YOL091W / SPO21

Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL091W / SPO21

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.23|P-value:3.94E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.14|P-value:5.46E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.85E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.73|P-value:6.77E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.53|P-value:1.56E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.07|P-value:1.18E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.04|P-value:7.69E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.77|P-value:4.45E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-5.41|P-value:1.48E-8 ID:SGTC_780|Compound:0109-0199|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.40|P-value:3.44E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.34|P-value:4.45E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.65|P-value:7.42E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.82|P-value:3.57E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.69|P-value:6.34E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:5.60|P-value:3.35E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.79|P-value:4.12E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.64|P-value:9.95E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.35|P-value:3.13E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.74|P-value:6.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-3.37|P-value:2.95E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.28|P-value:4.06E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.29|P-value:3.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.18|P-value:4.76E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.60|P-value:1.18E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.98|P-value:1.77E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.58|P-value:5.45E-9 ID:SGTC_1958|Compound:st076513|FD-Score:3.22|P-value:4.05E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.07|P-value:6.89E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.21|P-value:4.17E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.63|P-value:7.67E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.45|P-value:2.59E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.39|P-value:2.70E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.50|P-value:1.37E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.24|P-value:3.82E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:7.07|P-value:1.28E-13 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.14|P-value:4.94E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.10|P-value:6.24E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.76|P-value:3.93E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.07|P-value:6.93E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_3131|Compound:9127911|FD-Score:6.92|P-value:4.05E-13 ID:SGTC_3201|Compound:9113999|FD-Score:2.99|P-value:9.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:2.98|P-value:9.63E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.23|P-value:3.94E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.14|P-value:5.46E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.85E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.73|P-value:6.77E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.53|P-value:1.56E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.07|P-value:1.18E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.04|P-value:7.69E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.77|P-value:4.45E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-5.41|P-value:1.48E-8 ID:SGTC_780|Compound:0109-0199|FD-Score:3.03|P-value:7.91E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.42|P-value:1.89E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-4.40|P-value:3.44E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.34|P-value:4.45E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.65|P-value:7.42E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.82|P-value:3.57E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.69|P-value:6.34E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:5.60|P-value:3.35E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.79|P-value:4.12E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.64|P-value:9.95E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.35|P-value:3.13E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.74|P-value:6.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-3.37|P-value:2.95E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.28|P-value:4.06E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.29|P-value:3.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.18|P-value:4.76E-4 ID:SGTC_1897|Compound:st060201|FD-Score:-3.60|P-value:1.18E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.98|P-value:1.77E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-5.58|P-value:5.45E-9 ID:SGTC_1958|Compound:st076513|FD-Score:3.22|P-value:4.05E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.07|P-value:6.89E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.21|P-value:4.17E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.63|P-value:7.67E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.45|P-value:2.59E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.39|P-value:2.70E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.50|P-value:1.37E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.24|P-value:3.82E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:7.07|P-value:1.28E-13 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.14|P-value:4.94E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.10|P-value:6.24E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.76|P-value:3.93E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_2819|Compound:7996655|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.12|P-value:7.17E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.07|P-value:6.93E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_3131|Compound:9127911|FD-Score:6.92|P-value:4.05E-13 ID:SGTC_3201|Compound:9113999|FD-Score:2.99|P-value:9.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:2.98|P-value:9.63E-4

Top fitness defect scores for YOL091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 7.07 54.6 µM 1.28E-13 RPP1 & pyrimidine depletion 2 7.84E-13
2 SGTC_3131 9127911 6.92 49.5 µM 4.05E-13 1 2.31E-12
3 SGTC_1214 0358-0031 5.60 63.7 µM 3.35E-9 3 1.10E-8
4 SGTC_2593 nobiletin 5.14 86.2 µM 4.94E-8 10 1.37E-7
5 SGTC_2639 lactacystin 5.10 53.0 µM 6.24E-8 11 1.71E-7
6 SGTC_2640 pentamidine 4.76 10.4 µM 3.93E-7 mitochondrial processes 13 9.59E-7
7 SGTC_2240 6690706 4.63 185.9 µM 7.67E-7 8 1.79E-6
8 SGTC_406 estrone 4.07 100.0 µM 1.18E-5 8 2.32E-5
9 SGTC_2598 perillyl alcohol 4.02 100.0 µM 1.52E-5 29 2.95E-5
10 SGTC_2810 7959871 4.01 45.5 µM 1.59E-5 copper-dependent oxidative stress 37 3.09E-5
11 SGTC_1950 st077106 3.98 7.2 µM 1.77E-5 RNA processing & uracil transport 28 3.41E-5
12 SGTC_1136 pergolide 3.82 1.1 µM 3.57E-5 42 6.59E-5
13 SGTC_1264 0783-0040 3.79 158.0 µM 4.12E-5 32 7.53E-5
14 SGTC_514 4466-0038 3.77 2.6 nM 4.45E-5 cell wall 165 8.10E-5
15 SGTC_1160 4092-0570 3.69 10.5 µM 6.34E-5 plasma membrane duress 46 1.13E-4
16 SGTC_1105 epirubicin 3.65 18.1 µM 7.42E-5 anthracycline transcription coupled DNA repair 27 1.31E-4
17 SGTC_991 3996-0057 3.55 64.7 µM 1.10E-4 32 1.90E-4
18 SGTC_1995 st072814 3.55 61.1 µM 1.14E-4 21 1.96E-4
19 SGTC_2402 5553605 3.50 200.0 µM 1.37E-4 52 2.33E-4
20 SGTC_2433 5607874 3.44 27.8 µM 1.74E-4 35 2.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.67E-9 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.096 2.71E-8 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.094 4.37E-8 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.092 1.06E-7 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.087 4.13E-7 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.087 4.74E-7 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.085 7.43E-7 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.082 1.84E-6 YNL194C YNL194C hom Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate
0.081 2.88E-6 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.080 3.92E-6 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.076 1.14E-5 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.074 1.66E-5 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.074 1.78E-5 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.073 2.18E-5 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.073 2.27E-5 YMR205C PFK2 hom Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes