YOL072W / THP1

Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL072W / THP1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:4.69|P-value:5.88E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:4.33|P-value:1.91E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.90|P-value:6.99E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:9.31|P-value:7.05E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:4.70|P-value:5.70E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:5.49|P-value:3.10E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.91|P-value:2.77E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.12|P-value:3.62E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:8.69|P-value:3.52E-13 ID:SGTC_156|Compound:3474-0145|FD-Score:6.84|P-value:8.41E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.20|P-value:1.43E-14 ID:SGTC_264|Compound:promethazine|FD-Score:4.09|P-value:4.01E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.89|P-value:3.50E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.31|P-value:4.18E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:4.49|P-value:1.14E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.49|P-value:7.37E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.90|P-value:4.75E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.34|P-value:1.84E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.80|P-value:5.21E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:5.84|P-value:7.73E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.68|P-value:1.83E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.35|P-value:8.26E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.86|P-value:5.41E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.23|P-value:1.16E-14 ID:SGTC_543|Compound:3844-1095|FD-Score:6.45|P-value:5.25E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:5.46|P-value:3.53E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.06|P-value:4.42E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.73|P-value:7.93E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.83|P-value:8.70E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.22|P-value:2.69E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:5.01|P-value:1.90E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.07|P-value:4.33E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.36|P-value:1.75E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:5.60|P-value:2.00E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.68|P-value:3.55E-13 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.15|P-value:3.37E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.93|P-value:4.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-5.36|P-value:3.06E-6 ID:SGTC_1644|Compound:st010134|FD-Score:-3.89|P-value:4.95E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.56|P-value:5.83E-5 ID:SGTC_1671|Compound:st016596|FD-Score:4.27|P-value:2.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.59|P-value:8.30E-5 ID:SGTC_1687|Compound:st020778|FD-Score:8.50|P-value:1.07E-12 ID:SGTC_1694|Compound:st024011|FD-Score:5.28|P-value:7.02E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.18|P-value:3.07E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.62|P-value:7.36E-5 ID:SGTC_1738|Compound:st035555|FD-Score:5.34|P-value:5.69E-6 ID:SGTC_1750|Compound:st081859|FD-Score:10.50|P-value:1.90E-18 ID:SGTC_1754|Compound:st042065|FD-Score:6.34|P-value:8.63E-8 ID:SGTC_1760|Compound:st045453|FD-Score:4.90|P-value:2.84E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.62|P-value:7.35E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.91|P-value:6.88E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.01|P-value:3.49E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.40|P-value:1.55E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.01|P-value:3.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:4.41|P-value:1.48E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.86|P-value:7.97E-4 ID:SGTC_2036|Compound:5160441|FD-Score:8.70|P-value:3.32E-13 ID:SGTC_2108|Compound:5365811|FD-Score:4.81|P-value:3.91E-5 ID:SGTC_2136|Compound:5328288|FD-Score:5.22|P-value:8.69E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.17|P-value:3.20E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.00|P-value:5.26E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.25|P-value:2.43E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.47|P-value:3.54E-10 ID:SGTC_2363|Compound:9053361|FD-Score:4.60|P-value:7.87E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.02|P-value:3.56E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.77|P-value:2.87E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-4.16|P-value:2.15E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.65|P-value:9.76E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.24|P-value:2.57E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.34|P-value:1.20E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.27|P-value:2.31E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.11|P-value:3.74E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-8.21|P-value:2.72E-12 ID:SGTC_2810|Compound:7959871|FD-Score:-4.10|P-value:2.61E-4 ID:SGTC_2814|Compound:7977482|FD-Score:8.02|P-value:1.70E-11 ID:SGTC_2815|Compound:7968870|FD-Score:4.47|P-value:1.21E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.90|P-value:7.05E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.80|P-value:9.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.34|P-value:5.59E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.98|P-value:2.14E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.69|P-value:1.40E-6 ID:SGTC_2951|Compound:9072950|FD-Score:5.36|P-value:5.19E-6 ID:SGTC_2966|Compound:9084041|FD-Score:5.05|P-value:1.63E-5 ID:SGTC_2980|Compound:9014342|FD-Score:6.10|P-value:2.52E-7 ID:SGTC_3237|Compound:9133362|FD-Score:5.26|P-value:7.70E-6 ID:SGTC_5|Compound:0352-0601|FD-Score:4.69|P-value:5.88E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:4.33|P-value:1.91E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.90|P-value:6.99E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:9.31|P-value:7.05E-15 ID:SGTC_86|Compound:0417-1630|FD-Score:4.70|P-value:5.70E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:5.49|P-value:3.10E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.91|P-value:2.77E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.12|P-value:3.62E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:8.69|P-value:3.52E-13 ID:SGTC_156|Compound:3474-0145|FD-Score:6.84|P-value:8.41E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.20|P-value:1.43E-14 ID:SGTC_264|Compound:promethazine|FD-Score:4.09|P-value:4.01E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.89|P-value:3.50E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.31|P-value:4.18E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:4.49|P-value:1.14E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.49|P-value:7.37E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.90|P-value:4.75E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.34|P-value:1.84E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.80|P-value:5.21E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:5.84|P-value:7.73E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.68|P-value:1.83E-8 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.35|P-value:8.26E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.86|P-value:5.41E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.23|P-value:1.16E-14 ID:SGTC_543|Compound:3844-1095|FD-Score:6.45|P-value:5.25E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:5.46|P-value:3.53E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.06|P-value:4.42E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.73|P-value:7.93E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.83|P-value:8.70E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.22|P-value:2.69E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:5.01|P-value:1.90E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:4.07|P-value:4.33E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.36|P-value:1.75E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:5.60|P-value:2.00E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.68|P-value:3.55E-13 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.15|P-value:3.37E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.93|P-value:4.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-5.36|P-value:3.06E-6 ID:SGTC_1644|Compound:st010134|FD-Score:-3.89|P-value:4.95E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-4.56|P-value:5.83E-5 ID:SGTC_1671|Compound:st016596|FD-Score:4.27|P-value:2.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.59|P-value:8.30E-5 ID:SGTC_1687|Compound:st020778|FD-Score:8.50|P-value:1.07E-12 ID:SGTC_1694|Compound:st024011|FD-Score:5.28|P-value:7.02E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.18|P-value:3.07E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.62|P-value:7.36E-5 ID:SGTC_1738|Compound:st035555|FD-Score:5.34|P-value:5.69E-6 ID:SGTC_1750|Compound:st081859|FD-Score:10.50|P-value:1.90E-18 ID:SGTC_1754|Compound:st042065|FD-Score:6.34|P-value:8.63E-8 ID:SGTC_1760|Compound:st045453|FD-Score:4.90|P-value:2.84E-5 ID:SGTC_1801|Compound:st050089|FD-Score:4.62|P-value:7.35E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.91|P-value:6.88E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-4.01|P-value:3.49E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.40|P-value:1.55E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.01|P-value:3.40E-4 ID:SGTC_1974|Compound:st069448|FD-Score:4.41|P-value:1.48E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.86|P-value:7.97E-4 ID:SGTC_2036|Compound:5160441|FD-Score:8.70|P-value:3.32E-13 ID:SGTC_2108|Compound:5365811|FD-Score:4.81|P-value:3.91E-5 ID:SGTC_2136|Compound:5328288|FD-Score:5.22|P-value:8.69E-6 ID:SGTC_2183|Compound:6420625|FD-Score:4.17|P-value:3.20E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.00|P-value:5.26E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.25|P-value:2.43E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.47|P-value:3.54E-10 ID:SGTC_2363|Compound:9053361|FD-Score:4.60|P-value:7.87E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.02|P-value:3.56E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.77|P-value:2.87E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-4.16|P-value:2.15E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.65|P-value:9.76E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.24|P-value:2.57E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.34|P-value:1.20E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.27|P-value:2.31E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.11|P-value:3.74E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-8.21|P-value:2.72E-12 ID:SGTC_2810|Compound:7959871|FD-Score:-4.10|P-value:2.61E-4 ID:SGTC_2814|Compound:7977482|FD-Score:8.02|P-value:1.70E-11 ID:SGTC_2815|Compound:7968870|FD-Score:4.47|P-value:1.21E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.90|P-value:7.05E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.80|P-value:9.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.34|P-value:5.59E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.98|P-value:2.14E-5 ID:SGTC_2918|Compound:7977171|FD-Score:5.69|P-value:1.40E-6 ID:SGTC_2951|Compound:9072950|FD-Score:5.36|P-value:5.19E-6 ID:SGTC_2966|Compound:9084041|FD-Score:5.05|P-value:1.63E-5 ID:SGTC_2980|Compound:9014342|FD-Score:6.10|P-value:2.52E-7 ID:SGTC_3237|Compound:9133362|FD-Score:5.26|P-value:7.70E-6

Top fitness defect scores for YOL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 10.50 2.4 µM 1.90E-18 endomembrane recycling 40 4.57E-26
2 SGTC_43 0570-0105 9.31 72.5 µM 7.05E-15 ERG2 14 6.59E-21
3 SGTC_528 3492-0019 9.23 172.0 µM 1.16E-14 calcium & mitochondrial duress 49 1.36E-20
4 SGTC_221 trifluoperazine 9.20 10.3 µM 1.43E-14 NEO1-PIK1 70 1.83E-20
5 SGTC_2036 5160441 8.70 105.0 µM 3.32E-13 NEO1 22 1.72E-18
6 SGTC_146 3448-8650 8.69 53.1 µM 3.52E-13 NEO1-PIK1 22 1.88E-18
7 SGTC_1304 1165-0502 8.68 251.0 µM 3.55E-13 15 1.90E-18
8 SGTC_1687 st020778 8.50 55.4 µM 1.07E-12 60 9.36E-18
9 SGTC_2814 7977482 8.02 43.0 µM 1.70E-11 3 5.10E-16
10 SGTC_2322 7413319 7.47 38.2 µM 3.54E-10 ERAD & cell cycle 40 4.07E-14
11 SGTC_156 3474-0145 6.84 5.6 µM 8.41E-9 endomembrane recycling 13 3.94E-12
12 SGTC_445 e6 berbamine 6.68 66.0 µM 1.83E-8 NEO1-PIK1 21 1.21E-11
13 SGTC_543 3844-1095 6.45 191.0 µM 5.25E-8 ERG2 13 5.53E-11
14 SGTC_449 xestospongin c 6.35 11.2 µM 8.26E-8 NEO1-PIK1 18 1.06E-10
15 SGTC_1754 st042065 6.34 16.1 µM 8.63E-8 NEO1-PIK1 88 1.13E-10
16 SGTC_2980 9014342 6.10 25.3 µM 2.52E-7 11 5.32E-10
17 SGTC_2489 cantharidin 6.02 73.4 µM 3.56E-7 cell wall signaling 11 8.73E-10
18 SGTC_439 amiodarone 5.84 34.4 µM 7.73E-7 NEO1-PIK1 47 2.67E-9
19 SGTC_2918 7977171 5.69 22.1 µM 1.40E-6 6 6.26E-9
20 SGTC_975 1335-0046 5.60 28.5 µM 2.00E-6 RPP1 & pyrimidine depletion 11 1.05E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 9.58E-176 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.316 1.26E-78 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.302 1.14E-71 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.296 1.14E-68 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.275 2.83E-59 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.266 2.43E-55 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.263 2.59E-54 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.262 2.03E-53 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.252 8.11E-50 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.251 1.60E-49 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.244 1.31E-46 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.242 6.97E-46 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.241 1.18E-45 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.234 4.21E-43 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.228 8.16E-41 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin