YOL078W / AVO1

Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL078W / AVO1

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:-2.80|P-value:4.85E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:4.75|P-value:6.58E-9 ID:SGTC_189|Compound:3970-0742|FD-Score:3.19|P-value:6.51E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.54|P-value:1.09E-5 ID:SGTC_205|Compound:1486-1330|FD-Score:-2.70|P-value:7.18E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.62|P-value:8.17E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.79|P-value:3.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.66|P-value:8.51E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.99|P-value:2.09E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.75|P-value:5.83E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.84|P-value:4.06E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.46|P-value:1.66E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.75|P-value:3.55E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.49|P-value:5.59E-8 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.82|P-value:4.44E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.76|P-value:4.60E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-2.74|P-value:6.21E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.66|P-value:7.05E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-2.64|P-value:9.50E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.61|P-value:8.40E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.93|P-value:2.15E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.21|P-value:5.96E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.15|P-value:8.03E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.14|P-value:8.30E-5 ID:SGTC_2125|Compound:5246583|FD-Score:5.74|P-value:3.50E-12 ID:SGTC_2196|Compound:6573537|FD-Score:2.79|P-value:4.01E-4 ID:SGTC_2200|Compound:6600604|FD-Score:2.98|P-value:1.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.00|P-value:8.40E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-2.97|P-value:2.33E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.26|P-value:4.73E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.77|P-value:3.11E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.70|P-value:5.90E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-2.66|P-value:8.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-2.91|P-value:3.04E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.36|P-value:2.83E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.46|P-value:1.69E-5 ID:SGTC_3215|Compound:9129942|FD-Score:2.96|P-value:1.89E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.12|P-value:9.07E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.64|P-value:7.61E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.80|P-value:4.85E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:4.75|P-value:6.58E-9 ID:SGTC_189|Compound:3970-0742|FD-Score:3.19|P-value:6.51E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.54|P-value:1.09E-5 ID:SGTC_205|Compound:1486-1330|FD-Score:-2.70|P-value:7.18E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.62|P-value:8.17E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.79|P-value:3.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.66|P-value:8.51E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.99|P-value:2.09E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.75|P-value:5.83E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.84|P-value:4.06E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.46|P-value:1.66E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.75|P-value:3.55E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.49|P-value:5.59E-8 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.82|P-value:4.44E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.76|P-value:4.60E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-2.74|P-value:6.21E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.66|P-value:7.05E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-2.64|P-value:9.50E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.61|P-value:8.40E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.93|P-value:2.15E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.21|P-value:5.96E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.15|P-value:8.03E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.14|P-value:8.30E-5 ID:SGTC_2125|Compound:5246583|FD-Score:5.74|P-value:3.50E-12 ID:SGTC_2196|Compound:6573537|FD-Score:2.79|P-value:4.01E-4 ID:SGTC_2200|Compound:6600604|FD-Score:2.98|P-value:1.71E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.00|P-value:8.40E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-2.97|P-value:2.33E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.26|P-value:4.73E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.77|P-value:3.11E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.70|P-value:5.90E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-2.66|P-value:8.46E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-2.91|P-value:3.04E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.36|P-value:2.83E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.46|P-value:1.69E-5 ID:SGTC_3215|Compound:9129942|FD-Score:2.96|P-value:1.89E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.12|P-value:9.07E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.64|P-value:7.61E-4

Top fitness defect scores for YOL078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2125 5246583 5.74 200.0 µM 3.50E-12 tubulin folding & SWR complex 1 4.82E-9 0.84
2 SGTC_186 3455-3465 4.75 67.3 µM 6.58E-9 2 1.01E-6 0.61
3 SGTC_2248 tofa 4.00 1.1 µM 8.40E-7 sphingolipid biosynthesis & PDR1 26 3.19E-5 0.01
4 SGTC_2605 digitonin 3.77 300.0 nM 3.11E-6 4 8.11E-5 0.05
5 SGTC_1013 4112-3890 3.75 241.0 µM 3.55E-6 TSC3-RPN4 8 8.91E-5 0.11
6 SGTC_201 4262-0159 3.54 12.8 µM 1.09E-5 ergosterol depletion effects on membrane 14 1.99E-4 0.21
7 SGTC_1010 4112-3296 3.46 15.2 µM 1.66E-5 9 2.68E-4 0.11
8 SGTC_3202 9113761 3.46 49.5 µM 1.69E-5 15 2.72E-4 0.01
9 SGTC_3014 9081533 3.36 49.5 µM 2.83E-5 9 3.93E-4 0.08
10 SGTC_2257 7960413 3.26 200.0 µM 4.73E-5 NEO1-PIK1 26 5.67E-4 0.02
11 SGTC_1716 st033144 3.21 30.6 µM 5.96E-5 13 6.69E-4 0.24
12 SGTC_189 3970-0742 3.19 2.1 µM 6.51E-5 5 7.12E-4 0.04
13 SGTC_2012 4023501 3.15 200.0 µM 8.03E-5 22 8.28E-4 0.16
14 SGTC_2021 4019055 3.14 173.0 µM 8.30E-5 endomembrane recycling 50 8.48E-4 0.09
15 SGTC_3222 9128301 3.12 49.5 µM 9.07E-5 60S ribosome export 16 9.04E-4 0.03
16 SGTC_2200 6600604 2.98 21.9 µM 1.71E-4 tubulin folding & SWR complex 14 0.00143 0.04
17 SGTC_3215 9129942 2.96 49.5 µM 1.89E-4 18 0.00153 0.14
18 SGTC_1715 st032160 2.93 10.2 µM 2.15E-4 20 0.00168 0.03
19 SGTC_743 1275-0778 2.79 158.0 µM 3.99E-4 excess fatty acid 31 0.00262 0.00
20 SGTC_2196 6573537 2.79 42.7 µM 4.01E-4 copper-dependent oxidative stress 15 0.00263 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 5.59E-22 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.158 4.65E-20 YNL162W-A_p YNL162W-A_p hom Putative protein of unknown function; identified by homology
0.145 3.27E-17 YNL203C_d YNL203C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 9.10E-16 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.136 2.14E-15 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.132 1.47E-14 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.131 2.36E-14 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.127 1.94E-13 YHR121W LSM12 hom Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
0.125 3.63E-13 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.125 4.12E-13 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.124 7.06E-13 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.121 1.67E-12 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.120 2.46E-12 YPL119C-A_p YPL119C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.118 6.19E-12 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.118 7.79E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm