YOL092W / YPQ1

Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL092W / YPQ1

Click on Significant Values for Screen Details

Top fitness defect scores for YOL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1399 3562-5772 5.75 25.0 µM 5.71E-10 RPP1 & pyrimidine depletion 3 4.58E-9
2 SGTC_762 1165-0429 5.20 115.0 µM 1.74E-8 TSC3-RPN4 5 9.71E-8
3 SGTC_2054 5233173 5.09 129.0 µM 3.51E-8 mitochondrial response to ROS 23 1.81E-7
4 SGTC_1987 st072290 4.89 61.9 µM 1.08E-7 3 4.96E-7
5 SGTC_2646 retinol 4.46 96.8 µM 1.16E-6 3 4.12E-6
6 SGTC_2052 5265182 4.43 7.1 µM 1.36E-6 17 4.78E-6
7 SGTC_849 0386-0493 4.32 241.0 µM 2.31E-6 10 7.66E-6
8 SGTC_1131 3454-3128 4.31 32.3 µM 2.52E-6 29 8.28E-6
9 SGTC_180 1486-1293 4.21 102.8 µM 4.05E-6 37 1.27E-5
10 SGTC_594 1487-1584 3.94 10.8 µM 1.51E-5 26 4.12E-5
11 SGTC_2343 7990716 3.86 14.8 µM 2.13E-5 20 5.58E-5
12 SGTC_2422 chlorphenesin carbamate 3.81 384.2 µM 2.76E-5 30 7.04E-5
13 SGTC_2419 paclitaxel 3.80 166.5 µM 2.85E-5 47 7.26E-5
14 SGTC_790 1575-0012 3.73 79.1 µM 3.82E-5 TSC3-RPN4 34 9.43E-5
15 SGTC_2571 chrysanthemic acid 3.72 100.0 µM 4.08E-5 29 9.99E-5
16 SGTC_1323 1348-1351 3.66 11.2 µM 5.26E-5 15 1.26E-4
17 SGTC_2786 7743617 3.62 45.5 µM 6.25E-5 38 1.46E-4
18 SGTC_2105 5350118 3.58 200.0 µM 7.54E-5 36 1.73E-4
19 SGTC_1767 st044992 3.57 70.3 µM 7.73E-5 31 1.77E-4
20 SGTC_1673 st016611 3.48 27.3 µM 1.15E-4 65 2.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.70E-9 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.103 2.56E-9 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.079 4.57E-6 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.079 5.15E-6 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.078 5.80E-6 YLR448W RPL6B hom Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
0.078 7.04E-6 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.077 1.05E-5 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.076 1.06E-5 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.074 1.78E-5 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.070 5.33E-5 YJL060W BNA3 hom Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
0.067 9.43E-5 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.067 1.05E-4 YFR056C_d YFR056C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.065 1.73E-4 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.065 1.78E-4 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.064 1.99E-4 YMR244W_p YMR244W_p hom Putative protein of unknown function