YOL068C / HST1

NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL068C / HST1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.88|P-value:9.75E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.05|P-value:5.05E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:4.44|P-value:1.01E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.40|P-value:5.46E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.74|P-value:1.66E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.95|P-value:7.43E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.39|P-value:5.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-11.60|P-value:6.95E-29 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.43|P-value:9.47E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.34|P-value:1.49E-7 ID:SGTC_430|Compound:0958-0115|FD-Score:3.30|P-value:7.78E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.36|P-value:6.19E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.50|P-value:3.94E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.26|P-value:8.88E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.52|P-value:3.62E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.53|P-value:3.49E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.40|P-value:5.57E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.27|P-value:8.60E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.53|P-value:3.49E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.58|P-value:2.98E-4 ID:SGTC_1664|Compound:st014217|FD-Score:4.13|P-value:3.67E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.21|P-value:2.86E-7 ID:SGTC_1707|Compound:st032323|FD-Score:4.58|P-value:5.53E-6 ID:SGTC_1744|Compound:st037937|FD-Score:4.73|P-value:2.90E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.82|P-value:1.85E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.06|P-value:4.89E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-4.30|P-value:1.83E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1886|Compound:st057356|FD-Score:7.96|P-value:1.12E-14 ID:SGTC_1893|Compound:st059353|FD-Score:-5.00|P-value:7.84E-7 ID:SGTC_1896|Compound:st058441|FD-Score:-3.94|P-value:7.82E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.92|P-value:8.39E-5 ID:SGTC_2237|Compound:6667747|FD-Score:3.98|P-value:6.75E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.69|P-value:2.03E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.40|P-value:5.60E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.43|P-value:9.38E-8 ID:SGTC_2338|Compound:7999974|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.51|P-value:3.78E-4 ID:SGTC_2483|Compound:5729050|FD-Score:5.62|P-value:3.43E-8 ID:SGTC_2486|Compound:5283202|FD-Score:-3.41|P-value:5.28E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.45|P-value:4.58E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:5.55|P-value:5.17E-8 ID:SGTC_2570|Compound:licareol|FD-Score:3.90|P-value:9.16E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.82|P-value:1.89E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.40|P-value:5.50E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:6.70E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.24|P-value:9.37E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.35|P-value:6.46E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.46|P-value:4.52E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:5.86|P-value:9.36E-9 ID:SGTC_2913|Compound:7966556|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.80|P-value:1.32E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.26|P-value:2.23E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.88|P-value:9.96E-5 ID:SGTC_3032|Compound:9089427|FD-Score:5.25|P-value:2.42E-7 ID:SGTC_3072|Compound:9116419|FD-Score:-3.96|P-value:7.28E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.46|P-value:9.48E-6 ID:SGTC_3170|Compound:9103054|FD-Score:4.07|P-value:4.69E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.09|P-value:4.31E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.88|P-value:9.75E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.05|P-value:5.05E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:4.44|P-value:1.01E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.40|P-value:5.46E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.74|P-value:1.66E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.95|P-value:7.43E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.39|P-value:5.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-11.60|P-value:6.95E-29 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.43|P-value:9.47E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.34|P-value:1.49E-7 ID:SGTC_430|Compound:0958-0115|FD-Score:3.30|P-value:7.78E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.36|P-value:6.19E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.50|P-value:3.94E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.26|P-value:8.88E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.52|P-value:3.62E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.53|P-value:3.49E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.40|P-value:5.57E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.27|P-value:8.60E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.74|P-value:1.68E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.65|P-value:2.30E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.53|P-value:3.49E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.58|P-value:2.98E-4 ID:SGTC_1664|Compound:st014217|FD-Score:4.13|P-value:3.67E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.21|P-value:2.86E-7 ID:SGTC_1707|Compound:st032323|FD-Score:4.58|P-value:5.53E-6 ID:SGTC_1744|Compound:st037937|FD-Score:4.73|P-value:2.90E-6 ID:SGTC_1745|Compound:st081495|FD-Score:-4.82|P-value:1.85E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.06|P-value:4.89E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-4.30|P-value:1.83E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1886|Compound:st057356|FD-Score:7.96|P-value:1.12E-14 ID:SGTC_1893|Compound:st059353|FD-Score:-5.00|P-value:7.84E-7 ID:SGTC_1896|Compound:st058441|FD-Score:-3.94|P-value:7.82E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.71|P-value:1.89E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.92|P-value:8.39E-5 ID:SGTC_2237|Compound:6667747|FD-Score:3.98|P-value:6.75E-5 ID:SGTC_2238|Compound:6671620|FD-Score:3.69|P-value:2.03E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.40|P-value:5.60E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.43|P-value:9.38E-8 ID:SGTC_2338|Compound:7999974|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.51|P-value:3.78E-4 ID:SGTC_2483|Compound:5729050|FD-Score:5.62|P-value:3.43E-8 ID:SGTC_2486|Compound:5283202|FD-Score:-3.41|P-value:5.28E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.45|P-value:4.58E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:5.55|P-value:5.17E-8 ID:SGTC_2570|Compound:licareol|FD-Score:3.90|P-value:9.16E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.82|P-value:1.89E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.40|P-value:5.50E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.54|P-value:6.70E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.24|P-value:9.37E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.35|P-value:6.46E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.46|P-value:4.52E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:5.86|P-value:9.36E-9 ID:SGTC_2913|Compound:7966556|FD-Score:3.80|P-value:1.33E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.80|P-value:1.32E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.26|P-value:2.23E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.88|P-value:9.96E-5 ID:SGTC_3032|Compound:9089427|FD-Score:5.25|P-value:2.42E-7 ID:SGTC_3072|Compound:9116419|FD-Score:-3.96|P-value:7.28E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.46|P-value:9.48E-6 ID:SGTC_3170|Compound:9103054|FD-Score:4.07|P-value:4.69E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.09|P-value:4.31E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.45|P-value:4.74E-4

Top fitness defect scores for YOL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1886 st057356 7.96 49.9 µM 1.12E-14 60S ribosome export 2 8.72E-16
2 SGTC_2774 tamoxifen 5.86 10.9 µM 9.36E-9 2 2.30E-9
3 SGTC_2483 5729050 5.62 27.2 µM 3.43E-8 8 9.39E-9
4 SGTC_2518 prenyletin 5.55 46.3 µM 5.17E-8 1 1.46E-8
5 SGTC_2330 7979373 5.43 200.0 µM 9.38E-8 60S ribosome export 16 2.79E-8
6 SGTC_2937 9044753 5.26 11.3 µM 2.23E-7 60S ribosome export 13 7.12E-8
7 SGTC_3032 9089427 5.25 49.5 µM 2.42E-7 60S ribosome export 3 7.80E-8
8 SGTC_1676 st018489 5.21 23.4 µM 2.86E-7 60S ribosome export 11 9.33E-8
9 SGTC_2572 astragaloside iv 4.82 100.0 µM 1.89E-6 10 7.19E-7
10 SGTC_1744 st037937 4.73 38.9 µM 2.90E-6 9 1.15E-6
11 SGTC_1707 st032323 4.58 6.3 µM 5.53E-6 DNA damage response 43 2.30E-6
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.54 70.0 µM 6.70E-6 redox potentiating 57 2.84E-6
13 SGTC_3076 9116187 4.46 49.5 µM 9.48E-6 12 4.13E-6
14 SGTC_85 0868-0259 4.44 160.1 µM 1.01E-5 60S ribosome export 6 4.45E-6
15 SGTC_1664 st014217 4.13 9.0 µM 3.67E-5 60S ribosome export 8 1.79E-5
16 SGTC_3170 9103054 4.07 49.5 µM 4.69E-5 60S ribosome export 10 2.33E-5
17 SGTC_1748 st037455 4.06 53.6 µM 4.89E-5 29 2.44E-5
18 SGTC_55 0767-0285 4.05 6.6 µM 5.05E-5 40 2.53E-5
19 SGTC_2237 6667747 3.98 47.2 µM 6.75E-5 15 3.46E-5
20 SGTC_143 4032-1194 3.95 15.7 µM 7.43E-5 67 3.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.87E-28 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.172 1.01E-23 YOR072W_d YOR072W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
0.163 2.52E-21 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.111 1.26E-10 YBR054W YRO2 hom Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication
0.097 1.73E-8 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.085 7.91E-7 YIL096C_p YIL096C_p hom Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis
0.074 1.75E-5 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function
0.074 1.94E-5 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.073 2.61E-5 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.072 2.87E-5 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.071 3.71E-5 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.069 5.81E-5 YHR049C-A_d YHR049C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.48E-5 YHR077C NMD2 hom Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
0.069 7.22E-5 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.065 1.77E-4 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C