YOL063C / CRT10

Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL063C / CRT10

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:2.95|P-value:9.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.19|P-value:4.30E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.32|P-value:2.62E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.00|P-value:8.03E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.45|P-value:1.59E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.18|P-value:4.53E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.33|P-value:2.39E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.13|P-value:8.29E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:3.06|P-value:6.63E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.27|P-value:3.27E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.07|P-value:6.23E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.20|P-value:5.35E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.99|P-value:8.49E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.76|P-value:3.06E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.40|P-value:2.19E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:4.52|P-value:1.06E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.90|P-value:2.37E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.16|P-value:6.90E-6 ID:SGTC_1728|Compound:st035614|FD-Score:4.09|P-value:8.85E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.86|P-value:2.58E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.25|P-value:2.05E-8 ID:SGTC_1746|Compound:st038117|FD-Score:-3.22|P-value:3.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:2.96|P-value:9.44E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.69|P-value:1.26E-9 ID:SGTC_1778|Compound:st046819|FD-Score:-3.34|P-value:2.45E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-2.98|P-value:9.45E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.86|P-value:2.80E-5 ID:SGTC_1837|Compound:st055472|FD-Score:-4.19|P-value:6.17E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.02|P-value:7.74E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.83|P-value:2.94E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.64|P-value:6.62E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.74|P-value:4.33E-5 ID:SGTC_2045|Compound:5106652|FD-Score:3.49|P-value:1.26E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.78|P-value:3.67E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.01|P-value:7.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.56|P-value:9.32E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.09|P-value:5.90E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.62|P-value:7.99E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.65|P-value:6.51E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.66|P-value:6.16E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.20|P-value:4.17E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.63|P-value:6.97E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.12|P-value:5.71E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.07|P-value:5.32E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.14|P-value:4.86E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.36|P-value:2.63E-6 ID:SGTC_2881|Compound:9058953|FD-Score:-3.31|P-value:2.77E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.01|P-value:7.91E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.63|P-value:7.60E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.80|P-value:3.33E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.79|P-value:3.50E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.50|P-value:1.17E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.11|P-value:5.48E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.06|P-value:6.67E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:2.95|P-value:9.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.19|P-value:4.30E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.32|P-value:2.62E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.00|P-value:8.03E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.45|P-value:1.59E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.18|P-value:4.53E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.33|P-value:2.39E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.13|P-value:8.29E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:3.06|P-value:6.63E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.27|P-value:3.27E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.07|P-value:6.23E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.20|P-value:5.35E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.99|P-value:8.49E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.76|P-value:3.06E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.40|P-value:2.19E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:4.52|P-value:1.06E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.90|P-value:2.37E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.16|P-value:6.90E-6 ID:SGTC_1728|Compound:st035614|FD-Score:4.09|P-value:8.85E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.86|P-value:2.58E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.25|P-value:2.05E-8 ID:SGTC_1746|Compound:st038117|FD-Score:-3.22|P-value:3.95E-4 ID:SGTC_1748|Compound:st037455|FD-Score:2.96|P-value:9.44E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.69|P-value:1.26E-9 ID:SGTC_1778|Compound:st046819|FD-Score:-3.34|P-value:2.45E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-2.98|P-value:9.45E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.86|P-value:2.80E-5 ID:SGTC_1837|Compound:st055472|FD-Score:-4.19|P-value:6.17E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.02|P-value:7.74E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.83|P-value:2.94E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.64|P-value:6.62E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.74|P-value:4.33E-5 ID:SGTC_2045|Compound:5106652|FD-Score:3.49|P-value:1.26E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.78|P-value:3.67E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.01|P-value:7.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.56|P-value:9.32E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.09|P-value:5.90E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.62|P-value:7.99E-5 ID:SGTC_2373|Compound:9071805|FD-Score:3.65|P-value:6.51E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.66|P-value:6.16E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.20|P-value:4.17E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.63|P-value:6.97E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.17|P-value:4.31E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.12|P-value:5.71E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.07|P-value:5.32E-8 ID:SGTC_2707|Compound:st078556|FD-Score:3.14|P-value:4.86E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.36|P-value:2.63E-6 ID:SGTC_2881|Compound:9058953|FD-Score:-3.31|P-value:2.77E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.01|P-value:7.91E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.63|P-value:7.60E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.32|P-value:2.67E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.80|P-value:3.33E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.79|P-value:3.50E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.50|P-value:1.17E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.11|P-value:5.48E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.06|P-value:6.67E-4

Top fitness defect scores for YOL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1775 st081588 5.69 35.2 µM 1.26E-9 60S ribosome export 6 6.52E-9
2 SGTC_2638 epoxomicin 5.07 18.0 µM 5.32E-8 9 1.99E-7
3 SGTC_1257 0669-0121 4.76 16.0 µM 3.06E-7 12 9.88E-7
4 SGTC_1529 apigenin 4.52 74.0 µM 1.06E-6 20 3.08E-6
5 SGTC_3188 9110789 4.50 49.5 µM 1.17E-6 iron homeostasis 12 3.35E-6
6 SGTC_1134 3477-0009 4.20 42.5 µM 5.35E-6 41 1.35E-5
7 SGTC_1728 st035614 4.09 33.8 µM 8.85E-6 39 2.14E-5
8 SGTC_1734 st037168 3.86 69.4 µM 2.58E-5 27 5.71E-5
9 SGTC_1909 st060837 3.83 51.5 µM 2.94E-5 56 6.42E-5
10 SGTC_3137 9097352 3.80 49.5 µM 3.33E-5 44 7.19E-5
11 SGTC_3146 9095609 3.79 49.5 µM 3.50E-5 17 7.54E-5
12 SGTC_2055 5235184 3.78 200.0 µM 3.67E-5 ERG2 42 7.87E-5
13 SGTC_1970 st070122 3.74 35.8 µM 4.33E-5 TSC3-RPN4 32 9.15E-5
14 SGTC_2428 5615643 3.66 7.8 µM 6.16E-5 36 1.26E-4
15 SGTC_2373 9071805 3.65 200.0 µM 6.51E-5 20 1.33E-4
16 SGTC_1951 sophoraflavanone G 3.64 9.2 µM 6.62E-5 RNA processing & uracil transport 36 1.35E-4
17 SGTC_2604 4'-hydroxychalcone 3.63 11.3 µM 6.97E-5 49 1.42E-4
18 SGTC_2307 7538926 3.56 6.3 µM 9.32E-5 54 1.85E-4
19 SGTC_2045 5106652 3.49 78.0 µM 1.26E-4 22 2.44E-4
20 SGTC_188 3229-0966 3.36 278.5 µM 2.15E-4 52 3.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.20E-7 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.089 2.79E-7 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.088 3.71E-7 YCL059C KRR1 het Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
0.083 1.33E-6 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.083 1.43E-6 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.079 4.11E-6 YGL158W RCK1 hom Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
0.079 4.82E-6 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.078 5.38E-6 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.074 1.77E-5 YOL031C SIL1 hom Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.074 1.87E-5 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.072 2.63E-5 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.072 2.72E-5 YKL129C MYO3 hom One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.069 6.76E-5 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.068 7.75E-5 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.067 9.29E-5 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore