YOL095C / HMI1

Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL095C / HMI1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:7.28|P-value:3.20E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:4.19|P-value:8.18E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.69|P-value:1.25E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:6.20|P-value:1.28E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:4.68|P-value:1.31E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:1.21E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.76|P-value:3.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:4.36|P-value:4.34E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.35|P-value:2.87E-11 ID:SGTC_161|Compound:4065-0411|FD-Score:6.37|P-value:5.37E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:11.20|P-value:4.01E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:7.10E-42 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.09|P-value:2.01E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:8.14|P-value:1.43E-13 ID:SGTC_609|Compound:0986-0026|FD-Score:3.54|P-value:7.16E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:9.84E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.32|P-value:1.12E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.08|P-value:1.21E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.74|P-value:3.82E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.65|P-value:5.96E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.66|P-value:1.39E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.62|P-value:1.62E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.63|P-value:5.46E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.46|P-value:4.76E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.86|P-value:2.52E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.12|P-value:2.11E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:6.29|P-value:8.19E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:6.85|P-value:3.84E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:3.45|P-value:9.33E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.18|P-value:1.03E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:5.48|P-value:4.17E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:-5.31|P-value:1.15E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.55|P-value:8.01E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.95|P-value:5.34E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.78|P-value:1.07E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:3.62E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.93|P-value:2.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:2.34E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.02|P-value:3.17E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.46|P-value:4.74E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.82|P-value:7.36E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.63|P-value:5.42E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.68|P-value:5.33E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.57|P-value:7.59E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.70|P-value:1.20E-5 ID:SGTC_1615|Compound:st002656|FD-Score:4.10|P-value:1.14E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.49|P-value:8.35E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.48|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.46|P-value:9.11E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.19|P-value:1.56E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-4.67|P-value:1.67E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.98|P-value:3.88E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.59|P-value:7.08E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:2.25E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.67|P-value:4.69E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.48|P-value:8.66E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.80|P-value:3.14E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.91|P-value:2.14E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.54|P-value:2.25E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.76|P-value:4.22E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.53|P-value:8.60E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-6.05|P-value:3.60E-8 ID:SGTC_2379|Compound:9035213|FD-Score:-4.73|P-value:1.30E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-4.12|P-value:1.27E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.58|P-value:2.33E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.71|P-value:1.44E-7 ID:SGTC_2472|Compound:5377652|FD-Score:3.68|P-value:4.62E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.92|P-value:2.48E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.02|P-value:1.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.82|P-value:6.31E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:-6.23|P-value:1.43E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.87|P-value:2.96E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.87|P-value:7.41E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.84|P-value:1.42E-12 ID:SGTC_3018|Compound:9082602|FD-Score:4.53|P-value:2.31E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-3.68|P-value:5.48E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.78|P-value:3.35E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.69|P-value:4.50E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.75|P-value:4.37E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:7.28|P-value:3.20E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:4.19|P-value:8.18E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.69|P-value:1.25E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:6.20|P-value:1.28E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:4.68|P-value:1.31E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:1.21E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.76|P-value:3.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:4.36|P-value:4.34E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.35|P-value:2.87E-11 ID:SGTC_161|Compound:4065-0411|FD-Score:6.37|P-value:5.37E-9 ID:SGTC_173|Compound:1273-0061|FD-Score:11.20|P-value:4.01E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:7.10E-42 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.09|P-value:2.01E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:8.14|P-value:1.43E-13 ID:SGTC_609|Compound:0986-0026|FD-Score:3.54|P-value:7.16E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:9.84E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.32|P-value:1.12E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.08|P-value:1.21E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.74|P-value:3.82E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.65|P-value:5.96E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.66|P-value:1.39E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.62|P-value:1.62E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.63|P-value:5.46E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.46|P-value:4.76E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.86|P-value:2.52E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.12|P-value:2.11E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:6.29|P-value:8.19E-9 ID:SGTC_908|Compound:3448-7491|FD-Score:6.85|P-value:3.84E-10 ID:SGTC_967|Compound:1306-0166|FD-Score:3.45|P-value:9.33E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.18|P-value:1.03E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:5.48|P-value:4.17E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:-5.31|P-value:1.15E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.55|P-value:8.01E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.95|P-value:5.34E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.78|P-value:1.07E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:3.62E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.93|P-value:2.00E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:2.34E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.02|P-value:3.17E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.46|P-value:4.74E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.82|P-value:7.36E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.63|P-value:5.42E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.68|P-value:5.33E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.57|P-value:7.59E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.70|P-value:1.20E-5 ID:SGTC_1615|Compound:st002656|FD-Score:4.10|P-value:1.14E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.49|P-value:8.35E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.48|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.46|P-value:9.11E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.19|P-value:1.56E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-4.67|P-value:1.67E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.98|P-value:3.88E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.59|P-value:7.08E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:2.25E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.67|P-value:4.69E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.48|P-value:8.66E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.80|P-value:3.14E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.91|P-value:2.14E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.54|P-value:2.25E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.76|P-value:4.22E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.53|P-value:8.60E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-6.05|P-value:3.60E-8 ID:SGTC_2379|Compound:9035213|FD-Score:-4.73|P-value:1.30E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-4.12|P-value:1.27E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.58|P-value:2.33E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.71|P-value:1.44E-7 ID:SGTC_2472|Compound:5377652|FD-Score:3.68|P-value:4.62E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.92|P-value:2.48E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.02|P-value:1.77E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.82|P-value:6.31E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:-6.23|P-value:1.43E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.87|P-value:2.96E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.87|P-value:7.41E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-7.84|P-value:1.42E-12 ID:SGTC_3018|Compound:9082602|FD-Score:4.53|P-value:2.31E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-3.68|P-value:5.48E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.78|P-value:3.35E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.69|P-value:4.50E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.75|P-value:4.37E-4

Top fitness defect scores for YOL095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.10 5.3 µM 7.10E-42 101 1.12E-51
2 SGTC_173 1273-0061 11.20 2.7 µM 4.01E-24 mitochondrial stress 32 1.49E-29
3 SGTC_310 1273-0058 8.14 1.1 µM 1.43E-13 mitochondrial stress 84 2.00E-16
4 SGTC_275 trichlorophene 8.09 5.7 µM 2.01E-13 mitochondrial stress 73 3.05E-16
5 SGTC_10 0279-0212 7.28 42.6 µM 3.20E-11 TRP & mitochondrial translation 11 1.66E-13
6 SGTC_908 3448-7491 6.85 47.7 µM 3.84E-10 mitochondrial stress 30 3.60E-12
7 SGTC_161 4065-0411 6.37 162.2 µM 5.37E-9 23 9.48E-11
8 SGTC_876 0720-0963 6.29 56.8 µM 8.19E-9 2 1.60E-10
9 SGTC_63 0099-0242 6.20 26.7 µM 1.28E-8 mitochondrial stress 25 2.79E-10
10 SGTC_2454 5-benzylidenerhodanine 5.71 10.4 µM 1.44E-7 TRP & mitochondrial translation 14 5.57E-9
11 SGTC_988 1497-1057 5.48 103.0 µM 4.17E-7 1 2.08E-8
12 SGTC_1319 1306-0155 5.46 43.7 µM 4.74E-7 4 2.43E-8
13 SGTC_820 1582-0060 5.46 59.9 µM 4.76E-7 9 2.44E-8
14 SGTC_119 0121-0043 5.25 24.8 µM 1.21E-6 mitochondrial stress 47 7.72E-8
15 SGTC_1627 st003713 5.19 25.6 µM 1.56E-6 calcium & mitochondrial duress 39 1.06E-7
16 SGTC_832 4083-0019 5.12 164.0 µM 2.11E-6 translation 34 1.54E-7
17 SGTC_1318 1280-3875 5.02 124.0 µM 3.17E-6 9 2.54E-7
18 SGTC_1742 st038235 4.98 28.9 µM 3.88E-6 mitochondrial stress 76 3.26E-7
19 SGTC_1373 2887-0003 4.82 58.5 µM 7.36E-6 Golgi 8 7.19E-7
20 SGTC_1597 7-benzyloxygramine 4.70 47.5 µM 1.20E-5 calcium & mitochondrial duress 77 1.31E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.525 3.05E-236 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.478 7.53E-191 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.450 2.41E-167 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.450 2.17E-166 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.449 2.27E-166 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.444 6.09E-162 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.441 1.33E-159 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.440 7.72E-159 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.439 2.70E-158 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.439 8.53E-158 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.438 2.43E-157 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.434 1.43E-154 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.433 2.84E-153 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.432 1.96E-152 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.425 2.19E-147 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C