YOL067C / RTG1

Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL067C / RTG1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:4.33|P-value:5.21E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.60|P-value:5.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.93|P-value:4.98E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.59|P-value:1.80E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.18|P-value:8.33E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.56|P-value:3.05E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:5.22|P-value:1.42E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.65|P-value:1.54E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:4.38|P-value:4.40E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.54|P-value:7.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.88|P-value:2.58E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.92|P-value:2.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.70|P-value:1.28E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.26|P-value:6.80E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.52|P-value:2.55E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.64|P-value:1.45E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-5.85|P-value:6.85E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-5.96|P-value:4.06E-8 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.56|P-value:1.96E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.62|P-value:5.42E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.80|P-value:3.37E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.65|P-value:5.46E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.03|P-value:3.31E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.98|P-value:1.81E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.35|P-value:2.12E-11 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.10|P-value:1.22E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.95|P-value:2.05E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.65|P-value:5.36E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.52|P-value:7.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.27|P-value:5.98E-5 ID:SGTC_1766|Compound:st045414|FD-Score:4.00|P-value:1.69E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.90|P-value:2.22E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.84|P-value:5.47E-19 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.89|P-value:3.31E-10 ID:SGTC_1977|Compound:st070720|FD-Score:3.57|P-value:6.93E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.45|P-value:9.45E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.59|P-value:6.48E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.55|P-value:6.90E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.85|P-value:2.79E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.53|P-value:7.82E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.79|P-value:8.70E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.45|P-value:9.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.62|P-value:5.46E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.06|P-value:1.38E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.52|P-value:7.52E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.67|P-value:5.06E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.54|P-value:2.39E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.93|P-value:2.14E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.50|P-value:8.62E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.47|P-value:9.38E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.42|P-value:3.44E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.63|P-value:5.82E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.17|P-value:9.35E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.96|P-value:4.39E-6 ID:SGTC_2976|Compound:9009005|FD-Score:-7.24|P-value:3.56E-11 ID:SGTC_2977|Compound:9011197|FD-Score:-4.04|P-value:1.36E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-5.54|P-value:3.01E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.18|P-value:8.40E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.60|P-value:5.82E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.95|P-value:4.55E-6 ID:SGTC_3106|Compound:9121286|FD-Score:3.50|P-value:8.67E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.80|P-value:8.68E-6 ID:SGTC_3111|Compound:9122088|FD-Score:-3.66|P-value:4.86E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.70|P-value:4.65E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.14|P-value:1.04E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.44|P-value:3.49E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-3.70|P-value:4.25E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.20|P-value:8.44E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.33|P-value:5.21E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.60|P-value:5.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.93|P-value:4.98E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.59|P-value:1.80E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-4.18|P-value:8.33E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.56|P-value:3.05E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:5.22|P-value:1.42E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.65|P-value:1.54E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:4.38|P-value:4.40E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.54|P-value:7.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.88|P-value:2.58E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.92|P-value:2.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.70|P-value:1.28E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.26|P-value:6.80E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.52|P-value:2.55E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.64|P-value:1.45E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-5.85|P-value:6.85E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-5.96|P-value:4.06E-8 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.56|P-value:1.96E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.62|P-value:5.42E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.80|P-value:3.37E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.65|P-value:5.46E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.03|P-value:3.31E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.98|P-value:1.81E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.35|P-value:2.12E-11 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.10|P-value:1.22E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.95|P-value:2.05E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.65|P-value:5.36E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.52|P-value:7.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.27|P-value:5.98E-5 ID:SGTC_1766|Compound:st045414|FD-Score:4.00|P-value:1.69E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.90|P-value:2.22E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.84|P-value:5.47E-19 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.89|P-value:3.31E-10 ID:SGTC_1977|Compound:st070720|FD-Score:3.57|P-value:6.93E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.45|P-value:9.45E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.59|P-value:6.48E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.55|P-value:6.90E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.85|P-value:2.79E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.53|P-value:7.82E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.79|P-value:8.70E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.45|P-value:9.39E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.62|P-value:5.46E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.06|P-value:1.38E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.52|P-value:7.52E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.67|P-value:5.06E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.54|P-value:2.39E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.93|P-value:2.14E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.50|P-value:8.62E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.47|P-value:9.38E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.42|P-value:3.44E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.63|P-value:5.82E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.17|P-value:9.35E-5 ID:SGTC_2952|Compound:9073731|FD-Score:4.96|P-value:4.39E-6 ID:SGTC_2976|Compound:9009005|FD-Score:-7.24|P-value:3.56E-11 ID:SGTC_2977|Compound:9011197|FD-Score:-4.04|P-value:1.36E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-5.54|P-value:3.01E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.18|P-value:8.40E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.60|P-value:5.82E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.95|P-value:4.55E-6 ID:SGTC_3106|Compound:9121286|FD-Score:3.50|P-value:8.67E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.80|P-value:8.68E-6 ID:SGTC_3111|Compound:9122088|FD-Score:-3.66|P-value:4.86E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.70|P-value:4.65E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.14|P-value:1.04E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.44|P-value:3.49E-5 ID:SGTC_3260|Compound:9137109|FD-Score:-3.70|P-value:4.25E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.20|P-value:8.44E-5

Top fitness defect scores for YOL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 9.84 4.0 nM 5.47E-19 40 3.95E-23
2 SGTC_1353 1498-1206 7.35 8.1 µM 2.12E-11 mitochondrial response to ROS 6 9.59E-14
3 SGTC_1877 wortmannin 6.89 25.0 µM 3.31E-10 35 2.86E-12
4 SGTC_210 3551-0445 5.56 56.8 µM 3.05E-7 28 1.31E-8
5 SGTC_383 2324-0395 5.22 7.4 µM 1.42E-6 azole & statin 20 8.75E-8
6 SGTC_1310 1188-0297 5.03 994.0 nM 3.31E-6 azole & statin 14 2.48E-7
7 SGTC_2952 9073731 4.96 13.8 µM 4.39E-6 tubulin folding & SWR complex 16 3.51E-7
8 SGTC_3102 9121669 4.95 49.5 µM 4.55E-6 2 3.67E-7
9 SGTC_141 0443-0274 4.93 32.3 µM 4.98E-6 mitochondrial response to ROS 22 4.10E-7
10 SGTC_3110 9122132 4.80 49.5 µM 8.68E-6 redox potentiating 9 8.13E-7
11 SGTC_2166 5933061 4.79 31.5 µM 8.70E-6 tubulin folding & SWR complex 22 8.15E-7
12 SGTC_690 glyoxal 4.70 20.3 µM 1.28E-5 62 1.31E-6
13 SGTC_393 acivicin 4.65 6.2 µM 1.54E-5 14 1.65E-6
14 SGTC_2679 rapamycin 4.54 1.0 nM 2.39E-5 115 2.82E-6
15 SGTC_778 3456-2434 4.52 196.0 µM 2.55E-5 mitochondrial response to ROS 57 3.07E-6
16 SGTC_3189 9110682 4.44 49.5 µM 3.49E-5 25 4.50E-6
17 SGTC_428 3448-4153 4.38 16.5 µM 4.40E-5 TSC3-RPN4 21 5.99E-6
18 SGTC_100 0086-0128 4.33 49.6 µM 5.21E-5 copper-dependent oxidative stress 34 7.38E-6
19 SGTC_736 0958-0254 4.26 92.6 µM 6.80E-5 Golgi 23 1.02E-5
20 SGTC_3352 9151559 4.20 45.6 µM 8.44E-5 7 1.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.363 4.72E-105 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.266 1.71E-55 YBL103C RTG3 hom Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
0.197 1.04E-30 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.166 3.77E-22 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.164 1.74E-21 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.159 2.62E-20 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.158 3.97E-20 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.157 4.73E-20 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.154 2.99E-19 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.148 6.09E-18 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.144 4.42E-17 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.143 1.05E-16 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.141 3.06E-16 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.140 4.19E-16 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.139 5.38E-16 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data