YOL080C / REX4

Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL080C / REX4

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.07|P-value:7.01E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.59|P-value:6.38E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.02|P-value:7.30E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.83|P-value:1.68E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.30|P-value:2.48E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.68|P-value:3.80E-7 ID:SGTC_645|Compound:0845-0943|FD-Score:3.18|P-value:3.36E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:2.98|P-value:7.22E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.62|P-value:5.57E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.37|P-value:1.91E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.33|P-value:1.83E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.12|P-value:5.05E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.92|P-value:8.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.33|P-value:1.88E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.10|P-value:5.35E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.71|P-value:3.65E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:8.29E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.00|P-value:7.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.09|P-value:5.69E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.37|P-value:1.88E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-2.99|P-value:8.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.99|P-value:8.01E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.07|P-value:7.01E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.59|P-value:6.38E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.02|P-value:7.30E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.83|P-value:1.68E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.30|P-value:2.48E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.68|P-value:3.80E-7 ID:SGTC_645|Compound:0845-0943|FD-Score:3.18|P-value:3.36E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:2.98|P-value:7.22E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.62|P-value:5.57E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.37|P-value:1.91E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.33|P-value:1.83E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.12|P-value:5.05E-4 ID:SGTC_2076|Compound:5212012|FD-Score:2.92|P-value:8.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.33|P-value:1.88E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.10|P-value:5.35E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.71|P-value:3.65E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:8.29E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.00|P-value:7.89E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.09|P-value:5.69E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.37|P-value:1.88E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-2.99|P-value:8.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.99|P-value:8.01E-4

Top fitness defect scores for YOL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 4.07 266.0 µM 7.01E-6 ubiquinone biosynthesis & proteasome 115 2.37E-5
2 SGTC_2493 resveratrol 3.71 26.1 µM 3.65E-5 12 1.02E-4
3 SGTC_822 1487-0950 3.62 154.0 µM 5.57E-5 22 1.49E-4
4 SGTC_127 0180-0333 3.59 59.1 µM 6.38E-5 mitochondrial response to ROS 59 1.68E-4
5 SGTC_288 1315-0019 3.47 35.1 µM 1.03E-4 RSC & ERG11 34 2.56E-4
6 SGTC_1938 st074717 3.33 56.4 µM 1.83E-4 24 4.27E-4
7 SGTC_2329 6138490 3.33 200.0 µM 1.88E-4 61 4.40E-4
8 SGTC_645 0845-0943 3.18 5.4 µM 3.36E-4 60S ribosome export 32 7.35E-4
9 SGTC_1043 0916-0009 3.09 19.3 µM 4.69E-4 61 9.89E-4
10 SGTC_865 0488-0499 3.04 301.0 µM 5.84E-4 48 0.00120
11 SGTC_717 1532-0246 2.98 73.2 µM 7.22E-4 Golgi 83 0.00145
12 SGTC_2076 5212012 2.92 200.0 µM 8.87E-4 25 0.00174
13 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 2.82 4.6 µM 0.00129 heat shock/prefoldin 96 0.00244
14 SGTC_659 k018-0002 2.81 107.0 µM 0.00131 64 0.00247
15 SGTC_817 1391-0715 2.77 46.0 µM 0.00150 66 0.00277
16 SGTC_1219 1469-0211 2.74 33.1 µM 0.00170 62 0.00310
17 SGTC_1793 st048256 2.73 72.2 µM 0.00174 32 0.00317
18 SGTC_2693 st077581 2.68 40.7 µM 0.00207 128 0.00370
19 SGTC_2691 st077356 2.66 60.2 µM 0.00217 106 0.00386
20 SGTC_1799 st045822 2.65 46.1 µM 0.00231 79 0.00408

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 1.93E-18 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.150 2.39E-18 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.147 1.12E-17 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.140 4.24E-16 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.134 5.77E-15 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.132 1.33E-14 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.130 4.69E-14 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.125 4.29E-13 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.123 8.58E-13 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.115 2.35E-11 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.112 6.47E-11 YEL012W UBC8 hom Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
0.110 1.59E-10 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.109 2.29E-10 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.107 5.18E-10 YML090W_d YML090W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
0.106 7.52E-10 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction