value:1.78E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.71|P-value:1.01E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.09|P-value:3.18E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.81|P-value:9.81E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.18|P-value:2.37E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.91|P-value:6.82E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:5.16|P-value:6.71E-9 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.09|P-value:3.15E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-4.12|P-value:2.64E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-2.85|P-value:8.05E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.63|P-value:3.28E-5 ID:SGTC_1796|Compound:st049173|FD-Score:2.85|P-value:8.50E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-2.97|P-value:5.07E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.94|P-value:7.33E-6 ID:SGTC_2019|Compound:4016004|FD-Score:3.74|P-value:1.93E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.49|P-value:6.23E-5 ID:SGTC_2075|Compound:5212009|FD-Score:2.90|P-value:7.10E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.07|P-value:3.62E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.59|P-value:3.86E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.33|P-value:1.23E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.08|P-value:3.55E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.80|P-value:9.97E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.98|P-value:5.91E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.67|P-value:2.54E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.69|P-value:2.45E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.60|P-value:2.04E-7 ID:SGTC_2704|Compound:st078022|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.88|P-value:7.73E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-5.00|P-value:1.65E-8 ID:SGTC_2786|Compound:7743617|FD-Score:-3.23|P-value:1.80E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.69|P-value:1.87E-10 ID:SGTC_2790|Compound:5423970|FD-Score:-3.93|P-value:7.19E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.45|P-value:4.81E-7 ID:SGTC_2873|Compound:9040596|FD-Score:-3.24|P-value:1.70E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.92|P-value:7.68E-6 ID:SGTC_2982|Compound:9019404|FD-Score:2.99|P-value:5.06E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.40|P-value:8.96E-5 ID:SGTC_3032|Compound:9089427|FD-Score:2.83|P-value:9.32E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.57|P-value:4.09E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.67|P-value:1.36E-7 ID:SGTC_3319|Compound:9138450|FD-Score:3.87|P-value:1.03E-5 ID:SGTC_3320|Compound:9137005|FD-Score:4.34|P-value:8.98E-7 ID:SGTC_3326|Compound:9140064|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.96|P-value:5.99E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-6.11|P-value:7.78E-12 ID:SGTC_8|Compound:0354-0001|FD-Score:3.24|P-value:1.80E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.94|P-value:6.20E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:2.94|P-value:6.04E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.93|P-value:6.28E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.12|P-value:2.87E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:2.88|P-value:7.72E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.05|P-value:4.03E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.92|P-value:6.68E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:2.96|P-value:5.54E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.76|P-value:1.78E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.71|P-value:1.01E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.09|P-value:3.18E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.81|P-value:9.81E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.18|P-value:2.37E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.91|P-value:6.82E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:5.16|P-value:6.71E-9 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-3.09|P-value:3.15E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-4.12|P-value:2.64E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-2.85|P-value:8.05E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.63|P-value:3.28E-5 ID:SGTC_1796|Compound:st049173|FD-Score:2.85|P-value:8.50E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-2.97|P-value:5.07E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.03|P-value:4.23E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.94|P-value:7.33E-6 ID:SGTC_2019|Compound:4016004|FD-Score:3.74|P-value:1.93E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.49|P-value:6.23E-5 ID:SGTC_2075|Compound:5212009|FD-Score:2.90|P-value:7.10E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.07|P-value:3.62E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.59|P-value:3.86E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.33|P-value:1.23E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.08|P-value:3.55E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.80|P-value:9.97E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.98|P-value:5.91E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.67|P-value:2.54E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.69|P-value:2.45E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.60|P-value:2.04E-7 ID:SGTC_2704|Compound:st078022|FD-Score:3.22|P-value:1.96E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.88|P-value:7.73E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-5.00|P-value:1.65E-8 ID:SGTC_2786|Compound:7743617|FD-Score:-3.23|P-value:1.80E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.69|P-value:1.87E-10 ID:SGTC_2790|Compound:5423970|FD-Score:-3.93|P-value:7.19E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.45|P-value:4.81E-7 ID:SGTC_2873|Compound:9040596|FD-Score:-3.24|P-value:1.70E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.92|P-value:7.68E-6 ID:SGTC_2982|Compound:9019404|FD-Score:2.99|P-value:5.06E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.40|P-value:8.96E-5 ID:SGTC_3032|Compound:9089427|FD-Score:2.83|P-value:9.32E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.57|P-value:4.09E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.67|P-value:1.36E-7 ID:SGTC_3319|Compound:9138450|FD-Score:3.87|P-value:1.03E-5 ID:SGTC_3320|Compound:9137005|FD-Score:4.34|P-value:8.98E-7 ID:SGTC_3326|Compound:9140064|FD-Score:3.06|P-value:3.73E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.96|P-value:5.99E-6 ID:SGTC_3334|Compound:9142812|FD-Score:-6.11|P-value:7.78E-12

Top fitness defect scores for YOL062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2789 5281112 5.69 71.4 µM 1.87E-10 8 6.41E-9
2 SGTC_1578 josamycin 5.16 24.2 µM 6.71E-9 6 1.24E-7
3 SGTC_3145 9085516 4.67 49.5 µM 1.36E-7 fatty acid desaturase (OLE1) 13 1.51E-6
4 SGTC_2514 salinomycin 4.60 42.7 µM 2.04E-7 28 2.11E-6
5 SGTC_2821 7996764 4.45 71.4 µM 4.81E-7 26 4.29E-6
6 SGTC_3320 9137005 4.34 35.1 µM 8.98E-7 endomembrane recycling 10 7.20E-6
7 SGTC_503 tyrphostin 8 4.12 294.0 µM 2.87E-6 TSC3-RPN4 19 1.89E-5
8 SGTC_2488 5268135 3.98 45.7 µM 5.91E-6 52 3.45E-5
9 SGTC_2015 5119600 3.94 184.0 µM 7.33E-6 31 4.12E-5
10 SGTC_3319 9138450 3.87 16.8 µM 1.03E-5 23 5.47E-5
11 SGTC_1179 1021-1431 3.76 9.3 µM 1.78E-5 50 8.62E-5
12 SGTC_2019 4016004 3.74 108.0 µM 1.93E-5 37 9.21E-5
13 SGTC_2511 berberine 3.69 10.5 µM 2.45E-5 60S ribosome export 24 1.13E-4
14 SGTC_1774 st048371 3.63 48.5 µM 3.28E-5 RNA processing & uracil transport 28 1.43E-4
15 SGTC_2226 7298446 3.59 200.0 µM 3.86E-5 6 1.64E-4
16 SGTC_2067 5224629 3.49 34.1 µM 6.23E-5 37 2.45E-4
17 SGTC_3015 9080845 3.40 49.5 µM 8.96E-5 18 3.31E-4
18 SGTC_2255 7941087 3.33 197.4 µM 1.23E-4 51 4.31E-4
19 SGTC_482 fipronil 3.32 114.0 µM 1.29E-4 8 4.47E-4
20 SGTC_8 0354-0001 3.24 70.0 µM 1.80E-4 125 5.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.69E-12 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.102 2.72E-9 YFL054C_p YFL054C_p hom Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
0.102 2.99E-9 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.098 1.44E-8 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.096 3.04E-8 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.087 4.34E-7 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.087 4.82E-7 YER085C_p YER085C_p hom Putative protein of unknown function
0.081 2.74E-6 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.081 2.92E-6 YPR015C_p YPR015C_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.077 8.94E-6 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.072 2.82E-5 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.072 3.14E-5 YNR048W YNR048W hom Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication
0.071 3.53E-5 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.070 4.53E-5 YLR122C_d YLR122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
0.070 4.76E-5 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway