YOL089C / HAL9

Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL089C / HAL9

Click on Significant Values for Screen Details ID:SGTC_121|Compound:0557-0495|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.66|P-value:3.20E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.12|P-value:6.98E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.26|P-value:2.04E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:6.86|P-value:3.91E-12 ID:SGTC_361|Compound:000s-0510|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.56|P-value:2.16E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.94|P-value:3.24E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:6.36|P-value:1.06E-10 ID:SGTC_637|Compound:1181-0519|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.25|P-value:3.28E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.60|P-value:1.78E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.33|P-value:6.11E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.25|P-value:6.83E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:3.83|P-value:5.04E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.91|P-value:3.64E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.95|P-value:3.06E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.21|P-value:5.21E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.29|P-value:3.95E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.47|P-value:2.11E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.56|P-value:4.59E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.06|P-value:8.65E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.10|P-value:1.47E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.84|P-value:4.93E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:6.23|P-value:2.38E-10 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.09|P-value:1.72E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.01|P-value:2.44E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.01|P-value:9.97E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.59|P-value:4.10E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.78|P-value:6.19E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.34|P-value:3.24E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-4.28|P-value:2.95E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.70|P-value:8.51E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.94|P-value:3.32E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.12|P-value:7.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:1.46E-7 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:5.32E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.25|P-value:4.53E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.03|P-value:9.43E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.90|P-value:3.82E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.37|P-value:3.53E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-3.36|P-value:8.97E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.29|P-value:5.51E-8 ID:SGTC_2576|Compound:guaiol|FD-Score:3.07|P-value:8.16E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.94|P-value:3.44E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.21|P-value:5.16E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.02|P-value:9.70E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.83|P-value:2.69E-9 ID:SGTC_2905|Compound:7799065|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.39|P-value:8.11E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.36|P-value:3.08E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.08|P-value:8.80E-13 ID:SGTC_3321|Compound:9137793|FD-Score:3.32|P-value:3.54E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.46|P-value:2.15E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.66|P-value:3.20E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.12|P-value:6.98E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.26|P-value:2.04E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:6.86|P-value:3.91E-12 ID:SGTC_361|Compound:000s-0510|FD-Score:3.57|P-value:1.41E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.56|P-value:2.16E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.94|P-value:3.24E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:6.36|P-value:1.06E-10 ID:SGTC_637|Compound:1181-0519|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.15|P-value:1.36E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.25|P-value:3.28E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.60|P-value:1.78E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.33|P-value:6.11E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.25|P-value:6.83E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:3.83|P-value:5.04E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.91|P-value:3.64E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.95|P-value:3.06E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.21|P-value:5.21E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.29|P-value:3.95E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.47|P-value:2.11E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.56|P-value:4.59E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.06|P-value:8.65E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.10|P-value:1.47E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.84|P-value:4.93E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:6.23|P-value:2.38E-10 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.09|P-value:1.72E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.01|P-value:2.44E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.01|P-value:9.97E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.59|P-value:4.10E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.78|P-value:6.19E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.37|P-value:2.92E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.34|P-value:3.24E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-4.28|P-value:2.95E-5 ID:SGTC_1848|Compound:st056003|FD-Score:3.70|P-value:8.51E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.94|P-value:3.32E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.12|P-value:7.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:1.46E-7 ID:SGTC_1981|Compound:st071826|FD-Score:3.20|P-value:5.32E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.25|P-value:4.53E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.03|P-value:9.43E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.90|P-value:3.82E-5 ID:SGTC_2296|Compound:7971656|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.37|P-value:3.53E-8 ID:SGTC_2307|Compound:7538926|FD-Score:-3.36|P-value:8.97E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.29|P-value:5.51E-8 ID:SGTC_2576|Compound:guaiol|FD-Score:3.07|P-value:8.16E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.94|P-value:3.44E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.21|P-value:5.16E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.02|P-value:9.70E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.83|P-value:2.69E-9 ID:SGTC_2905|Compound:7799065|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.39|P-value:8.11E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.36|P-value:3.08E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.08|P-value:8.80E-13 ID:SGTC_3321|Compound:9137793|FD-Score:3.32|P-value:3.54E-4

Top fitness defect scores for YOL089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3311 9131146 7.08 2.9 µM 8.80E-13 cell wall 45 7.25E-13
2 SGTC_341 1486-1430 6.86 230.0 µM 3.91E-12 3 3.37E-12
3 SGTC_542 3381-0244 6.36 89.3 µM 1.06E-10 14 1.00E-10
4 SGTC_221 trifluoperazine 6.26 10.3 µM 2.04E-10 NEO1-PIK1 115 1.97E-10
5 SGTC_1535 tetrahydropapaveroline hydrobromide 6.23 54.3 µM 2.38E-10 RPP1 & pyrimidine depletion 1 2.30E-10
6 SGTC_2756 carbadox 5.83 75.1 µM 2.69E-9 18 2.77E-9
7 SGTC_1054 3429-0080 5.47 167.0 µM 2.11E-8 9 2.29E-8
8 SGTC_2302 7771753 5.37 200.0 µM 3.53E-8 17 3.87E-8
9 SGTC_2466 5983409 5.29 37.1 µM 5.51E-8 6 6.11E-8
10 SGTC_863 0466-0191 5.25 129.0 µM 6.83E-8 cell wall 39 7.61E-8
11 SGTC_1959 st077091 5.11 55.8 µM 1.46E-7 RPP1 & pyrimidine depletion 23 1.65E-7
12 SGTC_1346 1488-2224 5.10 62.4 µM 1.47E-7 12 1.67E-7
13 SGTC_2582 agaric acid 4.94 100.0 µM 3.44E-7 redox potentiating 227 3.97E-7
14 SGTC_649 1123-0311 4.60 367.0 µM 1.78E-6 endomembrane recycling 46 2.12E-6
15 SGTC_524 r073-0010 4.56 27.8 µM 2.16E-6 38 2.59E-6
16 SGTC_768 0384-0033 4.33 77.3 µM 6.11E-6 fatty acid desaturase (OLE1) 72 7.45E-6
17 SGTC_2454 5-benzylidenerhodanine 4.21 10.4 µM 1.05E-5 TRP & mitochondrial translation 29 1.29E-5
18 SGTC_641 4092-0595 4.15 30.0 µM 1.36E-5 11 1.68E-5
19 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.09 61.9 µM 1.72E-5 14 2.13E-5
20 SGTC_1623 st003709 4.01 20.3 µM 2.44E-5 calcium & mitochondrial duress 68 3.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.70E-40 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.201 8.88E-32 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.191 5.80E-29 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.190 1.01E-28 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.186 1.42E-27 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.181 4.23E-26 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.178 2.00E-25 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.176 1.14E-24 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.175 1.86E-24 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.171 2.54E-23 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.168 9.63E-23 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.165 6.15E-22 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.160 1.15E-20 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.153 4.94E-19 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.152 8.79E-19 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies