YOL085C_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL085C / YOL085C

Click on Significant Values for Screen Details ID:SGTC_180|Compound:1486-1293|FD-Score:4.44|P-value:3.46E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.36|P-value:3.37E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.80|P-value:6.07E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.27|P-value:4.75E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.09|P-value:8.36E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.44|P-value:2.53E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.12|P-value:7.59E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.85|P-value:4.94E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:4.45|P-value:3.31E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:3.18|P-value:6.58E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.42|P-value:2.75E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.26|P-value:4.93E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.72|P-value:7.90E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.85|P-value:4.47E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.43|P-value:3.59E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.12|P-value:1.52E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:2.57E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.08|P-value:9.23E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.16|P-value:7.06E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.18|P-value:6.54E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.20|P-value:5.71E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.24|P-value:8.85E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.60|P-value:1.35E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.37|P-value:3.09E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.11|P-value:7.95E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.14|P-value:7.35E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.79|P-value:2.24E-9 ID:SGTC_2799|Compound:7812892|FD-Score:4.34|P-value:5.52E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.70|P-value:9.12E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.20|P-value:1.07E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.46|P-value:2.13E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.44|P-value:3.46E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.36|P-value:3.37E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.80|P-value:6.07E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.27|P-value:4.75E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.09|P-value:8.36E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.44|P-value:2.53E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.12|P-value:7.59E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.85|P-value:4.94E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:4.45|P-value:3.31E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:3.18|P-value:6.58E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.42|P-value:2.53E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.42|P-value:2.75E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.26|P-value:4.93E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.72|P-value:7.90E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.85|P-value:4.47E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.43|P-value:3.59E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.12|P-value:1.52E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:2.57E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.08|P-value:9.23E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.16|P-value:7.06E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.28|P-value:4.46E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.18|P-value:6.54E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.20|P-value:5.71E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.24|P-value:8.85E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.60|P-value:1.35E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.37|P-value:3.09E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.11|P-value:7.95E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.14|P-value:7.35E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.79|P-value:2.24E-9 ID:SGTC_2799|Compound:7812892|FD-Score:4.34|P-value:5.52E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.70|P-value:9.12E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.20|P-value:1.07E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-3.46|P-value:2.13E-4

Top fitness defect scores for YOL085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2769 toremifene 5.79 3.7 µM 2.24E-9 4 3.49E-9
2 SGTC_728 3030-5151 4.45 22.5 µM 3.31E-6 9 4.28E-6
3 SGTC_180 1486-1293 4.44 102.8 µM 3.46E-6 30 4.47E-6
4 SGTC_1204 4049-0315 4.43 18.3 µM 3.59E-6 16 4.62E-6
5 SGTC_2799 7812892 4.34 81.8 µM 5.52E-6 superoxide 22 7.03E-6
6 SGTC_2334 9017922 4.24 200.0 µM 8.85E-6 18 1.12E-5
7 SGTC_2969 9091408 4.20 28.7 µM 1.07E-5 21 1.34E-5
8 SGTC_693 4161-2696 4.17 114.0 µM 1.20E-5 6 1.50E-5
9 SGTC_1213 1315-0166 4.12 115.0 µM 1.52E-5 24 1.89E-5
10 SGTC_725 1497-0963 3.85 19.0 µM 4.94E-5 copper-dependent oxidative stress 20 5.97E-5
11 SGTC_355 1311-2252 3.80 105.0 µM 6.07E-5 26 7.29E-5
12 SGTC_2924 9010168 3.70 62.8 µM 9.12E-5 cell wall signaling 48 1.08E-4
13 SGTC_2681 menadione 3.60 3.2 µM 1.35E-4 superoxide 34 1.59E-4
14 SGTC_692 k241-0027 3.44 77.8 µM 2.53E-4 20 2.93E-4
15 SGTC_722 3534-0461 3.42 190.0 µM 2.72E-4 PDR1 56 3.16E-4
16 SGTC_909 3448-9333 3.42 149.0 µM 2.75E-4 30 3.18E-4
17 SGTC_2752 diclazuril 3.37 33.1 µM 3.25E-4 164 3.74E-4
18 SGTC_315 k915-0449 3.36 187.0 µM 3.37E-4 79 3.89E-4
19 SGTC_2112 5488546 3.28 200.0 µM 4.46E-4 TSC3-RPN4 40 5.11E-4
20 SGTC_375 3970-0961 3.27 9.3 µM 4.75E-4 tubulin folding & SWR complex 46 5.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.69E-15 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.115 2.40E-11 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.110 2.02E-10 YHR049C-A_d YHR049C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.55E-9 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.102 2.80E-9 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.101 4.16E-9 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.098 1.26E-8 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.098 1.42E-8 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.095 3.53E-8 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.094 5.34E-8 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.093 7.43E-8 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.088 3.35E-7 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.087 4.80E-7 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.083 1.51E-6 YGR080W TWF1 hom Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
0.082 2.09E-6 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation